Search results for "TRANSFORMATION"
showing 10 items of 1634 documents
Technology-Supported Guidance Models Stimulating the Development of Critical Thinking in Clinical Practice: Protocol for a Mixed Methods Systematic R…
2020
BackgroundCritical thinking is an essential skill that nursing students need to develop. Technological tools have opened new avenues for technology-supported guidance models, but the challenges and facilitators of such guidance models, as well as how they stimulate the development of critical thinking, remain unclear.ObjectiveWe developed a protocol for a mixed methods systematic review to investigate the use of technology-supported guidance models that stimulate the development of critical thinking in nursing education clinical practice.MethodsA convergent integrated design following the Joanna Briggs Institute Manual for Evidence Synthesis will be employed. A pair of authors will select t…
Iterative Symmetry Detection: Shrinking vs. Decimating Patterns
2005
This paper introduces a new mechanism that consists of applying a symmetry operator on an iteratively transformed version of the input image. The nature of the transformation characterizes the operator. Here, we consider the Object Symmetry Transform combined with the morphological operator erosion and the pyramid decimation respectively. The derived operators have been applied on both binary and gray levels images, comparing their ability to grasp the internal structure of a digital object. We present some experiments to evaluate their performances and check them for result quality versus computing complexity.
Integration of Two Multiobjective Optimization Methods for Nonlinear Problems
2003
In this paper, we bring together two existing methods for solving multiobjective optimization problems described by nonlinear mathematical models and create methods that benefit from both heir strengths. We use the Feasible Goals Method and the NIMBUS method to form new hybrid approaches. The Feasible Goals Method (FGM) is a graphic decision support tool that combines ideas of goal programming and multiobjective methods. It is based on the transformation of numerical information given by mathematical models into a variety of feasible criterion vectors (that is, feasible goals). Visual interactive display of this variety provides information about the problem that helps the decision maker to…
Towards a Holistic Approach to Retrofitting: A Critical Review of Stateof-the-art Evaluation Methodologies for Architectural Transformation
2017
The building sector is well known to be responsible for a considerable part of the total European energy consumption. In the endeavor to implement radical reductions, there is an identified potential in addressing the existing building stock through deep renovations. These renovations make up complex, highly interdisciplinary systems. They involve stakeholders across a broad spectrum of disciplines and potentially affect the lives of a large number of occupants. The involved people bring different understandings of value in sustainability into a project and judge the outcome according to this understanding. As a response to this, a number of sustainable assessment methodologies for the buil…
Identification of the Biotransformation Products of 2-Ethylhexyl 4-(N,N-Dimethylamino)benzoate
2010
Nowadays, 2-ethylhexyl 4-(N,N-dimethylamino)benzoate (EDP) is one of the most widely used UV filters in sunscreen cosmetics and other cosmetic products. However, undesirable processes such as percutaneous absorption and biological activity have been attributed to this compound. The in vitro metabolism of EDP was elucidated in the present work. First of all, the phase I biotransformation was studied in rat liver microsomes and two metabolites, N,N-dimethyl-p-aminobenzoic acid (DMP) and N-monomethyl-p-aminobenzoic acid (MMP), were identified by GC-MS analysis. Secondly, the phase II metabolism was investigated by means of LC-MS. The investigated reactions were acetylation and glucuronidation …
Epistemic Relativity: An Experimental Approach to Physics
2019
The recent concept of relativistic positioning system (RPS) has opened the possibility of making Relativity the general standard frame in which to state any physical problem, theoretical or experimental. Because the velocity of propagation of the information is finite, epistemic relativity proposes to integrate the physicist as a truly component of every physical problem, taking into account explicitly what information, when and where, the physicist is able to know. This leads naturally to the concept of relativistic stereometric system (RSS), allowing to measure the intrinsic properties of physical systems. Together, RPSs and RSSs complete the notion of laboratory in general relativity, al…
Imaging to study solid tumour origin and progression: lessons from research and clinical oncology
2017
Biomedical imaging in recent decades has clarified our understanding of normal and pathological cellular processes in vivo. In particular, this approach recently provided insights into processes occurring at a molecular or genetic level rather than at the anatomical level. The evolution of this discipline by engineering have led to its integration into biomedical research to (1) increase sensitivity and resolution imaging and to (2) improve tissue and cell specificity. Currently, imaging approaches are used in three different biomedical areas: (a) identification of cellular processes in physiological and disease state; (b) in vivo single-cell imaging; and (c) identification of new prognosti…
Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways.
1999
The aim of this study was to re-examine the human hepatic metabolism of diclofenac, with special focus on the generation of minor hydroxylated metabolites implicated in the idiosyncratic hepatotoxicity of the drug. Different experimental approaches were used: human hepatocytes, human microsomes, and engineered cells expressing single human CYP (cytochromes P450). Human hepatocytes formed 3'-hydroxy-, 4'-hydroxy-, 5-hydroxy- 4',5-dihydroxy-, and N,5-dihydroxydiclofenac, as well as several lactams. Formation of 4'- and 5-hydroxydiclofenac by human liver microsomes followed a Michaelis-Menten kinetics (Km 9 +/- 1 microM; Vmax 432 +/- 15 pmol/min/mg and Km 43 +/- 5 microM; and Vmax 15.4 +/- 0.6…
A fugacity model assessment of ibuprofen, diclofenac, carbamazepine, and their transformation product concentrations in an aquatic environment
2018
An updated version of FATEMOD, a multimedia fugacity model for environmental fate of organic chemicals, was set up to assess environmental behaviour of three pharmaceuticals in northern Lake Päijänne, Finland. Concentrations of ibuprofen, diclofenac, and carbamazepine were estimated at various depths at two sites: near a wastewater treatment plant and 3.5 km downstream the plant. When compared with environmental sampling data from corresponding depths and sites, the predicted concentrations, ranging from nanograms to hundreds of nanograms per litre, were found to be in good agreement. Weather data were utilised with the model to rationalise the effects of various environmental parameters on…
Functional implications of bound phenolic compounds and phenolics–food interaction: A review
2022
Sizeable scientific evidence indicates the health benefits related to phenolic compounds and dietary fiber. Various phenolic compounds-rich foods or ingredients are also rich in dietary fiber, and these two health components may interrelate via noncovalent (reversible) and covalent (mostly irreversible) interactions. Notwithstanding, these interactions are responsible for the carrier effect ascribed to fiber toward the digestive systemand canmodulate the bioaccessibility of phenolics, thus shaping health-promoting effects in vivo. On this basis, the present review focuses on the nature, occurrence, and implications of the interactions between phenolics and food components. Covalent and nonc…