Search results for "TP"

Echocardiographic and angiographic evaluation of left ventricular function during percutaneous transluminal aortic valvuloplasty.

1992

Transesophageal echocardiography was used to study the effect of the balloon inflation on left ventricular function in 20 patients with critical aortic stenosis undergoing balloon valvuloplasty. Balloon inflation caused an increase of end-diastolic (15% to 34%) and end-systolic (57% to 72%) left ventricular volume. Left ventricular wall stress increased from 30 +/- 10 x 10(3) dyn/cm2 at diastole and 121 +/- 40 x 10(3) dyn/cm2 at systole to 44 +/- 11 x 10(3) dyn/cm2 and 191 +/- 55 x 10(3) dyn/cm2, respectively, when the balloon was inflated (P less than 0.05). Turbulent regurgitant jet across the mitral valve increased from 15 +/- 2% to 25 +/- 3% during balloon inflation (P less than 0.01). …

Uztvertais sociālais atbalsts, apmierinātība ar partnerattiecībām un depresijas simptomi sievietēm 4 – 6 nedēļas pēc dzemdībām

2017

Pētījuma jautājumi, kuriem vēlos noskaidrot atbildes pētījumā rezultātā ir, kāda saistība pastāv starp uztverto sociālo atbalstu, apmierinātību ar partnerattiecībām un depresijas simptomiem sievietēm 4 – 6 nedēļas pēc dzemdībām. Otrs pētījuma jautājums ir noskaidrot, kā apmierinātība ar partnerattiecībām un uztvertais sociālais atbalsts prognozē depresijas simptomus sievietēm 4 – 6 nedēļas pēc dzemdībām. Pētījumā piedalījās 31 sieviete, kura bija 4 – 6 nedēļas pēc dzemdībām. Svarīgi nosacījumi bija, lai sievietei būtu piedzimis pirmais bērniņš un lai viņš būtu vesels, kas tika novērtēts pēc Apgares jaundzimušā veselības stāvokļa. Pētījumā tika izmantoti trīs pētījuma instrumenti. Lai noskai…

Controlling protein interactions in blood for effective liver immunosuppressive therapy by silica nanocapsules

2020

Immunosuppression with glucocorticoids is a common treatment for autoimmune liver diseases and after liver transplant, which is however associated with severe side-effects. Targeted delivery of glucocorticoids to inflammatory cells, e.g. liver macrophages and Kupffer cells, is a promising approach for minimizing side effects. Herein, we prepare core–shell silica nanocapsules (SiO2 NCs) via a sol–gel process confined in nanodroplets for targeted delivery of dexamethasone (DXM) for liver immunosuppressive therapy. DXM with concentrations up to 100 mg mL−1 in olive oil are encapsulated while encapsulation efficiency remains over 95% after 15 days. Internalization of NCs by non-parenchymal muri…

ETC-1002: A future option for lipid disorders?

2014

ETC-1002 is a new investigational low density lipoprotein cholesterol (LDL-C)-lowering agent (Esperion Therapeutics, Inc.). ETC-1002 is a dicarboxylic acid derivative with a novel mechanism of action targeting two hepatic enzymes - adenosine triphosphate-citrate lyase (ACL) and adenosine monophosphate-activated protein kinase (AMPK), inhibiting sterol and fatty acid synthesis and promoting mitochondrial long-chain fatty acid oxidation. This agent is currently in phase II clinical research. Available data report that ETC-1002 significantly decreased LDL-C levels (up to 32%) in both patients with normal and elevated baseline levels of triglycerides. Such beneficial effect is superior to curre…

The developers' perspective in Mobile App Markets: an empirical analysis of price drivers

2012

Critical review: Grand challenges in assessing the adverse effects of contaminants of emerging concern on aquatic food webs

2019

Much progress has been made in the past few decades in understanding the sources, transport, fate, and biological effects of contaminants of emerging concern (CECs) in aquatic ecosystems. Despite these advancements, significant obstacles still prevent comprehensive assessments of the environmental risks associated with the presence of CECs. Many of these obstacles center around the extrapolation of effects of single chemicals observed in the laboratory or effects found in individual organisms or species in the field to impacts of multiple stressors on aquatic food webs. In the present review, we identify 5 challenges that must be addressed to promote studies of CECs from singular exposure e…

Morphogenetic (Mucin Expression) as Well as Potential Anti-Corona Viral Activity of the Marine Secondary Metabolite Polyphosphate on A549 Cells

2020

The mucus layer of the nasopharynx and bronchial epithelium has a barrier function against inhaled pathogens such as the coronavirus SARS-CoV-2. We recently found that inorganic polyphosphate (polyP), a physiological, metabolic energy (ATP)-providing polymer released from blood platelets, blocks the binding of the receptor binding domain (RBD) to the cellular ACE2 receptor in vitro. PolyP is a marine natural product and is abundantly present in marine bacteria. Now, we have approached the in vivo situation by studying the effect of polyP on the human alveolar basal epithelial A549 cells in a mucus-like mucin environment. These cells express mucins as well as the ectoenzymes alkaline phospha…

Energetic coupling between plastids and mitochondria drives CO2 assimilation in diatoms.

2015

International audience; Diatoms are one of the most ecologically successful classes of photosynthetic marine eukaryotes in the contemporary oceans. Over the past 30 million years, they have helped to moderate Earth's climate by absorbing carbon dioxide from the atmosphere, sequestering it via the biological carbon pump and ultimately burying organic carbon in the lithosphere. The proportion of planetary primary production by diatoms in the modern oceans is roughly equivalent to that of terrestrial rainforests. In photosynthesis, the efficient conversion of carbon dioxide into organic matter requires a tight control of the ATP/NADPH ratio which, in other photosynthetic organisms, relies prin…

Vis/NIR spectroelectrochemical analysis of poly-(Azure A) on ITO electrode

2006

Electrochromic behavior of poly-(Azure A) on indium–tin oxide electrode is analyzed in an aqueous potassium nitrate solution. The dependence of the absorbance on the applied potential during cyclic voltammograms proves very interesting at two selected characteristic wavelengths: at 925 nm, attributed to an intermediate species and another at 735 nm, attributed to the oxidized form of the polymer. Molar absorptivity coefficients for both species have been calculated from the relationship between current and the derivative of absorbance with respect to time. Voltammograms of formation of the intermediate are simulated from spectroelectrochemical results. Keywords: Poly-(Azure A), Spectroelect…

In situ AFM study of proton-assisted electrochemical oxidation/reduction of microparticles of organic dyes

2008

In situ atomic force microscopy (AFM) images of crystals of organic dyes alizarin, indigo and morin have been monitored during the course of their solid-state electrochemical oxidation/reduction in contact with aqueous acetate buffer. Such images indicate that proton-assisted reduction and oxidation processes are localized in a shallow layer in the vicinity of the particle/electrolyte interface, in agreement with expectances from the Lovric and Scholz model with significantly restricted proton diffusion across the solids. Keywords: Voltammetry of nanoparticles, Atomic force microscopy, Organic dyes, Diffusion