Search results for "TRANSFORMATION"

Generalizations of Clausen's formula and algebraic transformations of Calabi-Yau differential equations

2011

AbstractWe provide certain unusual generalizations of Clausen's and Orr's theorems for solutions of fourth-order and fifth-order generalized hypergeometric equations. As an application, we present several examples of algebraic transformations of Calabi–Yau differential equations.

Kollineationen und Schliessungssätze für Ebene Faserungen

1979

Every affine central collineation of a translation plane π induces a special collineation of the projective space π spanned by the spreadF belonging to π. Here the relations between these special collineations of π and certain incidence propositions inF are investigated; so new proofs are given for some characterisations of (A,B)-regular spreads included in [7].

LORENTZ SPACES OF VECTOR-VALUED MEASURES

2003

Geometry of the projectivization of ideals and applications to problems of birationality

2018

In this thesis, we interpret geometrically the torsion of the symmetric algebra of the ideal sheaf I_Z of a scheme Z defined by n+1 equations in an n-dimensional variety. This is equivalent to study the geometry of the projectivization of I_Z. The applications of this point of view concern, in particular, the topic of birational maps of the projective space of dimension 3 for which we construct explicit birational maps that have the same algebraic degree as their inverse, free and nearly-free curves for which we generalise a characterization of free curves by extending the notion of Milnor and Tjurina numbers. We tackle also the topic of homaloidal hypersurfaces, our original motivation, fo…

An improved algorithm for thermal dynamic simulation of walls using Z-transform coefficients

2003

The Transfer Function Method (TFM), recommended by American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE), is one of the most modern tools available to solve heat transfer problems in building envelopes and environments. TFM utilises Z-transform to solve the equations system that describes the heat transfer in a multi-layered wall. Due to an analogy with an electric circuit, it is possible to write the equations system in a matrix suitable to be solved by computer. Authors carried out an analysis on an historical building placed in the south of Italy to test the reliability and the quality of the thermal dynamic simulation using TFM. The analysis is performed usi…

Field desorption mass spectrometric characterization of thiol conjugates related to the oxidative metabolism of the anticancer drug 4′-(9-acridinylam…

1983

Conjugation products with glutathione (GSH) and other endogenous thiol derivatives related to the oxidative metabolism of the anticancer drug, 4′-(9-acridinlyamino) methanesulfon-m-anisidide (m-AMSA) were synthesized and characterized by field desorption mass spectrometry. The primary microsomal oxidation product of m-AMSA, m-AQDI, was prepared by MnO2 oxidation of the parent drug and reacted with equimolar GSH, cysteine, N-acetylcysteine and N-acetylcysteine methyl ester to form m-AMSA-(5′)-thiol conjugates linkedat the aniline ring, as major products. Field desorption mass spectra of the conjugates provided abundant [MH]plus; ions, and characteristic fragment ions by cleavage at the thioe…

Semi-physiologic model validation and bioequivalence trials simulation to select the best analyte for acetylsalicylic acid

2015

Abstract The objective of this paper is to apply a previously developed semi-physiologic pharmacokinetic model implemented in NONMEM to simulate bioequivalence trials (BE) of acetyl salicylic acid (ASA) in order to validate the model performance against ASA human experimental data. ASA is a drug with first-pass hepatic and intestinal metabolism following Michaelis–Menten kinetics that leads to the formation of two main metabolites in two generations (first and second generation metabolites). The first aim was to adapt the semi-physiological model for ASA in NOMMEN using ASA pharmacokinetic parameters from literature, showing its sequential metabolism. The second aim was to validate this mod…

Computer simulations for bioequivalence trials: Selection of analyte in BCS class II and IV drugs with first-pass metabolism, two metabolic pathways …

2018

A semi-physiological two compartment pharmacokinetic model with two active metabolites (primary (PM) and secondary metabolites (SM)) with saturable and non-saturable pre-systemic efflux transporter, intestinal and hepatic metabolism has been developed. The aim of this work is to explore in several scenarios which analyte (parent drug or any of the metabolites) is the most sensitive to changes in drug product performance (i.e. differences in in vivo dissolution) and to make recommendations based on the simulations outcome. A total of 128 scenarios (2 Biopharmaceutics Classification System (BCS) drug types, 2 levels of KM Pgp, in 4 metabolic scenarios at 2 dose levels in 4 quality levels of t…

An Application of Analytic Network Process in the Planning Process: The Case of an Urban Transformation in Palermo (Italy)

2014

The primary objective of this study is to test the multicriteria analysis application in favor of a selection process among alternative transformations of an urban area in the city of Palermo. The choice is referred to as a strategyoriented one aiming to create “new urban centralities” able to redraw all urban structures that start to activate renewal processes within the existing city. The application of multicriteria analysis technique, such as the Analytic Network Process (ANP) - BOCR model, is due to the need to represent the complexity of the decision problem characterized by interrelations among several elements described by many indicators from different levels. The case study is als…

A Paradigm Interpreting the City and the Analytic Network Process for the Management of Urban Transformations

2018

When urban and environmental transformations occur in areas where the equilibrium between nature and culture is complex and fragile, public ad-ministrations could decide to induce private investments using several tools, such as financial contributions to those projects of refurbishment that better re-spect the purpose of improving the environmental quality and of preserving the local architecture. Multicriteria models may support public decision process re-garding this issue, but it is essential to adopt a scientific paradigm that provides a major theoretical reference. This study proposes the development of a net-work model based on the scientific paradigm by Rizzo and the Analytic Net-wo…