Search results for "TNRC6C-AS1"

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Long Non-coding Antisense RNA TNRC6C-AS1 Is Activated in Papillary Thyroid Cancer and Promotes Cancer Progression by Suppressing TNRC6C Expression

2018

Context: Evidences have shown the important role of long non-coding antisense RNAs in regulating its cognate sense gene in cancer biology. Objective: Investigate the regulatory role of a long non-coding antisense RNA TNRC6C-AS1 on its sense partner TNRC6C, and their effects on the aggressiveness and iodine-uptake ability of papillary thyroid cancer (PTC). Design: TNRC6C-AS1 was identified as the target long non-coding RNA in PTC by using microarray analysis and computational analysis. In vitro gain/loss-of-function experiments were performed to investigate the effects of TNRC6C-AS1 and TNRC6C on proliferation, apoptosis, migration, invasion and iodine-uptake ability of TPC1 cells. Expressio…

0301 basic medicinelong non-coding antisense RNAendocrine system diseasesEndocrinology Diabetes and MetabolismTNRC6C-AS1lcsh:Diseases of the endocrine glands. Clinical endocrinologyPapillary thyroid cancer03 medical and health sciencesEndocrinology0302 clinical medicineDownregulation and upregulationSense (molecular biology)medicinepapillary thyroid cancerTNRC6COriginal Researchiodine accumulationGene knockdownMessenger RNAlcsh:RC648-665ChemistryMicroarray analysis techniquesRNAmedicine.diseaseAntisense RNA030104 developmental biology030220 oncology & carcinogenesisCancer researchFrontiers in Endocrinology

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