Search results for "TRIF"
showing 10 items of 1419 documents
Retrospective Study of Regorafenib Versus TAS-102 Efficacy and Safety in Chemorefractory Metastatic Colorectal Cancer (mCRC) Patients: A Multi-instit…
2021
INTRODUCTION: There have been significant developments in colorectal cancer (CRC) research over the last few years, with the introduction of new agents that have been prolonged median overall survival of metastatic colorectal cancer (mCRC). These therapies have improved patient outcomes; however, despite significant progress in strategies for cancer treatment, their use is limited by development of resistant mechanism. Almost 30% of patients with refractory mCRC will remain good candidates for further treatment. Regorafenib and TAS-102 are novel antitumor agents for patients with refractory mCRC. However, it is unclear which patients may derive a survival benefit from these drugs in real-li…
Late-line treatment in metastatic gastric cancer: today and tomorrow.
2019
Survival for patients with unresectable advanced or recurrent gastric cancer (GC) remains poor and the historical lack of evidence-based therapeutic options after second-line therapy is reflected in current clinical guidelines for this condition. Despite uncertainty about optimal therapeutic strategies, further treatment is appropriate for some patients after failure of second line and may prolong survival. This approach has been reported in clinical trials and is becoming more common in real-world clinical settings. Several prognostic factors may increase the likelihood that a patient will be eligible for treatment in the third-line setting, including geographic location, status at diagno…
Genetic characterization of the nitrate reducing community based on narG nucleotide sequence analysis.
2003
The ability of facultative anerobes to respire nitrate has been ascribed mainly to the activity of a membrane-bound nitrate reductase encoded by the narGHJI operon. Respiratory nitrate reduction is the first step of the denitrification pathway, which is considered as an important soil process since it contributes to the global cycling of nitrogen. In this study, we employed direct PCR, cloning, and sequencing of narG gene fragments to determine the diversity of nitrate-reducing bacteria occurring in soil and in the maize rhizosphere. Libraries containing 727 clones in total were screened by restriction fragment analysis. Phylogenetic analysis of 128 narG sequences separated the clone famili…
A multivariate approach of changes in filamentous, nitrifying and protist communities and nitrogen removal efficiencies during ozone dosage in a full…
2019
[EN] The application of low ozone dosage to minimize the problems caused by filamentous foaming was evaluated in two bioreactors of an urban wastewater treatment plant. Filamentous and nitrifying bacteria, as well as protist and metazoa, were monitored throughout a one-year period by FISH and conventional microscopy to examine the effects of ozone application on these specific groups of microorganisms. Multivariate data analysis was used to determine if the ozone dosage was a key factor determining the low carbon and nitrogen removal efficiencies observed throughout the study period, as well as to evaluate its impact on the biological communities monitored. The results of this study suggest…
Depletion of ozone and reservoir species of chlorine and nitrogen oxide in the lower Antarctic polar vortex measured from aircraft
2017
Novel airborne in situ measurements of inorganic chlorine, nitrogen oxide species, and ozone were performed inside the lower Antarctic polar vortex and at its edge in September 2012. We focus on one flight during the Transport and Composition of the LMS/Earth System Model Validation (TACTS/ESMVal) campaign with the German research aircraft HALO (High-Altitude LOng range research aircraft), reaching latitudes of 65°S and potential temperatures up to 405 K. Using the early winter correlations of reactive trace gases with N2O from the Atmospheric Chemistry Experiment-Fourier Transform Spectrometer (ACE-FTS), we find high depletion of chlorine reservoir gases up to ∼40% (0.8 ppbv) at 12 km to 1…
Ložņu āboliņa (Trifolium repens L.) Eiropas populāciju ģenētiskās daudzveidības salīdzinājums
2021
Ložņu āboliņam ir plašs izplatības areāls – no arktiskiem reģioniem līdz augstkalnu (6000 m) reģioniem. Tas ir plaši izplatīts arī vietās ar augstu vides piesārņojuma līmeni. Maģistra darba mērķis ir noteikt ložņu āboliņa Eiropas populāciju ģenētisko daudzveidību atkarībā no dažādiem augšanas apstākļiem. Ģenētiskās daudzveidības noteikšanai tika izmantota iPBS metode un izstrādāta metode UV-B starojuma izraisītas retrotranspozonu pārvietošanās noteikšanai. Rezultāti liecina, ka analizētā Eiropas populācija iedalās divos lielos klāsteros, atsevišķi izdaloties augstkalnu apgabalam. Secināts, ka augstkalnu reģionos izplatītās populācijas ģenētiski ir atšķirīgas no zemienēs izplatītājām. Analiz…
Potential of interactive multiobjective optimization in supporting the design of a groundwater biodenitrification process
2019
The design of water treatment plants requires simultaneous analysis of technical, economic and environmental aspects, identified by multiple conflicting objectives. We demonstrated the advantages of an interactive multiobjective optimization (MOO) method over a posteriori methods in an unexplored field, namely the design of a biological treatment plant for drinking water production, that tackles the process drawbacks, contrarily to what happens in a traditional volumetric-load-driven design procedure. Specifically, we consider a groundwater denitrification biofilter, simulated by the Activated Sludge Model modified with two-stage denitrification kinetics. Three objectives were defined (nitr…
The battle for the ninth ward. L’esperienza partecipativa della nona circoscrizione dopo l’uragano Katrina
2012
Attraverso il racconto dei processi e movimenti che hanno visto attori gli abitanti di New Orleans dopo il passaggio dell’uragano Katrina del 2005, racconto effettuato da Wade Rathke, fondatore dell’Association of Community Organizationsg for Reform Now (ACORN) e organizzatore di esperienze di gruppo della ACORN International, si trattano i processi di partecipazione attiva e sulla modalità con cui questi possono contribuire ai processi di pianificazione e ricostruzione. La movimentazione nasce per resistere a processi di gentrification legati alla riqualificazione urbana e a forti pressioni speculative e si trasferiscono nell’esperienza del Piano presentato dalla ACORN, “The People’s Plan …
Centrifugal necrotic keratoacanthoma
2007
Centrifugal necrotic keratoacanthoma is a quite rare variant of keratoacanthoma, with a locally aggressive behavior and no tendency to spontaneous involution. We report a typical case of the nasal-orbital region. Based on its clinical, histological and behavioral picture, centrifugal necrotic keratoacanthoma appears as variant of giant keratoacanthoma and can be regarded as an intermediate form in a spectrum where keratoacanthoma and overt squamous cell carcinoma represent the most benign and the most malignant end, respectively, as also highlighted by analogies between the two lesions recently reported in the field of molecular biology.
The human peroxisome in health and disease: The story of an oddity becoming a vital organelle
2013
Abstract Since the first report by Rhodin in 1954, our knowledge on mammalian microbodies/peroxisomes has known several periods. An initial two decades period (1954–1973) has contributed to the biochemical individualisation of peroxisomes as a new class of subcellular organelles (de Duve, 1965). The corresponding research period failed to define a clear role of mammalian peroxisomes in vital functions and intermediary metabolism, explaining why feeling that peroxisomes might be in the human cell oddities has prevailed during several decades. The period standing from 1973 to nowadays has progressively removed this cell oddity view of peroxisomes by highlighting vital function and metabolic r…