Search results for "TPH2"

showing 3 items of 3 documents

Identification of the cannabinoid receptor type 1 in serotonergic cells of raphe nuclei in mice.

2007

The endocannabinoid system (ECS) possesses neuromodulatory functions by influencing the release of various neurotransmitters, including GABA, noradrenaline, dopamine, glutamate and acetylcholine. Even though there are studies indicating similar interactions between the ECS and the serotonergic system, there are no results showing clear evidence for type 1 cannabinoid receptor (CB1) location on serotonergic neurons. In this study, we show by in situ hybridization that a low but significant fraction of serotonergic neurons in the raphe nuclei of mice contains CB1 mRNA as illustrated by the coexpression with the serotonergic marker gene tryptophane hydroxylase 2, the rate limiting enzyme for t…

Genetic MarkersSerotoninSerotonin uptakeBiologyTryptophan HydroxylaseSerotonergicHippocampuschemistry.chemical_compoundMiceNerve FibersReceptor Cannabinoid CB1Cannabinoid receptor type 1AnimalsRNA MessengerNeurotransmitterIn Situ HybridizationSerotonin Plasma Membrane Transport ProteinsMicroscopy ConfocalTPH2General NeuroscienceAmygdalaEndocannabinoid systemImmunohistochemistryIsoenzymesMice Inbred C57BLnervous systemchemistryDentate GyrusSynapsesRaphe NucleiFemaleSerotoninRaphe nucleiNeuroscienceNeuroscience
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Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): analysis of data from the international multicenter ADHD genetics (IMAGE…

2008

Contains fulltext : 71540.pdf (Publisher’s version ) (Closed access) There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested…

ParentsCandidate geneGenetics and epigenetic pathways of disease [NCMLS 6]2804 Cellular and Molecular NeuroscienceMedizinNeuroinformatics [DCN 3]Linkage Disequilibrium2738 Psychiatry and Mental Health0302 clinical medicineRisk FactorsPerception and Action [DCN 1]Genetics(clinical)Genetics (clinical)0303 health sciencesTPH210058 Department of Child and Adolescent PsychiatryPsychiatry and Mental healthData Interpretation StatisticalFunctional Neurogenomics [DCN 2]Clinical psychologyGenetic Markers2716 Genetics (clinical)Single-nucleotide polymorphism610 Medicine & healthMental health [NCEBP 9]Polymorphism Single NucleotideGenetic determinismGenomic disorders and inherited multi-system disorders [IGMD 3]Molecular epidemiology [NCEBP 1]03 medical and health sciencesCellular and Molecular NeuroscienceCognitive neurosciences [UMCN 3.2]Translational research [ONCOL 3]medicineAttention deficit hyperactivity disorderHumansFamilyGenetic Predisposition to Diseaseddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersAlleleAlleles030304 developmental biologyChi-Square DistributionEndocrinology and reproduction [UMCN 5.2]business.industrymedicine.diseaseGenetic defects of metabolism [UMCN 5.1]Multicenter studyAttention Deficit Disorder with HyperactivityEtiologybusiness030217 neurology & neurosurgeryAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
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Effect of family structure and TPH2 G-703T on the stability of dysregulation profile throughout adolescence

2015

Abstract Background Two different polymorphisms (TPH2 G-703T and 5-HTTLPR) involved in the serotonergic pathway have been reported to play a role, both alone and in interaction with the environment, in early and adult emotion regulation. As most of these studies are cross-sectional, we know little about the impact of these polymorphisms over time, particularly during adolescence. Methods Because we were interested in the effects of these polymorphisms and environment (i.e., family structure) at different time-points on the emotional dysregulation profile, we performed a path analysis model in a general adolescent population sample of a five-year follow-up study. Results We found a high stab…

Settore M-PSI/01 - Psicologia GeneraleMaleAdolescentGenotypeEmotional dysregulationTryptophan Hydroxylase5-HTTLPRSerotonergicDevelopmental psychologyDysregulation profileYoung Adult03 medical and health sciences0302 clinical medicinePolymorphism (computer science)TPH2HumansAffective SymptomsAlleleGene–environment interactionYoung adultAllelesTPH2; 5-HTTLPR; Emotional dysregulation; Adolescence; Family structure; Dysregulation profileSerotonin Plasma Membrane Transport ProteinsPolymorphism GeneticTPH2Emotional dysregulationAdolescence030227 psychiatryPsychiatry and Mental healthClinical Psychology5-HTTLPRFemaleGene-Environment InteractionFamily RelationsPsychologyFamily structure030217 neurology & neurosurgeryFollow-Up StudiesClinical psychologyJournal of Affective Disorders
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