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Les tours dits de la chair dans les autofictions de Philippe Vilain
2016
Le autofinzioni di Philippe Vilain si distinguono per una meticolosa ricerca stilistica e una pratica di riscrittura supposta mettere a nudo la pelle dello scrittore. La scrittura della carne è particolarmente influenzata da tale ricerca: ciò che la sostiene non è tanto ciò cui lo specchio scritturale ci rimanda, bensì ciò che è nascosto nell'implicito dei ricordi in cui i pezzi del godimento si embricano in pezzi di linguaggio. Questo articolo si propone di analizzare la posta in gioco della scrittura autofinzionale di Philippe Vilain nei suoi principali romanzi attraverso la topologia psicoanalitica di Lacan. Philippe Vilain's autofictions are distinguished by a meticulous stylistic resea…
Geometric rough paths on infinite dimensional spaces
2022
Similar to ordinary differential equations, rough paths and rough differential equations can be formulated in a Banach space setting. For $\alpha\in (1/3,1/2)$, we give criteria for when we can approximate Banach space-valued weakly geometric $\alpha$-rough paths by signatures of curves of bounded variation, given some tuning of the H\"older parameter. We show that these criteria are satisfied for weakly geometric rough paths on Hilbert spaces. As an application, we obtain Wong-Zakai type result for function space valued martingales using the notion of (unbounded) rough drivers.
Decay of48-50Ar isotopes
2011
International audience; Information on β-decay properties of neutron-rich 84-05Ar was obtained at the ISOLDE mass-separator facility at CERN using isobaric selectivity. This was achieved by a combination of a plasma-ion source with a cooled transfer line and subsequent mass-separation. Normally, argon beams cannot be mass-separated from intense multi-charged symmetric fission krypton and xenon. Several techniques were used successfully in order to overcome this problem. Implication of the obtained information for a better understanding of the origin of the 48Ca/46Ca isotopic anomaly discovered in inclusions from the Allende meteorite is discussed.
Spectroscopic studies of neutron-deficient light nuclei: decay properties of 21Mg, 25Si and 26P
2003
Neutron‐deficient nuclei with Tz equals to −3/2 and −2 have been produced at the GANIL/LISE3 facility in fragmentation reactions of a 95 MeV/u 36Ar primary beam in a 12C target. For the first time, β‐delayed proton and β‐γ emission has been simultaneously observed in the decay of 21Mg, 25Si and 26P. The decay scheme of the latter is proposed and the Gamow‐Teller strength distribution in its β decay is compared to shell‐model calculations based on the USD interaction. The B(GT) values derived from the absolute measurement of the β‐branching ratios are in agreement with the quenching factor of about 60% obtained for allowed Gamow‐Teller transitions in this mass region. A precise half‐life of …
Diseño por Topología molecular y ensayos farmacológicos de nuevos inhibidores frente a WNT/β-CATENINA Y PI3K/Akt/mTOR
2015
El cáncer colorrectal y el de próstata causan una elevadísima tasa de muerte a nivel mundial. Por lo que, cualquier estrategia para detener o al menos reducir su desarrollo y progresión sería una importante contribución en la investigación actual. Por todo ello, el objetivo principal de la presente Tesis es la identificación de nuevos agentes quimiopreventivos frente al cáncer, que actúen modulando dos de las vías más implicadas en su desarrollo: PI3K/Akt/mTOR y Wnt/β-catenina. Hoy en día, existen diferentes enfoques para el descubrimiento de nuevos hits and leads, pero esta Tesis se centra en la metodología de la Topología Molecular, que ya ha demostrado su extraordinaria eficacia en este …
Menstrual problems and lifestyle among Spanish university women
2020
Menstrual problems affect many young women worldwide, conditioning both their academic performance and quality of life. This study sought to analyse the prevalence of menstrual problems and their possible relationship with lifestyle among Spanish university women, as part of a research project (UniHcos Project) involving a cohort of 11 Spanish universities with 7208 university students. A descriptive analysis was performed using the bivariate chi-square test and the Student&rsquo
Space-filling vs. Luzin's condition (N)
2013
Let us assume that we are given two metric spaces, where the Hausdorff dimension of the first space is strictly smaller than the one of the second space. Suppose further that the first space has sigma-finite measure with respect to the Hausdorff measure of the corresponding dimension. We show for quite general metric spaces that for any measurable surjection from the first onto the second space, there is a set of measure zero that is mapped to a set of positive measure (both measures are the Hausdorff measures corresponding to the Hausdorff dimension of the first space). We also study more general situations where the measures on the two metric spaces are not necessarily the same and not ne…
SYNTHESIS AND ANTITUMOR ACTIVITY OF 2,5-BIS(3'-INDOLYL)-FURANS AND 3,5-BIS(3'-INDOLIY)-ISOXAZOLES, NORTOPSENTIN ANALOGUES
2010
Abstract A series of novel 2,5-bis(3′-indolyl)furans and 3,5-bis(3′-indolyl)isoxazoles were synthesized as antitumor agents. The antiproliferative activity was evaluated in vitro toward diverse human tumor cell lines. Initially 5 isoxazoles and 3 furan derivatives were tested against a panel of 10 human tumor cell lines and the most active derivatives 3c and 4a were selected to be evaluated in an extended panel of 29 cell lines. By exhibiting mean IC50 values of 17.4 μg/mL (3a) and 20.5 μg/mL (4c), in particular 4c showed a high level of tumor selectivity toward the 29 cell lines.
Dehn surgeries and smooth structures on 3-dimensional transitive Anosov flows.
2020
The present thesis is about Dehn surgeries and smooth structures associated with transitive Anosov flows in dimension three. Anosov flows constitute a very important class of dynamical systems, because of its persistent chaotic behaviour, as well as for its rich interaction with the topology of the ambient space. Even if a lot is known about the dynamical and ergodic properties of these systems, there is not a clear understanding about how to classify its different orbital equivalence classes. Until now, the biggest progress has been done in dimension three, where there is a family of techniques intended for the construction of Anosov flows called surgeries.During the realization of this th…
Development of a simple, biocompatible and cost-effective Inulin-Diethylenetriamine based siRNA delivery system
2015
Small interfering RNAs (siRNAs) have the potential to be of therapeutic value for many human diseases. So far, however, a serious obstacle to their therapeutic use is represented by the absence of appropriate delivery systems able to protect them from degradation and to allow an efficient cellular uptake. In this work we developed a siRNA delivery system based on inulin (Inu), an abundant and natural polysaccharide. Inu was functionalized via the conjugation with diethylenetriamine (DETA) residues to form the complex Inu-DETA. We studied the size, surface charge and the shape of the Inu-DETA/siRNA complexes; additionally, the cytotoxicity, the silencing efficacy and the cell uptake-mechanis…