Search results for "TLE"

MODULATION OF BLADDER α1-ADRENERGIC RECEPTOR SUBTYPE EXPRESSION BY BLADDER OUTLET OBSTRUCTION

2002

Purpose: α1-Adrenergic receptor (α1AR) antagonists are effective for relieving obstructive and irritative symptoms in patients with bladder outlet obstruction. While the α1aAR is responsible for prostate smooth muscle relaxation and outlet obstruction relief, to our knowledge the mechanisms underlying the relief of irritative symptoms remain to be determined. Therefore, we investigated mechanisms by which bladder α1AR subtypes may be involved in this process.Materials and Methods: We studied 42 rats, including 6 unoperated controls, 17 sham operated controls and 19 obstructed animals. Animals were characterized for baseline voiding pattern, followed by surgical intervention or sham surgery …

Gozos a nuestra Señora de Belen, Patrona de la Villa de Almanssa.

El full orlat. Grav. xil. enmarcat de la Mare de Déu, flanquejat per gerros amb flors. Text del goig a tres col. separades per filets.

Gozos a N. Señora de Belen, venerada en la Parroquial Iglesia de Mislata

El full orlat Grav. xil. enmarcat de la Mare de Déu, flanquejat per figures d'angels Text del goig a tres col. separades per filets

Between Atoms and Humours. Lucretius' Didactic Poetry as a Model of Integrated and Bifocal Physiology

2012

Lucretius has often been regarded as one of the fathers of modern science, and also in recent years several studies have explored his influence far beyond a merely literary perspective. In this paper I analyse specifically the importance of the poet's 'eclectic' attitude in physiology from the point of view of his 'Fortleben' in early modern thought. I suggest that the typical eclectic combination of physics and biology, atomism and macroscopy, which the 'De rerum natura' shows in its didactic structure both through its images and even more through its conscious scientific reflection, built an attractive basis for attempts in the modern period at harmonising corpuscularian theories and qual…

Expression of P, S, and F1C adhesins by cytotoxic necrotizing factor1-producing Escherichia coli from septicemic and diarrheic pigs

1997

Nineteen papC-positive cytotoxic necrotizing factor 1 (CNF1)-producing Escherichia coli isolates from pigs with septicemia or diarrhea were tested for the presence of pap-, sfa-, and afa-related sequences encoding P/Prs, S/F1C, and Dr/AFA adhesins respectively. Production of adhesins by isolates was tested by mannose-resistant hemagglutination (MRHA), sialidase treatment of erythrocytes and particle agglutination tests. Production of P, S, and F1C fimbriae by isolates was also examined by immunofluorescence. All isolates were pap+ by PCR. Eighteen isolates (95%) were MRHA for ovine and human A erythrocytes and exhibited GalNac-GalNac receptor specificity associated with class III P(Prs) adh…

The pyrrole moiety as a template for COX-1/COX-2 inhibitors

2000

Aroyl- and thiophene-substituted pyrrole derivatives have been synthesized as a new class of COX-1/COX-2 inhibitors. The inhibition of COX-1 was evaluated in a biological system using bovine PMNLs as the enzyme source, whereas LPS-stimulated human monocytes served as the enzyme source for inducible COX-2. The determination of the concentration of arachidonic acid metabolites was performed by HPLC for COX-1 and RIA for COX-2. Variation of the substitution pattern led to a series of active compounds which showed inhibition for COX-1 and COX-2. Structural requirements for the development of COX-1/COX-2 inhibitors are discussed.

Mechanical Behavior of Steel Fiber-Reinforced Concrete Beams Bonded with External Carbon Fiber Sheets

2017

This study investigates the mechanical behavior of steel fiber-reinforced concrete (SFRC) beams internally reinforced with steel bars and externally bonded with carbon fiber-reinforced polymer (CFRP) sheets fixed by adhesive and hybrid jointing techniques. In particular, attention is paid to the load resistance and failure modes of composite beams. The steel fibers were used to avoiding the rip-off failure of the concrete cover. The CFRP sheets were fixed to the concrete surface by epoxy adhesive as well as combined with various configurations of small-diameter steel pins for mechanical fastening to form a hybrid connection. Such hybrid jointing techniques were found to be particularly adva…

Damage and plasticity at the interfaces in composite materials and structures

2009

Abstract The structural behavior at the interface between two surfaces of ductile, brittle or quasi-brittle materials is studied by a new analytical elastoplastic damaging model. The model is developed in the framework of a thermodynamically consistent theory. The Helmholtz free energy is written to predict the materials’ hardening or softening. An isotropic damage is considered and the possible effects of dilatancy are taken into account including non-associative flow rules. The interface laws are presented both in a rate and a discrete incremental form. The analytical formulation is then implemented into a finite element code and two structural members are studied to validate the model. T…

Le associazioni e le società sportive dilettantistiche alla luce della normativa di fonte statale e federale: verifica della compatibilità con il det…

Il lavoro si pone lo scopo di analizzare nello specifico la tematica dei soggetti collettivi dilettantistici analizzando per iniziare la normativa che li concerne e valutando specificamente anche alcuni profili controversi che li riguardano, quali: a) la questione della rappresentanza apparente; b) il danno all'immagine dell’ente. In seguito ci si soffermerà sulle conseguenze funzionali del riconoscimento dell’autonomia dello sport e in particolare si analizzerà la natura aperta della sua struttura. Infatti, lo sport esercitato collettivamente a livello dilettantistico non tollera ingerenze statali per il tramite di controlli, autorizzazioni, registri e albi volti a creare differenziazioni …

NP-completeness of the hamming salesman problem

1985

It is shown that the traveling salesman problem, where cities are bit strings with Hamming distances, is NP-complete.