Search results for "TPM1"

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Reconnoitering the Role of Long-Noncoding RNAs in Hypertrophic Cardiomyopathy: A Descriptive Review

2021

Hypertrophic cardiomyopathy (HCM) is the most common form of hereditary cardiomyopathy. It is characterized by an unexplained non-dilated hypertrophy of the left ventricle with a conserved or elevated ejection fraction. It is a genetically heterogeneous disease largely caused by variants of genes encoding for cardiac sarcomere proteins, including MYH7, MYBPC3, ACTC1, TPM1, MYL2, MYL3, TNNI3, and TNNT23. Preclinical evidence indicates that the enhanced calcium sensitivity of the myofilaments plays a key role in the pathophysiology of HCM. Notably, this is not always a direct consequence of sarcomeric variations but may also result from secondary mutation-driven alterations. Long non-coding R…

QH301-705.5CardiomyopathyTPM1ReviewBiologyCatalysisInorganic ChemistrymedicineHumansBiology (General)Physical and Theoretical ChemistryQD1-999Molecular BiologySpectroscopyGeneticslong non-coding RNAgenetic variantsOrganic ChemistryACTC1Hypertrophic cardiomyopathyGeneral MedicineCardiomyopathy Hypertrophichypertrophic cardiomyopathymedicine.diseaseLong non-coding RNAcardiovascular diseasesComputer Science ApplicationsChemistryMYL3Cardiovascular diseases Genetic variants Hypertrophic cardiomyopathy Long non-coding RNA Cardiomyopathy Hypertrophic Humans RNA Long NoncodingMYL2RNA Long NoncodingMYH7International Journal of Molecular Sciences
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