Search results for "TLE"

The use of steel angles for the connection of laminated glass beams: Experiments and modelling

2012

Abstract In the present paper the experimental results relative to three-point bending tests on multilayer glass beams and on semi-rigid connections realised with stainless double web angles are presented and discussed. Small and medium size glass beams were tested and load–deflection curves and crack patterns at failure were recorded. The laminated glass specimens, of equal cross-section, were characterised by three different combinations of annealed float and fully thermally tempered glass plies and different interlayers. Steel joints constituted by double web angles to connect two glass beams were tested adopting several geometrical configurations and using stainless steel bolts preloade…

Fracture stratigraphy and oil first migration in Triassic shales, Favignana Island, western Sicily, Italy

2021

This study aims at evaluating the control exerted by fracture stratigraphy and diagenetic processes on oil first migration through an outcropping, mixed carbonate-siliciclastic succession. The present work included results of sedimentological, paleontological, mineralogical, petrographic, structural, and microstructural analyses carried out on organic-rich shales exposed at the Favignana Island of Sicily, Italy. The analyses focus on Upper Triassic yellowish siltstones and greyish laminated dolomitic limestones, which form a 10's of m-thick succession exposed along the westernmost portion of the Sicilian fold-and-thrust belt. The studied succession deposited in a coastal lagoon associated t…

Fabric control on strain and rupture of heterogeneous shale samples by using a non-conventional mechanical test

2004

Abstract This work was a part of the preliminary stage of the ANDRA project on a deep-seated research laboratory for the feasibility study of long-term radioactive waste storage in the Callovo–Oxfordian argillites of the Eastern part of the Paris Basin. These rocks are bedded, their density is about 2.4, and they contain an average of 30% carbonates and 25% quartz. Thick (5 mm) sections from cores were put through a non-conventional device called CGI testcell (CGI: Centre de Geologie de l'Ingenieur, i.e. Engineering Geology Centre). The aim of this versatile device is to achieve plane deformation tests under compressive uniaxial loading together with controlled temperature and humidity cond…

Ontology and semantics: an Aristotelian inspiration,

2013

Final Results of a Phase I/II Trial of the Combination Bendamustine and Rituximab With Temsirolimus (BeRT) in Relapsed Mantle Cell Lymphoma and Folli…

2020

Abstract. In this phase I/II study, we explored the combination of Temsirolimus with Bendamustine and Rituximab (BeRT) in patients with relapsed or refractory (r/r) follicular lymphoma (FL) or mantle cell lymphoma (MCL). Patients with 1 to 3 previous therapies received Bendamustine (90 mg/m2, day 1 + 2) and Rituximab (375 mg/m2, day 1) with Temsirolimus in doses from 25 to 75 mg in phase I and 50 mg Temsirolimus in phase II, added on day 1, 8, 15 of a 28 days cycle. The primary endpoint of the phase II was ORR at the end of treatment. Overall, 39 (29 MCL, 10 FL) patients were included. Median age was 71 years and median pretreatment number was 2. Grade 3/4 non-hematologic adverse events wer…

Conversioni nel Vicino Oriente Ottomano e diffusione del cattolicesimo a Betlemme

2009

L'articolo analizza la diffusione del Cattolicesimo nel villaggio di Betlemme durante il XII secolo

Trauma and storytelling in Betty Louise Bell’s Faces in the Moon

2018

The dominant understanding of trauma as an epistemological crisis that can be mimetically passed on to readers has in the twenty-first century been criticized for its apolitical and ahistorical ori...

Verso una dimensione narrativa delle mappe

2021

Tra il pensiero e la costruzione dell’architettura il disegno ha un ruolo baricentrico per connettere i diversi protagonisti di una realizzazione e per coinvolgere la collettività facendo percepire inedite prospettive. La scrittura si rivela utile per esplicitare ciò che nella grafica è sotteso e per stabilire un ordine nuovo nel ragionamento progettuale. I rapporti fra segni e significati si moltiplicano nei sistemi informativi recenti in cui si ha la sensazione di poter dire moltissimo (dati numerici e spaziali) ma a volte sfugge quella sintesi indispensabile per una interpretazione concreta, finalizzata alla costruzione di possibili esperienze fisiche. Per l’esplorazione dell’uso di dive…

Isolation of the Endothelin B Receptor from Bovine Lung Structure, Signal Sequence, and Binding Site

1995

Bovine lung endothelin-B receptor has been isolated in good yield with a new procedure involving the use of endothelin-1 coupled to iminobiotin with a long spacer and avidin-agarose affinity chromatography. Contrary to previous reports, evidence has been obtained that the native form of this receptor corresponds to the full-length transcript expected on the basis of cDNA clones. The binding of endothelin to a variety of shortened fragments of the full receptor suggests that the long N-terminal sequence of this receptor has very little influence on the binding of endothelin and that the main determinants of the endothelin binding site might be constituted by residues in the sixth, and possib…

New evidence for the multiplicity of ubiquinone- and inhibitor-binding sites in the mitochondrial complex I.

2000

Determination of the number of ubiquinone- and inhibitor-binding sites in the mitochondrial complex I (NADH:ubiquinone oxidoreductase) is a controversial question with a direct implication for elaborating a suitable model to explain the bioenergetic mechanism of this complicated enzyme. We have used combinations of both selective inhibitors and common ubiquinone-like substrates to demonstrate the multiplicity of the reaction centers in the complex I in contrast with competition studies that have suggested the existence of a unique binding site for ubiquinone. Our results provide new evidence for the existence of at least two freely exchangeable ubiquinone-binding sites with different specif…