Search results for "TREATMENT"
showing 10 items of 17623 documents
NMR-based quantification of rosmarinic and carnosic acids, GC-MS profile and bioactivity relevant to neurodegenerative disorders of Rosmarinus offici…
2013
Abstract A comparative study of phytochemicals content and biological properties of eight Rosmarinus officinalis (rosemary) populations (RO1–RO8) collected in different areas of Tunisia was carried out. Two of the main rosemary constituents, rosmarinic and carnosic acids, were quantified by an NMR technique. Carnosic acid content was higher than that of rosmarinic acid. The non-polar constituents were examined by GC and GC–MS. Total phenols and flavonoids content were also determined in order to discuss the possible correlation between these phytochemicals and bioactivity. Antioxidant activity was investigated through different in vitro assays. Sample RO3 from a sub-humid area showed the hi…
Current status and development of sanitation and wastewater treatment in the national and international context
2012
El acceso al saneamiento y depuración de aguas residuales es un aspecto de suma importancia tanto desde el punto de vista ambiental como sanitario. Por ello, desde el Imperio Mesopotámico hasta la actualidad se han producido importantes avances en esta materia. Sin embargo, en la actualidad, en la mayoría de los países en vías de desarrollo el acceso al saneamiento continua siendo deficitario. Por otra parte, los países desarrollados, que sí disponen de sistemas adecuados de depuración de aguas residuales, se enfrentan al reto de mejorar la sostenibilidad de estos sistemas. En este trabajo se describe en profundidad el estado actual y evolución en el tiempo del saneamiento y depuración de a…
Safety of Tyrosine Kinase Inhibitors in Patients With Differentiated Thyroid Cancer: Real-World Use of Lenvatinib and Sorafenib in Korea
2019
Background: Thyroid cancer has become the most common cancer in Korea. Generally, thyroid cancer patients have a good prognosis; however, 15–20% of patients experience recurrence or distant metastasis or are refractory to standard treatment. We assessed the safety of sorafenib and lenvatinib in patients with advanced or metastatic radioactive iodine-refractory differentiated thyroid cancers (DTC) consecutively treated at a tertiary center in South Korea.Methods: We retrospectively reviewed the charts of all consecutive patients with DTC treated during ≥6 months with lenvatinib (February 2016–April 2018) and sorafenib (January 2014–April 2018) at Gangnam Severance Hospital. Patients were tre…
Safety and immunogenicity of the PRAME cancer immunotherapeutic in metastatic melanoma: results of a phase I dose escalation study
2016
Purpose The PRAME tumour antigen is expressed in several tumour types but in few normal adult tissues. A dose-escalation phase I/II study (NCT01149343) assessed the safety, immunogenicity and clinical activity of the PRAME immunotherapeutic (recombinant PRAME protein (recPRAME) with the AS15 immunostimulant) in patients with advanced melanoma. Here, we report the phase I dose-escalation study segment. Patients and methods Patients with stage IV PRAME-positive melanoma were enrolled to 3 consecutive cohorts to receive up to 24 intramuscular injections of the PRAME immunotherapeutic. The RecPRAME dose was 20, 100 or 500 µg in cohorts 1, 2 and 3, respectively, with a fixed dose of AS15. Advers…
Tenapanor for the treatment of irritable bowel syndrome with constipation.
2020
Introduction: Irritable bowel syndrome with constipation is associated with higher rates of functional impairment, as compared to other subtypes of the syndrome. Conventional laxative-based pharmacologic therapy of IBS-C, which is mostly symptom-based, is often unsatisfactory. Tenapanor represents a first-in-class orally available inhibitor of NHE3, which is minimally absorbed in the GI tract, what constitutes a significant therapeutic benefit, as it may act on the drug target. Areas covered: Aim of this article is to sum up the evidences about pharmacodynamics and pharmacokinetics of tenapanor, focusing on animal models and in vitro studies, but also discuss clinical trials on tenapanor's …
Systematic review and exploratory meta-analysis of the efficacy, safety, and biological effects of psychostimulants and atomoxetine in patients with …
2019
ObjectiveOur aim was to summarize the efficacy and safety of atomoxetine, amphetamines, and methylphenidate in schizophrenia.MethodsWe undertook a systematic review, searching PubMed/Scopus/Clinicaltrials.gov for double-blind, randomized, placebo-controlled studies of psychostimulants or atomoxetine in schizophrenia published up to 1 January 2017. A meta-analysis of outcomes reported in two or more studies is presented.ResultsWe included 22 studies investigating therapeutic effects of stimulants (k=14) or measuring symptomatic worsening/relapse prediction after stimulant challenge (k=6). Six studies of these two groups plus one additional study investigated biological effects of psychostimu…
Systematic review and meta-analysis of the efficacy and safety of minocycline in schizophrenia
2017
ObjectiveOur aim was to perform an updated systematic review and meta-analysis on the efficacy and safety of adjunctive minocycline as a treatment of schizophrenia.MethodsWe conducted a PubMed/Scopus database search from inception to 3 February 2016 for randomized, placebo-controlled trials (RCTs), open non-randomized studies, and case reports/series evaluating minocycline in patients with schizophrenia. Random-effects meta-analysis of positive, negative, depressive, and cognitive symptom rating scales, discontinuation and adverse effects rates calculating standardized mean difference (SMD), and risk ratios±95% confidence intervals (CI95%) were calculated.ResultsSix RCTs were eligible (mino…
THE EVOLUTION OF THE SEWAGE TREATMENT PROCESS IN ROMANIA IN THE LAST 30 YEARS: CASE STUDY RÂMNICU VÂLCEA
2012
The evolution of the sewage treatment process in Romania in the last 30 years: case study Râmnicu Vâlcea. Most studies made at national level in the domain of hydrology target the surface water topic, analyzing the hydrometric and hydrologic characteristics and the quality of the water for certain catchment areas. This paper aims instead the relatively new field of urban hydrology, more exactly the urban wastewater treatment process. The study is based on the observations made in the first half of the year 2010 at the wastewater treatment plant from Râmnicu Vâlcea and on the analysis of some relevant wastewater quality indicators before and after the treatment process for the period between…
Germination Pattern of Chamaerops humilis Seed after Short-Time Storage
2015
Dwarf fan palm (Chamaerops humilis) plays an important ecological role in the thermo Mediterranean vegetation stage, both in woodlands, xerophitic shrub communities and degraded ecosystems. Dwarf fan palm is typically propagated from seeds. Whereas other palm species show reduced germination after few months of seed storage, no information is available on the effects of storage time on seed germinability . We examined the germination pattern of dwarf palm seeds aged after a storage of four, six or eight months in comparison to fresh seed (control). A covariance analysis was performed to test the effect of time within seed-storage treatment. The germination patterns were significantly fitted…