Search results for "TLE"
showing 10 items of 2417 documents
Assessing the carbon footprint across the supply chain: Cow milk vs soy drink
2022
Abstract Since livestock product consumption could have a significant effect on tackling climate change, in the few last years, there has been an increasing consumer demand for non-dairy alternatives. Despite plant-based beverages being considered crucial to foster the transition towards sustainable diet models, no studies have yet compared the level of emissions of plant-based beverages with animal-based ones. The present study aims at computing the carbon footprint of cow milk and that of soy drink and evaluating the carbon footprint results in the light of the substitutability of cow's milk with soy drink, analyzing the potential environmental, economic and nutritional trade-offs between…
Roles for ELMOD2 and Rootletin in ciliogenesis.
2021
AbstractELMOD2 is a GTPase activating protein (GAP) with uniquely broad specificity for ARF family GTPases. We previously showed that it acts with ARL2 in mitochondrial fusion and microtubule stability and with ARF6 during cytokinesis. Mouse embryonic fibroblasts deleted for ELMOD2 also displayed changes in cilia related processes including increased ciliation, multiciliation, ciliary morphology, ciliary signaling, centrin accumulation inside cilia, and loss of rootlets at centrosomes with loss of centrosome cohesion. Increasing ARL2 activity or overexpressing Rootletin reversed these defects, revealing close functional links between the three proteins. This was further supported by the fin…
Constraining lithospheric flow.
2016
The motion of Earth's tectonic plates—the lithosphere—is driven by the subduction of relatively cold and dense oceanic plates into the mantle. The resulting forces drive the motions of continental plates, but the manner in which this happens depends on the effective viscosities of the lithosphere and mantle. On page 1515 of this issue, Liu and Hasterok ( 1 ) discuss a novel method of constraining viscosities of the lithosphere from geophysical data.
Endothelin receptor B in trabecular meshwork
2007
Abstract Endothelin-1 (ET-1), the most potent vasoconstrictor known to date, seems to be involved in the pathogenesis of primary open angle glaucoma. ET-1 was found in different tissues of the eye and in high concentrations in the aqueous humour. The effects of ET-1 are mediated by two receptors, ET-A receptor (ET-AR) and ET-B receptor (ET-BR), which are both expressed in bovine trabecular meshwork (TM). ET-1 induced contraction of TM predominantly by activation of ET-AR. This study analyzes the role of ET-BR in TM function and investigates the synthesis of ET-1 by human TM (HTM) cells. The effect of IRL-1620, a specific ET-BR agonist, on contractility of bovine TM (BTM) was investigated wi…
Accesibilidad y provisión de servicios de interés general en las áreas rurales de la Unión Europea: un análisis a partir del Eurobarómetro
2014
La finalidad de este trabajo es ofrecer un estado de la cuestión sobre el acceso y provisión de Servicios de Interés General (SeIG) en las áreas rurales de la Unión Europea. Se identifican fuerzas de cambio, oportunidades y dificultades relativas a los SeIG que pueden contribuir a impulsar o ralentizar los procesos de desarrollo rural. Se lleva a cabo una revisión de las principales aproximaciones teóricas y se presentan diversos análisis empíricos a partir de los escasos datos homogéneos disponibles. A partir del conocimiento adquirido se formula un conjunto de reflexiones sobre la función de los SeIG en los procesos de cambio rural en la UE.
Bartlett formalism generating functions and Z-transforms in fluctuation and noise theory
1983
Abstract “La theorie des fonctions generatrices s'adapte elle meme et avec la plus grande generalite aux questions des probabilite les plus difficiles.” (Laplace, 1812) “An important part of probability theory consists of the derivation of the probability distribution of the sum of n random variables, each of which obeys a given probability law, and the development of asymptotic forms of these distributions valid for increasing n. Probability generating functions owe their dominant position to the simplification they permit to both problems. Their employment to obtain the successive moments of a probability distribution and to solve the difference equations of probability theory is ancillar…
Statistical physics: Some basic principles of fluctuation and noise theory
1983
Abstract Models have traditionally played a significant role in statistical mechanics. In view of the complexity of the system which statistical mechanics attempt to describe, this is not at all surprising. The study of simplified models has frequently revealed the underlying mathematical structure of many physical questions and in so doing the study of models has contributed directly to a clarification of several paradoxes which beset statistical mechanics. In this paper some of the models which appear to be useful for the discussion of non-equilibrium phenomena are examined in some detail. As usual these models are extremely simplified versions of the actual situations. It is, finally, as…
Lo verosímil en la ética de Aristóteles: una aporía en el vocabulario filosófico griego
2007
While the mainstream of modern moral philosophy has always assumed that the characteristic situation in moral judgments should be the certitude, Aristotle’s moral philosophy is dominated by the idea of verisimilitude. As a matter of fact, its main concept, namely «virtue», is doubly permeated by this idea, both in its psychological and epistemological sides: we cannot know with certitude (only with verisimilitude) what is entailed by the adscription of a virtue (e.g. generosity), both generally and in a particular case. Nevertheless, verisimilitude is a good enough ground for action.<br><br>Mientras que la corriente principal de la filosofía moral moderna da por supuesto que la …
Glycosylation deficiency at either one of the two glycan attachment sites of cellular prion protein preserves susceptibility to bovine spongiform enc…
2004
The conversion into abnormally folded prion protein (PrP) plays a key role in prion diseases. PrP(C) carries two N-linked glycan chains at amino acid residues 180 and 196 (mouse). Previous in vitro data indicated that the conversion process may not require glycosylation of PrP. However, it is conceivable that these glycans function as intermolecular binding sites during the de novo infection of cells on susceptible organisms and/or play a role for the interaction of both PrP isoforms. Such receptor-like properties could contribute to the formation of specific prion strains. However, in earlier studies, mutations at the glycosylation sites of PrP led to intracellular trafficking abnormalitie…
A glimpse of gluons through deeply virtual compton scattering on the proton
2017
The internal structure of nucleons (protons and neutrons) remains one of the greatest outstanding problems in modern nuclear physics. By scattering high-energy electrons off a proton we are able to resolve its fundamental constituents and probe their momenta and positions. Here we investigate the dynamics of quarks and gluons inside nucleons using deeply virtual Compton scattering (DVCS)—a highly virtual photon scatters off the proton, which subsequently radiates a photon. DVCS interferes with the Bethe-Heitler (BH) process, where the photon is emitted by the electron rather than the proton. We report herein the full determination of the BH-DVCS interference by exploiting the distinct energ…