Search results for "TISSUE"
showing 10 items of 4413 documents
Topological canal foliations
2019
Regular canal surfaces of $\mathbb{R}^3$ or $\mathbb{S}^3$ admit foliations by circles: the characteristic circles of the envelope. In order to build a foliation of $\mathbb{S}^3$ with leaves being canal surfaces, one has to relax the condition “canal” a little (“weak canal condition”) in order to accept isolated umbilics. Here, we define a topological condition which generalizes this “weak canal” condition imposed on leaves, and classify the foliations of compact orientable 3-manifolds we can obtain this way.
Repeated kidney re-transplantation—the Eurotransplant experience: a retrospective multicenter outcome analysis
2020
Transplant international (2020). doi:10.1111/tri.13569
Intérêts et limites de l’electrostimulation pour l’évaluation, le traitement et la prévention des altérations neuromusculaires induites par l’exercic…
2004
L'objectif de ce travail était d'une part d'étudier les altérations neuromusculaires induites par un exercice excentrique sollicitant les muscles extenseurs du genou, et d'autre part d'étudier l'efficacité de l'électrostimulation (ES) comme moyen d'évaluation, de traitement et de prévention de ces altérations. La première étude de ce travail consistait à évaluer les contributions des mécanismes centraux et périphériques à la diminution de la contraction maximale volontaire observée après l'exercice excentrique. La fatigue basse fréquence (FBF) et la fatigue centrale expliquaient principalement la diminution du moment maximal volontaire après l'exercice excentrique. Le but de la deuxième étu…
Overcoming resistance to HER2 blockade in breast cancer: AXL as a promising druggable target and prognostic biomarker
2022
Introduction: Breast cancer is a heterogeneous disease consisting of uncontrolled growth of epithelial cells originating in the ducts or breast lobules. It is currently the most diagnosed cancer worldwide and the fifth cause of cancer-related death in general population, but the first cause in women. Breast cancer incidence is higher in developed countries due to increased risk factors and to increased and earlier detection by mammography screening, which considerably reduces mortality. This is the reason why transitioning countries have higher mortality despite having lower incidence. Regarding the origin of the disease, it is evidenced that the pathways implicated in normal development of…
Qualiment: the scientifist expertise to promote innovation in food companies
2011
Tkanka tłuszczowa – budowa i funkcje, ze szczególnym uwzględnieniem charakterystyki wybranych adipokin i ich wpływu na organizm
2019
Wprowadzenie i cel pracy. Światowa epidemia otyłości przyczyniła się do rozwoju badań mających na celu dokładne poznanie budowy i zrozumienie procesów zachodzących w tkance tłuszczowej, której nadmiar jest głównym wyznacznikiem tej choroby. Obecnie wiadomo, że tkanka tłuszczowa dzięki wytwarzanym adipokinom może być jedną z przyczyn zaburzeń związanych z otyłością. Celem pracy jest przedstawienie budowy i funkcji tkanki tłuszczowej, ze szczególnym uwzględnieniem jej aktywności hormonalnej. Skrócony opis stanu wiedzy. Adipokiny wytwarzane przez tkankę tłuszczową działają nie tylko lokalnie (autokrynnie i parakrynnie), ale także na narządy odległe (działanie endokrynne). Regulują one metaboli…
Etanercept maintains the clinical benefit achieved by infliximab in patients with rheumatoid arthritis who discontinued infliximab because of side ef…
2007
Objective: To evaluate the efficacy of switching to etanercept treatment in patients with rheumatoid arthritis who already responded to infliximab, but presented side effects. Methods: Charts of 553 patients with rheumatoid arthritis were retrospectively reviewed to select patients who responded to the treatment with infliximab and switched to etanercept because of occurrence of adverse effects. Clinical data were gathered during 24 weeks of etanercept treatment and for the same period of infliximab treatment before infliximab was stopped. Disease Activity Score computed on 44 joints (DAS-44), erythrocyte sedimentation rate (ESR) 1st hour, Visual Analogue Scale (VAS) of pain, Health Assessm…
Abemaciclib: safety and effectiveness of a unique cyclin-dependent kinase inhibitor
2020
Introduction: The discovery and the clinical availability of novel cyclin-dependent kinases 4 and 6 inhibitors have profoundly changed the therapeutic scenario of metastatic hormone receptor-positive breast carcinoma. Among these inhibitors, abemaciclib can induce potent and sustained cell cycle arrest and immune system stimulation. Areas covered: This review summarizes the safety profile and clinical efficacy data on abemaciclib alone or in combination with aromatase inhibitors or fulvestrant in metastatic hormone receptor-positive breast carcinoma. The management of patients treated with abemaciclib is the object of this paper. Expert opinion: As shown in phase 2 and 3 clinical trials on …
Can the odours modulate salivation? Impact of the nature of the odorant
2015
Introduction :Saliva plays numerous roles in the oral cavity, especially in digestion and taste perception. It is well admitted that tastants are effective stimuli of salivation and that the salivary response (flow and composition) depends on the nature of the tastant. However, the impact of odours on salivation is poorly known and not consensual. Odours are the first chemical signal informing about food palatability before ingestion. In this context, it is necessary to understand if the salivary secretions are modulated in function of this sensory signal. The aim of this study is to compare the salivary flow response after stimulation by different odours having different hedonic values.Mat…
SARS-COV-2 PANDEMIC IN THE MEDITERRANEAN AREA: EPIDEMIOLOGY AND PERSPECTIVES
2020
In December 2019, a disease caused by a novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was identified in Wuhan, Hubei Province, China. In March 2020, the World Health Organization declared the pandemic due to SARS-CoV-2. At the end of May 2020, SARS-CoV-2 confirmed cases and deaths due to novel Coronavirus disease (COVID-19) were about 6.5 million and 380,000, worldwide. In this commentary the authors argue on the impact of SARS-CoV-2 pandemic in different epidemiological settings within the Mediterranean area, discussing any possible association with higher or lower virus spread according to climatic factors, pollutants, characteristics of general population, and organi…