Search results for "TMA"
showing 10 items of 336 documents
Zum Akademiestreit als eine Stufe auf dem Weg des Künstlers in sich selbst. Carl Hauptmanns "Einhart der Lächler"
2016
W powieści „Einhart der Lächler“ Carl Hauptmann opisuje drogę życiową artysty, która okazuje się poszukiwaniem własnej tożsamości. Carl Hauptmann ubiera swą opowieść w popularną formę powieści edukacyjnej. Droga Einharta prowadzi przez instytucje sztuki, wówczas napiętnowane przez konflikt pomiędzy wykształceniem akademickim artysty a jego kreatywną wolnością. Poniższy tekst koncentruje się na osadzeniu tego napięcia w ramach historycznych. W dalszej części przedstawione zostaną powiązania głównego bohatera z zaprzyjaźnionym z Carlem Hauptmannem malarzem – Otto Muellerem.
Cuticular hydrocarbon profiles differ between ant body parts: implications for communication and our understanding of CHC diffusion.
2020
Abstract Insect cuticular hydrocarbons (CHCs) serve as communication signals and protect against desiccation. They form complex blends of up to 150 different compounds. Due to differences in molecular packing, CHC classes differ in melting point. Communication is especially important in social insects like ants, which use CHCs to communicate within the colony and to recognize nestmates. Nestmate recognition models often assume a homogenous colony odor, where CHCs are collected, mixed, and redistributed in the postpharyngeal gland (PPG). Via diffusion, recognition cues should evenly spread over the body surface. Hence, CHC composition should be similar across body parts and in the PPG. To te…
Somatic copy number alterations are associated with EGFR amplification and shortened survival in patients with primary glioblastoma.
2019
Glioblastoma (GBM) is the most common malignant primary tumor of the central nervous system. With no effective therapy, the prognosis for patients is terrible poor. It is highly heterogeneous and EGFR amplification is its most frequent molecular alteration. In this light, we aimed to examine the genetic heterogeneity of GBM and to correlate it with the clinical characteristics of the patients. For that purpose, we analyzed the status of EGFR and the somatic copy number alterations (CNAs) of a set of tumor suppressor genes and oncogenes. Thus, we found GBMs with high level of EGFR amplification, low level and with no EGFR amplification. Highly amplified tumors showed histological features of…
Estrogen Receptor Signaling and the PI3K/Akt Pathway Are Involved in Betulinic Acid-Induced eNOS Activation
2016
Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid with anti-inflammatory, antiviral and anti-cancer properties. Beneficial cardiovascular effects such as increased nitric oxide (NO) production through enhancement of endothelial NO synthase (eNOS) activity and upregulation of eNOS expression have been demonstrated for this compound. In the present study, immortalized human EA.hy 926 endothelial cells were incubated for up to 1 h with 1–100 µM BA and with the phosphatidylinositol-3-kinase (PI3K) inhibitors LY294002 and wortmannin, or the estrogen receptor (ER) antagonist ICI 182,780. Phosphorylation status of eNOS and total eNOS protein were analyzed by Western blotting us…
Enrichment of Bacterioplankton Able to Utilize One-Carbon and Methylated Compounds in the Coastal Pacific Ocean
2018
International audience; Understanding the temporal variations and succession of bacterial communities involved in the turnover of one-carbon and methylated compounds is necessary to better predict bacterial impacts on the marine carbon cycle and air-sea carbon fluxes. The ability of the local bacterioplankton community to exploit one-carbon and methylated compounds as main source of bioavailable carbon during a productive and less productive period was assessed through enrichment experiments. Surface seawater was amended with methanol and trimethylamine-N-oxide (TMAO), and bacterial abundance, production, oxygen consumption, as well as methanol turnover and growth rates of putative methylot…
Thermostabilization of BSA in TMAO Water Mixtures by Infrared Spectroscopy
2019
Background:Trimethylamine-N-Oxide (TMAO) is a small organic molecule derived from the metabolism of L-carnitine and choline after ingestion of animal food. TMAO has many functions such as electron acceptor, an osmolyte, stabilizer of macromolecules folding. It seems that TMAO plays an important role in nature but, in humans, it is a remnant of the evolution of the osmolyte system.Objective:The present paper is addressed on the study of thermal stability of hydrated Bovine Serum Albumins (BSA) in the presence of water and TMAO water solution by means of InfraRed spectroscopy. In particular, this work has investigated the protein amide I spectral regions, which is sensitive to protein seconda…
Drone arc routing problems
2018
[EN] In this article, we present some drone arc routing problems (Drone ARPs) and study their relation with well-known postman ARPs. Applications for Drone ARPs include traffic monitoring by flying over roadways, infrastructure inspection such as by flying along power transmission lines, pipelines or fences, and surveillance along linear features such as coastlines or territorial borders. Unlike the postmen in traditional ARPs, drones can travel directly between any two points in the plane without following the edges of the network. As a consequence, a drone route may service only part of an edge, with multiple routes being used to cover the entire edge. Thus the Drone ARPs are continuous o…
A New Branch-and-Cut Algorithm for the Generalized Directed Rural Postman Problem
2016
The generalized directed rural postman problem, also known as the close-enough arc routing problem, is an arc routing problem with some interesting real-life applications, such as routing for meter reading. In this article we introduce two new formulations for this problem as well as various families of new valid inequalities that are used to design and implement a branch-and-cut algorithm. The computational results obtained on test bed instances from the literature show that this algorithm outperforms the existing exact methods
The Chinese Postman Problem with Load-Dependent Costs
2018
[EN] We introduce an interesting variant of the well-known Chinese postman problem (CPP). While in the CPP the cost of traversing an edge is a constant (equal to its length), in the variant we present here the cost of traversing an edge depends on its length and on the weight of the vehicle at the moment it is traversed. This problem is inspired by the perspective of minimizing pollution in transportation, since the amount of pollution emitted by a vehicle not only depends on the travel distance but also on its load, among other factors. We define the problem, study its computational complexity, provide two mathematical programming formulations, and propose two metaheuristics for its soluti…
The directed profitable rural postman problem with incompatibility constraints
2017
[EN] In this paper, we study a variant of the directed rural postman problem (RPP) where profits are asso- ciated with arcs to be served, and incompatibility constraints may exist between nodes and profitable arcs leaving them. If convenient, some of the incompatibilities can be removed provided that penalties are paid. The problem looks for a tour starting and ending at the depot that maximizes the difference between collected profits and total cost as sum of traveling costs and paid penalties, while satisfying remaining incompatibilities. The problem finds application in the domain of road transportation service, and in particular in the context of horizontal collaboration among carriers …