Search results for "TRIF"

The influence of solid retention time on IFAS-MBR systems: analysis of system behavior.

2018

A University of Cape Town Integrated Fixed-Film Activated Sludge Membrane Bioreactor (UCT-IFAS-MBR) pilot plant was operated at different values of the sludge retention time (SRT). Three SRTs were investigated at different durations: indefinitely, 30 and 15 days. The organic carbon, nitrogen and phosphorus removal, kinetic/stoichiometric parameters, membrane fouling tendency and sludge filtration properties were assessed. The findings showed that by decreasing the SRT, the pilot plant could maintain excellent carbon removal efficiencies throughout the experiments. In contrast, the biological carbon removal showed a slight nitrification and was slightly affected by the decrease of the SRT, s…

Comparative quantum chemistry study of the F-center in lanthanum trifluoride

2020

Abstract In this study we report the results of first principle quantum chemical modeling of electronic structure and spatial configuration of LaF3 crystal containing the F-center. Theoretical predictions of atomic and electronic properties of LaF3 are given by means of density functional theory. From our modeling we predict that the F-center placed at fluorine ion position between the lanthanum planes at tysonite LaF3 is the most energetically stable. In order to interpret the structure of the optical absorption spectrum of X-irradiated LaF3 we performed calculations of excited and transition states of the F-center within the embedded cluster formalism using time dependent density function…

Rapid Radiochemical Separation Procedures from Aqueous Solutions

1992

The state-of-the-art in the field of rapid radiochemical separation procedures is illustrated by two systems using aqueous solutions as input: ARCA, an apparatus for repetitive separations, and SISAK, a centrifuge system for continuous separations. Applications presented are: Solvent extraction of element 105 investigated with 34-s 262105 using ARCA, and decay scheme studies of the fission product 1.0-s 110Tc by means of SISAK.

Tandem gold self-relay catalysis for the synthesis of 2,3-dihydropyridin-4(1 H)-ones: combination of σ and π Lewis acid properties of gold salts.

2014

The dual ability of gold salts to act as π- and σ Lewis acids has been exploited in a tandem self-relay catalysis. Thus, triphenylphosphanegold(I) triflate mediated the intramolecular carbonyl addition of the amide functionality of homoprogargyl amides to a triple bond. The formation of a σ complex of the gold salt with the intermediate oxazine promoted a nucleophilic addition followed by a Petasis-Ferrier rearrangement. This tandem protocol, catalyzed by the same gold salt under the same reaction conditions, gave rise to the efficient synthesis of 2,3-dihydropyridin-4-(1 H)-ones, which contain a cyclic quaternary α-amino acid unit. The asymmetric version was performed by generating the sta…

Modeling the decay of nitrite oxidizing bacteria under different reduction potential conditions

2018

[EN] Autotrophic growth and decay rates of ammonium and nitrite oxidizing bacteria (AOB and NOB, respectively) have a significant impact on the design and on the process performance of wastewater treatment systems where nitrification occurs. Literature data on the separate decay rates of AOB and NOB is scarce and inconsistent. In this study, batch experiments based on respirometric techniques were conducted to determine the NOB decay rates under different oxidation-reduction potential conditions, in order to widen the understanding of nitrite dynamics. The decay rate measured under anoxic conditions was 85% lower than under aerobic conditions, whereas under anaerobic conditions the decay ra…

NADPH-diaphorase activity of nitric oxide synthase in the olfactory bulb: co-factor specificity and characterization regarding the interrelation to N…

1994

The neuronal form of the enzyme nitric oxide synthase (nNOS) synthesizes the messenger molecule nitric oxide (NO). In addition to NO formation, nNOS exhibits a so-called NADPH-diaphorase (NADPH-d) activity. This study focused on the characterization of NADPH-d activity with regard to NO formation in the rat olfactory bulb. In this area of the brain pronounced staining is localized in discrete populations of neuronal somata and in olfactory glomeruli. Diaphorase staining combined with demonstration of nNOS by polyclonal antibodies revealed that NADPH-d activity of neuron somata is associated with nNOS immunoreactivity. It is concluded that neuron somata exhibit NADPH-d activity of nNOS. NAD…

Rotor—frame contact in a centrifuge installed on board a ship

2009

The criticality of rotor and stator contact in a large-size marine separator is studied by numerical modelling. Two plausible mechanisms leading to such contact, namely rolling of a ship in steady-state motion and a suddenly occurring unbalance in the rotor, are considered. It is found that contact due to sea motion may be tolerable, while sudden development of unbalance at operating speed can lead to unacceptably high contact forces. This agrees with experience of centrifugal separators operating on board of ships.

Trifluridine/tipiracil in earlier lines of chemotherapy for advanced colorectal cancer

2020

Prognostic Value of Sarcopenia in Metastatic Colorectal Cancer Patients Treated with Trifluridine/Tipiracil

2021

Sarcopenia is common in metastatic colorectal cancer (mCRC), increases the risk of treatment-related toxicity and reduces survival. Trifluridine/tipiracil (TT) chemotherapy significantly improved survival in refractory mCRC patients, but the prognostic and predictive role of pretherapeutic sarcopenia and variation in the skeletal muscle index (SMI) during this treatment has not been investigated so far. In this retrospective, observational study, clinical data on mCRC patients treated with TT at six cancer centres in Poland were collected. Computed tomography (CT) scans acquired at the time of initiation of TT (CT1) and on the first restaging (CT2), were evaluated. SMI was assessed based on…

TAS-102 in metastatic colorectal cancer (mCRC): efficacy, tolerability, and quality of life in heavily pretreated elderly patients: a real-life study

2020

Background: TAS-102 is an oral monotherapy, combining trifluridine and tipiracil hydrochloride, indicated for the treatment of pretreated metastatic colorectal cancer (mCRC). The aim of this real-life study is to evaluate the efficacy and safety of TAS-102 in heavily pretreated elderly patients with mCRC whose disease has progressed with standard therapies. Methods: In this retrospective observational study, we enrolled 50 elderly patients >70 years of age (median age 78 years) with a diagnosis of mCRC who were previously treated or were not considered candidates for treatment with other available therapies. Patients aged >70 years with advanced colorectal cancer and with an ECOG perf…