Search results for "TRES"

Rho GTPases Are Involved in the Regulation of NF-κB by Genotoxic Stress

2001

A common cellular response to genotoxic agents and inflammatory cytokines is the activation of NF-kappaB. Here, we addressed the question of whether small GTPases of the Rho family are involved in the stimulation of NF-kappaB signaling by genotoxic agents or TNFalpha in HeLa cells. Inhibition of isoprenylation of Rho proteins by use of the HMG-CoA reductase inhibitor lovastatin attenuated UV-, doxorubicin-, and TNFalpha-induced degradation of IkappaBalpha as well as drug-stimulated DNA binding activity of NF-kappaB. Furthermore, NF-kappaB-regulated gene expression stimulated by either UV irradiation or treatment with TNFalpha was abrogated by lovastatin pretreatment. This indicates that iso…

Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway.

2003

Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that mediate phospholipase D (PLD) activation in brain, but the mechanism underlying this response remains unclear. Here we used primary cultures of astrocytes as a cell model to explore the mechanism that links mGluRs to PLD. Glutamate activated both phospholipase C (PLC) and PLD with equal potency and this effect was mimicked by L-cysteinesulfinic acid, a putative neurotransmitter previously shown to activate mGluRs coupled to PLD, but not PLC, in adult brain. PLD activation by glutamate was dependent on Ca(2+) mobilization and fully blocked by both protein kinase C (PKC) inhibitors and PKC down-regulation, suggesti…

Inhibition of Protein Isoprenylation Impairs Rho-Regulated Early Cellular Response to Genotoxic Stress

2000

Activation of c-Jun N-terminal kinases (JNKs) and nuclear factor-kappaB (NF-kappaB) are early cellular responses to genotoxic stress involved in the regulation of gene expression. Pretreatment of cells with the hydroxymethyl glutaryl-CoA reductase inhibitor lovastatin blocked stimulation of JNK1 activity by UV irradiation and by treatment with the alkylating compound methyl methanesulfonate but did not affect activation of extracellular signal-regulated kinase 2 by UV light. Lovastatin also attenuated UV-induced degradation of the NF-kappaB inhibitor IkappaBalpha. The effects of lovastatin on UV-triggered stimulation of JNK1 as well as on IkappaBalpha degradation were reverted by cotreatmen…

The influence of the tecnique of rowing in the management of the rib stress injury in the rowers

2010

Per un approccio non riduttivistico allo stress lavoro-correlato: un questionario per i contesti ospedalieri mirato alla rilevazione della tematica b…

2012

Le recenti urgenze adempitive relative allo stress lavoro-correlato hanno favorito la tendenza a realizzare interventi fondati su implicite visioni dello stress come fenomeno autonomo rispetto alla dinamica psicosociale e culturale dell’organizzazione. Gli obblighi normativi possono invece rivelarsi occasioni per promuovere la diffusione di una cultura dello sviluppo e dell’empowerment organizzativo proponendo ai committenti una visione del ‘buon lavoro’ centrata non solo sulla assenza di disagio, ma anche sulla presenza di benessere, e la possibilità di realizzare interventi di ricerca-azione che si concretizzino in un accompagnamento delle organizzazioni verso la capacità di apprendere su…

Teknologian käytön pimeä puoli : mobiilin teknostressin vaimentamisen mekanismeja

2016

Tietotekniikan levittäytyminen elämän eri osa-alueille, sen halpeneminen ja arkipäiväistyminen ovat johtaneet myös negatiivisiin seurauksiin. Julkisessa keskustelussa ja akateemisessa kirjallisuudessa on mainittu teknologian käytön negatiiviselle, eli ”pimeälle puolelle” useita ilmentymiä. Teknologialle on esimerkiksi ominaista altistaa käyttäjänsä liian suurelle tietomäärälle, keskeytyksille, addiktiolle ja stressille. Teknostressinä tunnettuun häiriötilaan johtavia stressitekijöitä ovat mm. teknologian monimutkaisuus, ylikuormitus ja epävarmuus. Viimeaikainen teknostressitutkimus on kuitenkin pääasiassa keskittynyt selvittämään vain työelämässä koetun teknostressin syitä ja seurauksia. Ty…

Use of Hybrid Methods (Hole-Drilling and Ring-Core) for the Analysis of the RS on Welded Joints

2022

The hybrid methods (HMs) for the residual stress (RS) analysis, such as the well-known hole-drilling method (HDM) and the ring-core method (RCM), have been widely developed since 80’. They are mechanical methods based on the partial relaxation of the RSs that occur when a proper geometry variation of the analysed component is introduced by drilling a hole (HDM) or a proper annular groove (RCM). The RS computation is performed by measuring the strains relaxed on surface and then by combine properly such measured strains with the influence coefficients previously computed accurately by using a numerical codes that consider the geometry of the particular component to be examined. In such a man…

Risk Perception of COVID-19, Religiosity, and Subjective Well-Being in Emerging Adults: The Mediating Role of Meaning-Making and Perceived Stress

2022

The pressured experienced due to COVID-19 for young people has become clearly visible in the domain of well-being. Although the psychological effects of the COVID-19 pandemic on emerging adults have been examined, little is known about the role played by risk perception and religiosity for their well-being. In addition, the mediating effects of meaning-making and perceived stress still need to be investigated. A total of 316 emerging adults (143 males and 173 females) participated in the present study. Using structural equation modeling (SEM) analysis, we showed that the relationship of risk perception of COVID-19 and religiosity with subjective well-being was largely mediated by meaning-m…

Ensiaskeleita : arjen käynnistyminen keskoslasten perheissä

2000

Entropic model application to identify cross-sectional flow effect on velocity distribution in a large amplitude meandering channel

2020

Abstract Literature shows the application of the entropy concept in open channels flow. No existing research has been addressed to the application of the entropy concept for evaluating the effect of secondary flow which especially develops in curved channels. The purpose of this paper is to explore the possibility to evaluate the effect of the secondary flow on the stream-wise velocity distribution starting only from the knowledge of the surface velocity and the entropic concept application. The analysis is conducted with the aid of data collected in a large-amplitude meandering laboratory flume for two different values of the width-to-depth ratio. Results show that the location of the maxi…