Search results for "TRANSFORMATION"
showing 10 items of 1634 documents
Grass Pea
2011
Grass pea (Lathyrus. sativus L.) is an annual legume crop with high protein content and remarkable resistance to extreme environmental conditions, including fl ooding, drought, salinity and low soil fertility, and a signifi cant degree of resistance to biotic stress agents. It is rightly considered one of the most promising sources of calories and protein for the vast and expanding populations of drought-prone and marginal areas of Asia and Africa and as an interesting alternative for cropping systems diversifi cation in marginal lands in Europe, Australia and America. It is a dual purpose crop with great agronomic potential as a grain and forage legume. Nevertheless, as a result of the lit…
Rho GTPases are over-expressed in human tumors.
1999
Small GTPases of the Rho family are involved in the regulation of a variety of cellular processes, such as the organization of the microfilamental network, cell-cell contact and malignant transformation. To address the question of whether Rho proteins are involved in carcinogenesis in man, we compared their expression in tumors from colon, breast and lung with that of the corresponding normal tissue originating from the same patient. As shown by Rho-specific 32P-ADP-ribosylation, as well as Western-blot analysis, the amount of RhoA protein was largely increased in all 3 types of tumors tested. The most dramatic differences in the expression of Rho GTPases were observed in breast tissue. All…
Rho GTPases: Promising Cellular Targets for Novel Anticancer Drugs
2006
Ras-homologous (Rho) GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. Rho GTPases are localized at membranes and become activated upon stimulation of cell surface receptors. In their GTP-bound (=active) state, Rho proteins bind to effector proteins, thereby triggering specific cellular responses. Members of the Rho family of small GTPases are key regulators of actin reorganization, cell motility, cell-cell and cell-extracellular matrix (ECM) adhesion as well as of cell cycle progression, gene expression and apoptosis. Each of these functions is of importance for the development and progression of cancer. Fu…
Chirurgische Ausbildung im digitalen Zeitalter – Virtual Reality, Augmented Reality und Robotik im Medizinstudium
2021
The digital transformation of healthcare is changing the medical profession. Augmented/Virtual Reality (AR/VR) and robotics are being increasingly used in different clinical contexts and require supporting education and training, which must begin within the medical school. There is currently a large discrepancy between the high demand and the number of scientifically proven concepts. The aim of this thesis was the conceptual design and structured evaluation of a newly developed learning/teaching concept for the digital transformation of medicine, with a special focus on the influence of surgical teaching.Thirty-five students participated in three courses of the blended learning curriculum "…
An Examination of the Relationship Between Coaches’ Transformational Leadership and Athletes’ Personal and Group Characteristics in Elite Youth Soccer
2021
There is a growing body of the literature highlighting the positive impact of transformational leadership behaviours across contexts, including sport. However, there is a lack of knowledge of this relationship within elite sport settings. Thus, the purpose of the present study was to examine the relationship between elite youth athletes’ perceptions of coaches’ transformational coaching-behaviours and variables that have been linked to transformational leadership in other settings (i.e., group cohesion, motivational climate, self-regulation of learning and athlete satisfaction). Norwegian elite youth soccer players (n= 753) selected into the national talent development program completed que…
Suomalaisen sosiaalipolitiikan ja liikuntapolitiikan yhtenevät päämäärät 1920-80-luvuilla
2018
Artikkelin tavoitteena on kuvailla sosiaalipolitiikan ja liikuntapolitiikan suhdetta sekä suhteessa tapahtuneita muutoksia suomalaisessa yhteiskunnassa 1920–80-luvuilla. Keskeisiä tutkimuskysymyksiä ovat (1) millaista samansuuntaista tavoitteellisuutta sosiaalipolitiikassa ja liikuntapolitiikassa on ilmennyt sekä (2) miten sosiaali- ja liikuntapoliittiset käsitykset politiikkalohkojen toimijoista ja toimijasuhteista ovat muuttuneet eri aikakausilla. Artikkelilla luodaan myös ymmärrystä väestön hyvinvoinnin edistämiseen liittyvän poikkihallinnollisen ja sektorirajat ylittävän yhteistyön historiasta sekä yhteistyöhön eri aikakausilla vaikuttaneista tekijöistä. Tutkimusmenetelmä on integroiva …
Tulevat ilmastot ja sosiaalityön etiikka
2018
Sosiaalityössä olisi kiireesti terävöitettävä tilallisesti ja ajallisesti kaukaisia toisia koskevaa etiikka, jotta ala kykenisi nykyistä paremmin reagoimaan globaaleihin tai ajan myötä kumuloituviin uhkiin ja niiden aiheuttamaan haavoittuvuuteen. Erityisen ajankohtaiseksi asian tekee ihmisen aiheuttama ilmastonmuutos, joka lisää jo nyt (noin +1⁰ esiteollisesta ajasta) eriarvoisuutta ja haavoittuvuutta esimerkiksi konfliktien, siirtolaisuuden, ruokapulan ja sairauksien taustatekijänä. Vaikka kukaan ei ole suojassa ilmaston lämpenemisen vaikutuksilta, kaikkein suojattomimpia ovat köyhät, marginalisoidut ja muuten haavoittuvissa asemissa olevat ihmiset, joiden resurssit suojautua ja sopeutua o…
Data practices and inequality in South African early childhood development policy: Technocratic management versus social transformation
2019
Background: In 1994, the African National Congress identified early childhood development as a potential strategy to redress the inequalities of apartheid, however, two and a half decades later, poverty still persists, and South Africa is one of the most unequal countries in the world. Aim: This article explores how policy texts based on and with the use of certain data practices establish ‘truths’ about childhoods and society, construct families and communities, and determine forms of provision to address inequality. Setting: In 2015, the South African government published the National Integrated Early Childhood Policy (NIECDP) to continue to address poverty and inequality. Its implementat…
Understanding the impact of digital on performing arts: a systematic literature review proposal
2023
Digital technologies have profoundly changed the cultural and creative industries. Due to the intrinsic characteristics of the performing arts sector, this digital transition has had a later impact on it. However, it has accelerated since the Covid-19 pandemic, forcing organizations to digitally transform themselves to keep in touch with their audience(s). Now that this crisis is over, many strategic and operational questions still remain unanswered. This research proposes a systematic literature review in order to establish the state of the art of the research on digitalization of the performing arts sector and to highlight the main research avenues to be explored.
Transformation of proliferative verrucous leukoplakia to oral carcinoma: a ten years follow-up
2004
Los autores presentan un caso de leucoplasia verrugosa proliferativa (LVP) en varón de 78 años de edad. Fue inicialmente presentado como un caso de leucoplasia en lengua pero un estudio microscópico en 1991 reveló la presencia de displasia epitelial leve. Tras 5 años de seguimiento, la lesión sufrió cambios de tamaño y localización y tuvo comportamiento recidivante. En 1996, un área eritematosa granular e indurada que apareció en lengua resultó ser un carcinoma de células escamosas microinvasivo cuando se estudió microscópicamente. Tras una revisión del comportamiento clinicopatológico de esta entidad, los autores concluyeron que se trataba de una leucoplasia verrugosa proliferativa, cuyo d…