Search results for "THIQ"
showing 10 items of 285 documents
Functional Evaluation of THIQ, a Melanocortin 4 Receptor Agonist, in Models of Food Intake and Inflammation
2007
The central melanocortinergic system plays an important role in regulating different aspects of energy homeostasis and the immunomodulatory response. In the present study, we evaluated the in vivo activities of food intake suppression and anti-inflammatory activity of THIQ, which has been proposed to possess high and selective melanocortin-4 receptor agonistic activity in vitro. The results showed that THIQ (0.1, 0.3 and 1 nmol/rat, intracerebroventricularly) is less effective in reducing food intake and body weights of rats than the non-selective melanocortin receptor agonist melanotan II. Electron paramagnetic resonance measurements in mice brain tissue showed that THIQ at doses of 0.001 …
Compte rendu de : Agnieszka Soltysik Monnet. The Poetics and Politics of the American Gothic : Gender and Slavery in Nineteenth-Century American Lite…
2012
Depuis une bonne vingtaine d’années, les études sur le gothique dans la littérature américaine foisonnent, transformant un genre jusque-là parfois marginalisé dans les universités en un champ de recherche important. Avec The Poetics and Politics of the American Gothic?: Gender and Slavery in Nineteenth-Century American Literature, Agnieszka Soltysik Monnet, professeur à l’Université de Lausanne, apporte une contribution innovante à ce domaine.
Analyse de l’évolution des formes de l’habitat dans la Plaine de Troyes du 5e millénaire à la fin de l’âge du Bronze
2015
International audience
The beaker phenomenon and the Genomic transformations of Northwest Europe
2018
Bell Beaker pottery spread across western and central Europe beginning around 2750 BCE before disappearing between 2200–1800 BCE. The mechanism of its expansion is a topic of long-standing debate, with support for both cultural diffusion and human migration. We present new genome-wide ancient DNA data from 170 Neolithic, Copper Age and Bronze Age Europeans, including 100 Beaker-associated individuals. In contrast to the Corded Ware Complex, which has previously been identified as arriving in central Europe following migration from the east, we observe limited genetic affinity between Iberian and central European Beaker Complex-associated individuals, and thus exclude migration as a signific…
Interpreting the Beaker phenomenon in Mediterranean France: an Iron Age analogy
2012
http://antiquity.ac.uk/ant/086/ant0860131.htm; International audience; The author offers a new descriptive explanation of the Beaker phenomenon, by focusing on Mediterranean France and making reference to the Greek influx in the same area 2000 years later. In the Iron Age, the influence began with an exploratory phase, and then went on to create new settlements and colonise new areas away from the coast. The Beaker analogy is striking, with phases of exploration and implantation and acculturation, but adjusted to include a final phase where Beaker practice was more independent. Comparing the numerous models put forward to explain it, the author shows that immigration and a cultural package …
Production, gestion et utilisation des outillages lithiques du Chasséen méridional
2006
Is the opposition between specialized and non specialized productions a key to characterizethe lithic assemblages from the southern Chassey Culture ? The former have been used to define the culture itself and to build up theories based on craft specialization to approach the social organization of these Neolithic groups. Our first studies about the latter show that they reveal specific technical activities conducted at the site or that they are useful to build up interpretation on both site functions and social organization.We base our study on a corpus of sites localized in the south of France–from Alpes-Maritimes to Lot–between 4300 and 353500 BC cal. Different site function are here repr…
Dopaminergic isoquinolines with hexahydrocyclopenta[ ij ]-isoquinolines as D 2 -like selective ligands
2016
Dopamine receptors (DR) ligands are potential drug candidates for treating neurological disorders including schizophrenia or Parkinson's disease. Three series of isoquinolines: (E)-1-styryl-1,2,3,4-tetrahydroisoquinolines (series 1), 7-phenyl-1,2,3,7,8,8a-hexahydrocyclopenta[ij]-IQs (HCPIQs) (series 2) and (E)-1-(prop-1-en-1-yl)-1,2,3,4- tetrahydroisoquinolines (series 3), were prepared to determine their affinity for both D1and D2-like DR. The effect of different substituents on the nitrogen atom (methyl or allyl), the dioxygenated function (methoxyl or catechol), the substituent at the β-position of the THIQ skeleton, and the presence or absence of the cyclopentane motif, were studied. We…
Jean Roberti (Baumeister des 15. Jh.)
2012
Archéologie du cheval
2002
Ouvrage de vulgarisation; Les restes d'équidés découverts sur les sites archéologiques constituent la source documentaire la plus cohérente que l'on puisse imaginer pour écrire l'histoire du cheval et de ses rapports avec l'homme, sur une période qui couvre sept millénaires, du Mésolithique aux temps modernes.Cette présentation repose essentiellement sur les découvertes archéologiques réalisées en France, mais certaines approches synthétiques prennent en compte un domaine plus large, celui de l'Europe. De même, si l'accent est mis sur l'apport des ossements découverts en fouille, d'autres sources, iconographiques ou textuelles notamment, sont sollicitées ici et là. Nous n'avons pas les moye…
Une histoire de l'élevage : les animaux et l'Archéologie
1987
Ouvrage de vulgarisation