Search results for "TIMIT"
showing 10 items of 150 documents
Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives
2011
Microtubules are dynamic structures that play a crucial role in cellular division and are recognized as an important target for cancer therapy. In search of new compounds with strong antiproliferative activity and simple molecular structure, a new series of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-(hetero)aryl ethynyl thiophene derivatives was prepared by the Sonogashira coupling reaction of the corresponding 5-bromothiophenes with several (hetero)aryl acetylenes. When these compounds were analyzed in vitro for their inhibition of cell proliferation, the 2- and 3-thiophenyl acetylene derivatives were the most powerful compounds, both of which exerted cytostatic effects at submicromolar conc…
L'estructura sil·làbica del dialecte valencià
1997
Aquest treball se centra a descriure l'estructura sil·làbica del valencià en el marc de la teoria de l'optimitat. En concret, s'analitzen els mecanismes que determinen la sil·labificació de les consonants com a obertures o com a codes. També s'estudia en quines circumstàncies les consonants poden aparéixer com a codes i obertures complexes. Pel que respecta a les vocals, es descriuen els principis que determinen la incorporació d'aquests segments als nuclis i als marges sil·labics. Finalment, l'últim capítol de la tesi es dedica a analitzar com el sistema de principis de la llengua s'encarrega de seleccionar la forma òptima dels pronoms febles en cada entorn.
La Sindicatura de Comptes de la Comunitat Valenciana: la legitimación a través de la modernización administrativa
2022
Este trabajo tiene como objetivo fundamental analizar las estrategias legitimadoras de cambio de una institución político-administrativa en su etapa de madurez. En concreto, este estudio de caso se centra en la Sindicatura de Comptes de la Comunitat Valenciana, órgano de fiscalización regional que se dedica, principalmente, a la rendición de cuentas y al control de legalidad económico-financiero. Para ello, partiremos de la teoría del ciclo de vida de la organización (Levitt, 1965) como marco teórico y plantearemos la hipótesis de que todas las instituciones necesitan legitimidad para mantenerse en el campo en el que ejercen sus competencias. Entre los resultados de este estudio destacan la…
Novel insights on [1,2]oxazolo[5,4‐e]isoindoles on multidrug resistant acute myeloid leukemia cell line
2022
A series of [1,2]oxazolo[5,4‐e]isoindole derivatives was evaluated against HL‐60 cell line and its multidrug resistance (MDR) variant, HL‐60R, resistant to doxorubicin and to other P‐gp substrates by overexpressing the efflux pump. They displayed antiproliferative activities, with IC50 values ranging from 0.02 to 5.5μM. In particular, the newly synthesized compound 4k produced synergistic effects in terms of cell growth inhibition and cell death induction either in combination with a Vinca alkaloid, Vinblastine, and a Taxane, Paclitaxel in HL‐60R cells. The study of the mechanism of action indicated that all compounds showed antimitotic activity through inhibition of tubulin polymerization.…
In favour of layered feet: A response to Golston
2021
In this response we argue that the factorial typology predicted in Martínez-Paricio & Kager (2015), which representationally relies on the existence of internally layered ternary feet, is complete and accurate. We demonstrate it does not suffer from the problematic cases of overgeneration pointed out by Golston (this issue). Additionally, we corroborate the idea that the internally layered ternary foot is a metrical representation that is typologically warranted for stress phenomena as well as for segmental and tonal metrically conditioned distributions. We suggest that Golston's claim that "no stress system requires internally layered ternary feet" appears to be too strong and is not empir…
That German Stuff : Negotiating linguistic legitimacy in a foreign language classroom
2018
This qualitative case study of one German suburban high school classroom in the Midwestern United States examines how learners of German negotiate their linguistic legitimacy, which is defined as discursively constructed acceptance or validation for their language use. Specifically, it investigates how the students negotiated legitimacy for using their target language German in their classroom. Based on the premise that linguistic legitimacy is crucial for the maintenance and development of speakers’ languages, data was collected and analyzed from classroom recordings, semi-structured interviews, and participant observations. Findings revealed that, while English dominated the lessons as th…
Ecrire à un média-radio en 2000 / en 2011 : élaboration de l’intime par l’écrit en langue non maternelle ou déplacement ?
2011
National audience
Usefulness of antimitochondrial antibody 113-1 in diagnosis and classification of salivary gland tumours with oncocytic differentiation
2010
Abstract Introduction and objectives Salivary gland tumours usually show great variability both in their morphopathology as well as their clinical behaviour. In the present study, the usefulness of antimitochondrial monoclonal antibody 113-1 in the diagnosis and categorization of salivary tumours was studied. Material and methods A series of 22 benign and malignant salivary tumours and 5 non-tumoral salivary gland specimens were immunohistochemically analysed using an antimitochondrial monoclonal antibody (Ab Mo 113-1), which recognises a non-glycosylated mitochondrial protein of 60 Kd. Results The use of this antibody allowed us to recognize all salivary tumours with oncocytic differentiat…
Le dernier baiser de Roméo et Julette : comment mettre en scène l'intime?
2019
International audience
Synthesis, cytotoxicity, and inhibitory effects on tubulin polymerization of a new 3-heterocyclo substituted 2-styrylquinazolinones
2004
In order to study the influence of 3-substitution on the cytotoxic activity of 2-styrylquinazolinones, new 6-chloro-2-styryl-3-(heteroaryl)-4(3H)-quinazolinones were synthesized by refluxing equimolar amounts of 6-chloro-2-methyl-3-(heteroaryl)-4(3H)-quinazolinones and benzaldehyde in glacial acetic acid. At 1 microg ml(-1) concentration, almost all 2-styrylquinazolinones showed some cytotoxic activity against the L1210 and K562 leukemia cell lines. However, only 6-chloro-2-styryl-3-(pyrimidin-2yl)-4(3H)-quinazolinone inhibited the growth of these cells by over 50%. This last compound was also the only member of the series that inhibited tubulin polymerization, with an IC(50) value of 5.8 v…