Search results for "THERAPY"
showing 10 items of 12482 documents
Endovascular Treatment for Chronic Cerebrospinal Venous Insufficiency in Patients with Multiple Sclerosis
2012
Objective. The aim of this study was to evaluate the impact of endovascular treatment for chronic cerebrospinal venous insufficiency on chronic fatigue in multiple sclerosis patients. Methods. Severity of fatigue was measured with Fatigue Severity Scale (FSS) in 340 patients before the treatment and after 6-month follow-up. Results. We found statistically significant improvement of fatigue. After the treatment, mean FSS score dropped from 4.7 to 3.8. However, these post-procedural changes were not evenly distributed. While the patients with no fatigue (FSS<2.0) or mild/moderate fatigue (FSS 2.0-3.9) did not report significantly changed fatigue, the patients with severe fatigue (FSS≥4.0) exp…
Targeting the tumor mutanome for personalized vaccination therapy
2012
Next generation sequencing enables identification of immunogenic tumor mutations targetable by individualized vaccines. In the B16F10 melanoma system as pre-clinical proof-of-concept model, we found a total of 563 non-synonymous expressed somatic mutations. Of the mutations we tested, one third were immunogenic. Immunization conferred in vivo tumor control, qualifying mutated epitopes as source for effective vaccines.
Interactive multiobjective optimization for finding the most preferred exercise therapy modality in knee osteoarthritis
2022
Abstract Background There are no explicit guidelines or tools available to support clinicians in selecting exercise therapy modalities according to the characteristics of individual patients despite the apparent need. Objective This study develops a methodology based on a novel multiobjective optimization model and examines its feasibility as a decision support tool to support healthcare professionals in comparing different modalities and identifying the most preferred one based on a patient’s needs. Methods Thirty-one exercise therapy modalities were considered from 21 randomized controlled trials. A novel interactive multiobjective optimization model was designed to characterize the effic…
Kuntoutuminen lonkan tekonivelleikkauksesta : kuntoutujien kertomat tarinamallit
2012
TIIVISTELMÄ Kuntoutuminen lonkan tekonivelleikkauksesta – kuntoutujien kertomat tarinamallit Knaapi-Junnila Sari Fysioterapian pro gradu-tutkielma. Jyväskylän yliopisto, liikunta- ja terveystieteiden tiedekunta, terveystieteiden laitos, 2012. 167 sivua, 36 liitesivua. Tämä tutkimus on osa Jyväskylän yliopiston johtamaa Osallistava potilasohjaus fysioterapiassa -tutkimushanketta. Tämän osatutkimuksen tavoitteena on ymmärtää kuntoutumisen merkityksiä lonkan tekonivelleikkauksesta kuntoutuville. Tutkimusaineisto koostuu kymmenen, 63–79-vuotiaan kuntoutujan haastatteluista leikkaukseen valmistautuessa ja siitä kuntoutumisen alkuvaiheessa. Tutkimuksessa selvitetään, minkälaisia tarinoita he kert…
Person reference as a device for constructing experiences as typical in group therapy.
2008
Sharing one's experiences is a crucial activity in group therapies. In such therapies, groups can be either constituted around one problem or goal common to all the clients, or the group can work as a place in which clients can learn from one another and share experiences whether their individual problems are similar or not. Almost all (psycho) therapy types have a group application, and groups are assumed to be rather efficient in psychological progressing (see, e.g. Corey, 1986; Wootton, 1977). In this article I will concentrate on one type of group therapy, namely the Minnesota model group therapy for addicts, and examine how the clients share experiences and, especially, how they constr…
Efficacy of one-year maintenance in early adjuvant chemotherapy for intermediate risk non-muscle-invasive bladder cancer. Preliminary results of a ra…
2008
Introduction and Objective: The clinical value of early intravesical adjuvant chemotherapy after TUR of intermediate risk non-muscle-invasive bladder cancer (NMI TCCB) is well established. On the other hand, the optimal schedule regimen and the role of maintenance are still debated. The aim of the present study was to evaluate the effectiveness of one-year maintenance schedule in patients submitted to TUR plus adjuvant early intravesical chemotherapy. Methods: Between May 2002 and August 2003, 577 patients, were recruited. All patients underwent TUR and early (within 6 hours) intravesical chemotherapy with epirubicin at the dose of 80 mg diluted in 60 ml of saline solution. When histology w…
Rhabdomyosarcoma of the head and neck in pediatric patients: a systematic review.
2022
Rhabdomyosarcoma (RMS) is a soft tissue malignant tumor of mesenchymal cell origin, which usually shows variable differentiation of muscle cells. It is the most common solid sarcoma in children. The most usual site of occurrence are the head and neck regions. RMS presents a variety of histologic features, and so differential diagnosis with other small round cell tumors is needed. Hence, it has been very useful to the field to undertake additional immunohistochemical studies to determine the diagnosis and, on occasions, to assign subtype tumors. A systematic review of three databases (Medline, Biological Science Collection and Health & Medical Collection) was carried out with the purpose of …
Antitumor Cell-Complex Vaccines Employing Genetically Modified Tumor Cells and Fibroblasts
2014
The present study evaluates the immune response mediated by vaccination with cell complexes composed of irradiated B16 tumor cells and mouse fibroblasts genetically modified to produce GM-CSF. The animals were vaccinated with free B16 cells or cell complexes. We employed two gene plasmid constructions: one high producer (pMok) and a low producer (p2F). Tumor transplant was performed by injection of B16 tumor cells. Plasma levels of total IgG and its subtypes were measured by ELISA. Tumor volumes were measured and survival curves were obtained. The study resulted in a cell complex vaccine able to stimulate the immune system to produce specific anti-tumor membrane proteins (TMP) IgG. In the g…
Recuperación muscular mediante la técnica fisioterápica del rodillo de espuma (foam roller)
2020
El músculo esa una estructura presente en la mayoría de animales que permite el movimiento. El daño muscular se solventa mediante la instauración de procesos de regeneración que se demoran en base al tipo de daño y la extensión del mismo. Existen múltiples estrategias para atajar el daño muscular pero el comportamiento a nivel metabólico de algunas de ellas no ha sido descrito. La hipótesis es que algunos de estas estrategias, concretamente en relación a la herramienta Foam Roller, o rodillo de espuma, podrían tener un efecto protector hacia el daño muscular. El Foam Roller, pues, podría atenuar el daño muscular y la inflamación acelerando los procesos curativos propios al organismo. La not…
A four-session acceptance and commitment therapy based intervention for depressive symptoms delivered by masters degree level psychology students: a …
2013
Background:Depressive symptoms are one of the main reasons for seeking psychological help. Shorter interventions using briefly trained therapists could offer a solution to the ever-rising need for early and easily applicable psychological treatments.Aims:The current study examines the effectiveness of a four-session Acceptance and Commitment Therapy (ACT) based treatment for self-reported depressive symptoms administered by Masters level psychology students.Method:This paper reports the effectiveness of a brief intervention compared to a waiting list control (WLC) group. Participants were randomized into two groups: ACT (n= 28) and waiting list (n= 29). Long-term effects were examined using…