Search results for "THERAPY"
showing 10 items of 12482 documents
The relationship between skin conductance and eye contact of spouses in couple therapy
2017
Katsekontaktin ja ihon sähkönjohtavuuden välistä yhteyttä on tutkittu aiemminkin, mutta tutkimusta ei ole tehty monitoimijaisessa terapiatilanteessa. Tämän tutkimuksen tarkoituksena oli tarkastella ihon sähkönjohtavuuden ja katsekontaktin välistä yhteyttä pariterapiassa pariskunnan välisen synkronian kautta, ja lisäksi selvittää, kuinka ihon sähkönjohtavuus muuttuu katsekontaktin eri hetkinä: ennen kuin katsekontakti alkaa, sen alkamishetkellä, ja alkamishetken jälkeen. Oletuksena oli, että ihon sähkönjohtavuuden vasteet nousevat katsekontaktin alkuhetkellä. Lisäksi tarkasteltiin, onko miehillä ja naisilla eroa ihon sähkönjohtavuuden vasteissa. Tutkimuksen otos koostui 11 pariskunnasta, joi…
Exergaming in the treatment of gait, balance, and quality of life in Parkinson's disease: Overview of systematic reviews
2023
Introduction: Postural instability and gait impairments are common in people with PD, both of which have a negative effect on their quality of life. Systematic reviews have demonstrated benefits of using exergaming in enhancing these outcomes. However, there is no consensus over whether exergaming therapy is better than conventional physical therapy for enhancing gait, balance, and quality of life. Objectives: The aim of this overview is to systematically synthesize and evaluate the available evidence found in published systematic reviews and meta-analyses, on the effects of exergaming therapy on balance, gait, and quality of life, compared to conventional physical therapy or no interventio…
Assessment of sleep disturbances with the athlete sleep screening questionnaire in Chinese athletes.
2021
This study investigated the factors that are associated with sleep disturbances among Chinese athletes. Sleep quality and associated factors were assessed by the Athlete Sleep Screening Questionnaire (ASSQ, n = 394, aged 18–32 years, 47.6% female). Sleep difficulty score (SDS) and level of sleep problem (none, mild, moderate, or severe) were used to classify participants' sleep quality. Categorical variables were analyzed by Chi-square or fisher's exact tests. An ordinal logistic regression analysis was used to explore factors with poor sleep (SDS ≥8). Approximately 14.2% of participants had moderate to severe sleep problem (SDS ≥8). Fifty-nine percent of the athletes reported sleep distu…
Rac1-Regulated Endothelial Radiation Response Stimulates Extravasation and Metastasis That Can Be Blocked by HMG-CoA Reductase Inhibitors
2011
Radiotherapy (RT) plays a key role in cancer treatment. Although the benefit of ionizing radiation (IR) is well established, some findings raise the possibility that irradiation of the primary tumor not only triggers a killing response but also increases the metastatic potential of surviving tumor cells. Here we addressed the question of whether irradiation of normal cells outside of the primary tumor augments metastasis by stimulating the extravasation of circulating tumor cells. We show that IR exposure of human endothelial cells (EC), tumor cells (TC) or both increases TC-EC adhesion in vitro. IR-stimulated TC-EC adhesion was blocked by the HMG-CoA reductase inhibitor lovastatin. Glycyrr…
THERP and HEART integrated methodology for human error assessment
2014
Medical errors are one of the leading causes of death and injury in radiation therapy administration as reported in the literature. This point out an overall deficiency in management allowing patient treatment in the absence of suitable quality assurance processes. Clinical records of major accidental exposure events in radiotherapy show that there is a combination of factors contributing to the accident such as deficient staff training, lack of independent checks, lack of quality control procedures, and absence of overall supervision. Another finding is that training generally addresses only normal situations and does not prepare radiotherapy staff for unusual situations, resulting in a la…
High-Gradient RF laboratory at IFIC for medical applications
2018
General interest has been shown over the last years for compact and more affordable facilities for hadron-therapy. The High-Gradient (HG) know-how and technology for normal-conducting accelerating RF (Radio-Frequency) electron linac (linear accelerator) structures recently developed for projects such as CLIC (CERN), has raised the achievable accelerating gradient from 20-30 MV/m up to 100-120 MV/m. This gain has come through a better understanding of the high-power RF vacuum arcs or breakdowns (BD) phenomena, the development of quantitative HG RF design methods and refinements in fabrication techniques. This can allow for more compact linacs also for protons, which is potentially important …
Radiolabeling of Nanoparticles and Polymers for PET Imaging
2014
Nanomedicine has become an emerging field in imaging and therapy of malignancies. Nanodimensional drug delivery systems have already been used in the clinic, as carriers for sensitive chemotherapeutics or highly toxic substances. In addition, those nanodimensional structures are further able to carry and deliver radionuclides. In the development process, non-invasive imaging by means of positron emission tomography (PET) represents an ideal tool for investigations of pharmacological profiles and to find the optimal nanodimensional architecture of the aimed-at drug delivery system. Furthermore, in a personalized therapy approach, molecular imaging modalities are essential for patient screeni…
Value of Combined PET Imaging with [18F]FDG and [68Ga]Ga-PSMA-11 in mCRPC Patients with Worsening Disease during [177Lu]Lu-PSMA-617 RLT
2021
Despite the promising results of prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) in metastatic castration-resistant prostate cancer (mCRPC), some patients show worsening disease during PSMA-RLT. We investigated the value of combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging in this setting. In n = 29 mCRPC patients with worsening disease after a median of four cycles of [177Lu]Lu-PSMA-617 RLT, combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging was performed to detect [18F]FDG-avid lesions with low or no PSMA expression (mismatch lesions). To evaluate prognostic implication of mismatch, survival analyses regarding presence, location, and [18F]FDG PET-derived para…
Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experi…
2022
HCV elimination; Mental health disorders; Sofosbuvir/velpatasvir Eliminación del VHC; Trastornos de salud mental; Sofosbuvir/velpatasvir Eliminació del VHC; Trastorns de salut mental; Sofosbuvir/velpatasvir Hepatitis C virus (HCV) is prevalent in people with mental health disorders, a priority population to diagnose and cure in order to achieve HCV elimination. This integrated analysis pooled data from 20 cohorts in seven countries to evaluate the real-world effectiveness of the pangenotypic direct-acting antiviral (DAA) sofosbuvir/velpatasvir (SOF/VEL) in people with mental health disorders. HCV-infected patients diagnosed with mental health disorders who were treated with SOF/VEL for 12 w…
Acute and chronic effects of cold treatment on physiological variables and neuromuscular function during a short training period in men
2015
Introduction. Recovery following various physical exercises is a complicated process. The exercise session can involve strong demands on both muscle structure and energy production (aerobic and anaerobic). Many exercise sessions also induce muscle damage (exercise induced muscle damage; EIMD). Different recovery methods attempt to alleviate or prevent EIMD and its associated symptoms, such as muscle soreness and swelling, and reduction in muscle function. One of the used strategies is cold treatment (cryotherapy), which decreases tissue temperature and subsequently effects on e.g. blood flow, metabolism and neural conductance velocity. To date, there is conflicting evidence to support the u…