Search results for "TRIP"

Oxygen Atom Transfer Catalysis by Dioxidomolybdenum(VI) Complexes of Pyridyl Aminophenolate Ligands

2021

A series of new cationic dioxidomolybdenum(VI) complexes [MoO2(Ln)]PF6 (2-5) with the tripodal tetradentate pyridyl aminophenolate ligands HL2-HL5 have been synthesized and characterized. Ligands HL2-HL4 carry substituents in the 4-position of the phenolate ring, viz. Cl, Br and NO2, respectively, whereas the ligand HL5, N-(2-hydroxy-3,5-di-tert-butylbenzyl)-N,N-bis(2-pyridylmethyl)amine, is a derivative of 3,5-di-tert-butylsalicylaldehyde. X-ray crystal structures of complexes 2, 3 and 5 reveal that they have a distorted octahedral geometry with the bonding parameters around the metal centres being practically similar. Stoichiometric oxygen atom transfer (OAT) properties of 5 with PPh3 wer…

Tiedon omistaminen on valtaa : globalisoituvan patenttijärjestelmän poliittinen moraalitalous ja globaali kapitalismi

2008

Globalisoituvassa patenttijärjestelmässä ei ole kyse globaalin kapitalismin teknisestä yksityiskohdasta, vaan merkittävästä yhteiskunnallisesta kysymyksestä. Tämän havaitsi Ilkka Kauppinen sosiologian väitöskirjassaan tutkiessaan globalisoituvaa patenttijärjestelmää ja Maailman kauppajärjestön (WTO) vuonna 1994 hyväksymää sopimusta teollis- ja tekijänoikeuksien kauppaan liittyvistä näkökohdista (TRIPS).Kehitysmaissa elävien ihmisten kannalta ongelmallisimmat patentit koskevat esimerkiksi maataloutta ja lääketeollisuutta, koska patentit mahdollistavat näillä aloilla tuotettavien elintärkeiden hyödykkeiden monopolihinnoittelun. Patenttijärjestelmällä on yhteytensä myös ilmastonmuutokseen, kos…

Viaggi multi-destinazione in Sicilia: principali determinanti ed effetti distorcenti nelle statistiche sul turismo

2013

Neridronate prevents bone loss in patients receiving androgen deprivation therapy for prostate cancer.

2004

Today, androgen deprivation therapy is a cornerstone of treatment for advanced prostate cancer, although it presents important complications such as osteoporosis. Neridronate, a relatively new bisphosphonate, is able to prevent bone loss in patients with prostate cancer during androgen ablation. Introduction: Androgen-deprivation therapy (ADT) is a cornerstone of treatment for advanced prostate cancer. This therapy has iatrogenic complications, such as osteoporosis. The aim of our study was to evaluate the efficacy of neridronate, a relatively new bisphosphonate, to prevent bone loss during androgen ablation. Materials and Methods: Forty-eight osteoporotic patients with prostate cancer, tre…

Blends of Semiflexible Polymers: Interplay of Nematic Order and Phase Separation

2021

Mixtures of semiflexible polymers with a mismatch in either their persistence lengths or their contour lengths are studied by Density Functional Theory and Molecular Dynamics simulation. Considering lyotropic solutions under good solvent conditions, the mole fraction and pressure is systematically varied for several cases of bending stiffness κ (the normalized persistence length) and chain length N. For binary mixtures with different chain length (i.e., NA=16, NB=32 or 64) but the same stiffness, isotropic-nematic phase coexistence is studied. For mixtures with the same chain length (N=32) and large stiffness disparity (κB/κA=4.9 to 8), both isotropic-nematic and nematic-nematic unmixing oc…

Adjuvant capecitabine in triple negative breast cancer patients with residual disease after neoadjuvant treatment: real-world evidence from CaRe, a m…

2023

BackgroundIn triple negative breast cancer patients treated with neoadjuvant chemotherapy, residual disease at surgery is the most relevant unfavorable prognostic factor. Current guidelines consider the use of adjuvant capecitabine, based on the results of the randomized CREATE-X study, carried out in Asian patients and including a small subset of triple negative tumors. Thus far, evidence on Caucasian patients is limited, and no real-world data are available.MethodsWe carried out a multicenter, observational study, involving 44 oncologic centres. Triple negative breast cancer patients with residual disease, treated with adjuvant capecitabine from January 2017 through June 2021, were recrui…

Effects of obesity and estradiol on Na+/K+-ATPase and their relevance to cardiovascular diseases

2013

Obesity is associated with aberrant sodium/potassium-ATPase (Na+/K+-ATPase) activity, apparently linked to hyperglycemic hyperinsulinemia, which may repress or inactivate the enzyme. The reduction of Na+/K+-ATPase activity in cardiac tissue induces myocyte death and cardiac dysfunction, leading to the development of myocardial dilation in animal models; this has also been documented in patients with heart failure (HF). During several pathological situations (cardiac insufficiency and HF) and in experimental models (obesity), the heart becomes more sensitive to the effect of cardiac glycosides, due to a decrease in Na+/K+-ATPase levels. The primary female sex steroid estradiol has long been …

Silver Sulfide Nanoclusters and the Superatom Model

2015

The superatom model of electron-shell closings has been widely used to explain the stability of noble-metal nanoclusters of few nanometers, including thiolate-protected Au and Ag nanoclusters. The presence of core sulfur atoms in silver sulfide (Ag–S) nanoclusters renders them a class of clusters with distinctive properties as compared to typical noble-metal clusters. Here, it is natural to ask whether the superatom model is still applicable for the Ag–S nanoclusters with mixed metal and nonmetal core atoms. To address this question, we applied density functional simulations to analyze a series of Ag–S nanoclusters: Ag14S(SPh)12(PPh3)8, Ag14(SC6H3F2)12(PPh3)8, Ag70S16(SPh)34(PhCO2)4(triphos…

Potential use of organotin(IV)-tripetide complexes as stopper in tumor cells growth.

2008

Pulsating B and Be stars in the Small Magellanic Cloud

2008

Context: Stellar pulsations in main-sequence B-type stars are driven by the kappa-mechanism due to the Fe-group opacity bump. The current models do not predict the presence of instability strips in the B spectral domain at very low metallicities. As the metallicity of the SMC is lower than Z=0.005, it constitutes a very suitable object to test these predictions. Aims: The main objective is to investigate the existence of B-type pulsators at low metallicities, searching for short-term periodic variability in absorption-line B and Be stars in the SMC. The analysis has been performed in a sample of 313 B and Be stars with fundamental astrophysical parameters accurately determined from high-res…