Search results for "THERAPY"

Purification of Nano-Porous Silicon for Biomedical Applications

2011

Recently, various bio-medical applications of nanoporous silicon (np-Si) have been suggested. This work investigates the biocompatibility of np-Si particles taking into account hazardous residua confined in the pores after preparation. The emphasis is on the potential application of such particles as oxygen photosensitizer for photodynamic therapy of cancer, which requires both negligible toxicity of np-Si particles in darkness and a high photo-cyto-toxic effect due to generation of singlet oxygen under illumination. Considerable amounts of water soluble toxic impurities are found to be present in the nanoporous shell of micrometer-sized np-Si particles immediately after their preparation b…

Conjugation strategies of insulin to nanogels: new hope for nanogels Alzheimer's disease therapy?

2014

Effect of composition of Solid Lipid Nanoparticles on their chemical-physical properties and potential for gene therapy

2015

Affective Arousal During Blaming in Couple Therapy: Combining Analyses of Verbal Discourse and Physiological Responses in Two Case Studies

2016

Blaming one’s partner is common in couple therapy and such moral comment often evokes affective arousal. How people attune to each other as whole embodied beings is a current focus of interest in psychotherapy research. This study contributes to the literature by looking at attunement during critical moments in therapy interaction. Responses to blaming in verbal dialogue and at the level of the autonomic nervous system (ANS) were investigated in two couple therapy cases with a client couple and two therapists. Video-recorded couple therapy sessions were analyzed using discursive psychology and a narrative approach. The use of positioning, a discourse analytic tool, was also studied. ANS res…

Gendered positioning: Addressing gendered power and cultural discourses in therapeutic conversations

2016

This research examined gendered positioning in therapeutic conversations, especially in treatment of intimate partner violence (IPV). A feminist-informed reading combined with a discursive psychological approach was applied in three studies on positioning in therapeutic conversations. This reading focused on gendered positioning, gendered power and cultural discourses. Thus, the aim of this research was to examine how gender is constructed in therapeutic conversations that deal with couple relationship issues, and how the power distribution this entails is addressed in these conversations. The data consisted of videotaped and transcribed couple therapy sessions and group treatment sessions …

Medicinal and aromatic plants in agricultural research, when considering criteria of multifunctionality and sustainability

2022

Over the last twenty years, agriculture has witnessed significant changes in terms of energy requirements, advanced technologies and practices. This is in response to the impacts of crop production on the climate and environment and increasing awareness of the importance of agricultural sustainability through organic farming. Agriculture encompasses complex production systems and certain aspects of multifunctionality and sustainability have become fundamental for these systems. Agricultural activity can provide various functions in agro-ecosystems, such as producing food, managing natural resources, and conserving landscape and plant biodiversity; contributing to the cultural, historical an…

Targeting GSK3 and Associated Signaling Pathways Involved in Cancer

2020

Glycogen synthase kinase 3 (GSK-3) is a serine/threonine (S/T) protein kinase. Although GSK-3 originally was identified to have functions in regulation of glycogen synthase, it was subsequently determined to have roles in multiple normal biochemical processes as well as various disease conditions. GSK-3 is sometimes referred to as a moonlighting protein due to the multiple substrates and processes which it controls. Frequently, when GSK-3 phosphorylates proteins, they are targeted for degradation. GSK-3 is often considered a component of the PI3K/PTEN/AKT/GSK-3/mTORC1 pathway as GSK-3 is frequently phosphorylated by AKT which regulates its inactivation. AKT is often active in human cancer a…

Neck–Shoulder Region Training for Chronic Headache in Women: A Randomized Controlled Trial

2023

Objectives We investigated whether a specific exercise program for the neck–shoulder region reduces headache intensity, frequency, and duration, and how it influences neck disability among women with chronic headache compared to a control group. Design Two-center randomized controlled trial. Subjects 116 working-age women. Intervention The exercise group (n = 57) performed a home-based program with six progressive exercise modules, over 6 months. The control group (n = 59) underwent six placebo-dosed transcutaneous electrical nerve stimulation sessions. Both groups performed stretching exercises. Main measures The primary outcome was pain intensity of headache, assessed using the Numeric Pa…

Strength training in treatment of chronic neck pain

2022

Background: Chronic non-specific neck pain is common in modern industrialized countries causing suffering, disability and considerable economical losses for individuals and society. Treatment is commonly advice for stretching and strength exercises in primary health care. However, if improvements are not satisfactory, patients may seek specialist care. The purpose of this study was to evaluate the effectiveness of multimodal rehabilitation in treatment of chronic neck pain. Methods: The study group comprised of 56 patients with chronic neck pain, who participated rehabilitation for three weeks and one-week follow-up period after eight months at an inpatient rehabilitation facility. The aim …

Mechanisms of cell death in canine parvovirus-infected cells provide intuitive insights to developing nanotools for medicine

2010

Jonna Nykky, Jenni E Tuusa, Sanna Kirjavainen, Matti Vuento, Leona GilbertNanoscience Center and Department of Biological and Environmental Science, University of Jyväskylä, FinlandAbstract: Viruses have great potential as nanotools in medicine for gene transfer, targeted gene delivery, and oncolytic cancer virotherapy. Here we have studied cell death mechanisms of canine parvovirus (CPV) to increase the knowledge on the CPV life cycle in order to facilitate the development of better parvovirus vectors. Morphological studies of CPV-infected Norden laboratory feline kidney (NLFK) cells and canine fibroma cells (A72) displayed characteristic apoptotic events. Apoptosis was f…