Search results for "TRIP"
showing 10 items of 2134 documents
Estudio de la utilidad clínica del perfil de estrés oxidativo en pacientes con déficit de alfa-1 antitripsina
2016
Introducción: Investigaciones recientes en modelos animales sugieren la participación del estrés oxidativo y el daño de oxidativo en la patogénesis del déficit de alfa 1 antitripsina (DAAT). Sin embargo, no hay datos disponibles sobre el estado de estrés oxidativo y la actividad de los enzimas antioxidantes en estos pacientes. Se sabe que el estrés oxidativo está implicado en la patogénesis de enfermedades en otros organismos (aterosclesosis, enfermedades neurodegenerativas, diabetes mellitus, enfermedades reumáticas, etc). También que el tabaco es un importante oxidante, disminuyendo la afinidad de la alfa-1 antitripsina, principal antiproteasa del organismo, por la elastasa del neutrófilo…
Synthesis, characterization, and cellular investigations of porphyrin– and chlorin–indomethacin conjugates for photodynamic therapy of cancer
2021
Indomethacin is a potent non-steroidal anti-inflammatory drug (NSAID) with a strong selective inhibitor activity towards cyclooxygenase-2 (COX-2), an enzyme that is highly overexpressed in various tumour cells, being involved in tumourigenesis. Concomitantly, porphyrins have gained much attention as promising photosensitizers (PSs) for the non-invasive photodynamic therapy (PDT) of cancer. Herein, we report the design, and determine the singlet oxygen generation capacity and in vitro cellular toxicity of porphyrin- and chlorin-indomethacin conjugates (P2-Ind and C2-Ind). Both the conjugates were obtained in high yields and were characterized by 1H, 19F and 13C NMR as well as by high resolut…
Impact of Platelet Reactivity in ACS Patients on Clinical Outcomes with Triple Antithrombotic Therapy
2021
Optimal antithrombotic therapy after percutaneous coronary intervention (PCI) in patients on oral anticoagulants (OAC) remains a clinical conundrum. In fact, combining an OAC with dual antiplatelet therapy (triple antithrombotic therapy, TAT) increases the risk of bleeding. Clopidogrel is the only thienopyridine recommended in TAT patients. Whether its response plays a relevant role in this setting remains uncertain. We aimed to evaluate the level of platelet reactivity inhibition (PRI) achieved by oral TAT in Acute Coronary Syndrome (ACS) patients undergoing PCI and its relationship with outcomes. We performed a multicenter prospective observational study and assessed PRI by vasodilator-st…
Sponge‐Like Behaviour in Isoreticular Cu(Gly‐His‐X) Peptide‐Based Porous Materials
2015
We report two isoreticular 3D peptide-based porous frameworks formed by coordination of the tripeptides Gly-L-His-Gly and Gly-L-His-L-Lys to Cu(II) which display sponge-like behaviour. These porous materials undergo structural collapse upon evacuation that can be reversed by exposure to water vapour, which permits recovery of the original open channel structure. This is further confirmed by sorption studies that reveal that both solids exhibit selective sorption of H2 O while CO2 adsorption does not result in recovery of the original structures. We also show how the pendant aliphatic amine chains, present in the framework from the introduction of the lysine amino acid in the peptidic backbo…
Educación Geográfica y las salidas de campo como estrategia didáctica: un estudio comparativo desde el Geoforo Iberoamericano
2016
Las salidas de campo integran algunas de las principales estrategias didácticas y prácticas pedagógicas utilizadas por profesores de diferentes disciplinas escolares. En la Geografía, numerosas publicaciones académicas y experiencias de enseñanza han sido divulgadas en eventos científicos, artículos y libros. Haremos aquí un estudio de cómo las salidas de campo o visitas de estudio han sido abordadas en la educación geográfica en los países ibero-americanos, en especial en los estudios realizados en Brasil y España. El objeto que queremos abordar en este estudio tiene como núcleo básico el Foro 21, realizado en el Geoforo Iberoamericano, iniciado en febrero de 2015. En él se discutían las s…
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters
2002
In the present study, we addressed the question of a putative relevance of Rho proteins in tumour progression by analysing their expression on protein and mRNA level in breast tumours. We show that the level of RhoA, RhoB, Rac1 and Cdc42 protein is largely enhanced in all tumour samples analysed (n=15) as compared to normal tissues originating from the same individual. The same is true for 32P-ADP-ribosylation of Rho proteins which is catalysed by Clostridium botulinum exoenzyme C3. Also the amount of Rho-GDI and ERK2 as well as the level of overall 32P-GTP binding acvitity was tumour-specific elevated, yet to a lower extent than Rho proteins. Although the amount of Rho proteins was enhance…
El papel de las prácticas sostenibles en las relaciones entre empresas. Un análisis en el transporte marítimo
2023
La intensa competencia en el transporte marítimo ha obligado a las navieras a diseñar estrategias enfocadas en las necesidades de los clientes. Bajo este contexto, la literatura señala que a través de las prácticas sostenibles es posible fortalecer las relaciones entre empresas a largo plazo; del mismo modo, también se apunta hacia otras variables relacionales, tales como el valor logístico, como impulsoras de la relación. No obstante, tanto la intensidad como los efectos que todo ello desencadena entre los distintos actores del sector del transporte marítimo de mercancías, permanecen inexplorados. Así, se observa la necesidad de realizar nuevos estudios que den luz, para sentar las bases e…
Defying Stereotypes with Nanodiamonds: Stable Primary Diamondoid Phosphines
2016
International audience; Direct unequal C-H bond difunctionalization of phosphorylated diamantane was achieved in high yield from the corresponding phosphonates. Reduction of the functionalized phosphonates provides access to novel primary and secondary alkyl/aryl diamantane phosphines. The prepared primary diamantyl phosphines are quite air stable compared to their adamantyl and especially alkyl or aryl analogues. This finding is corroborated by comparing the singly occupied molecular orbital energy levels of the corresponding phosphine radical cations obtained by density functional theory computations.
Characterization of IP-Based Communication for Smart Grid Using Software-Defined Networking
2018
The smart grid (SG) approach is based on a strong interaction between the network communication infrastructure and the power grid. Usually the management of the infrastructure is done by the distribution system operators (DSOs) that are worried about the increasing managing complexity due to the presence of increasing number of distributed energy resources and electrical vehicles. The use of software-defined networking (SDN) may simplify the network configuration and management for DSO, as highlighted from previous research works. The objective of this paper is to introduce and characterize an internet protocol (IP)-based communication architecture with specialized SDN bridges operating als…