Search results for "TRIP"
showing 10 items of 2134 documents
Increased Tumour Infiltration of CD4+ and CD8+ T-Lymphocytes in Patients with Triple Negative Breast Cancer Suggests Susceptibility to Immune Therapy
2017
Background: Patients with triple negative breast cancer (TNBC) have limited therapeutic options, largely because the complex tumour environment is not well-characterized. These patients are potential, but largely un-fathomed, candidates for immunotherapy. It is therefore highly relevant to characterize leukocyte complexity in TNBCs. Objective: To investigate leukocyte complexity in tumour environment of patients with TNBCs. Materials and methods: A total of 104 consecutive breast cancer patients undergoing mastectomy were recruited in the study after ethical approval. Clinico-pathological parameters were recorded and H and E staining was performed to investigate tumour morphology. Receptor …
CCDC 190421: Experimental Crystal Structure Determination
2003
Related Article: D.Gudat, B.Lewall, M.Nieger, I.Detmer, L.Szarvas, P.Saarenketo, G.Marconi|2003|Chem.-Eur.J.|9|661|doi:10.1002/chem.200390074
A Solar Photothermocatalytic approach for the CO2 conversion: Investigation of different synergisms on CoO-CuO/Brookite TiO2-CeO2 catalysts
2022
Abstract The photoactive features of the least common polymorph of TiO2, i.e. brookite, were combined with the thermocatalytic redox ones of cerium oxide, focusing on the effects of the addition of small amounts of Co-Cu oxides for the solar CO2 conversion. By considering the characterization data, a surface segregation of the hosted metal oxides on the TiO2-CeO2 composite was evidenced, and their presence increased the amount of oxygen vacancies and improved the charge carriers separation. The bimetallic oxides-based sample was the most performing one in the photocatalytic carbon dioxide reduction at room temperature. The formation of carbon monoxide and methane was 5 and 0.5 μmol g−1h−1, …
Decrease of mRNA levels and biosynthesis of sucrase-isomaltase but not dipeptidylpeptidase IV in forskolin or monensin-treated Caco-2 cells.
1991
International audience; Treatment for 48 h of differentiated, confluent Caco-2 cells with 2.5 10(-5) M forskolin or 10(-6) M monensin, which produces a significant decrease of the de novo biosynthesis of sucrase-isomaltase, does not change quantitatively the de novo biosynthesis of dipeptidylpeptidase IV. Western blot analysis and silver nitrate staining indicate that neither drug induces any modification in the steady state expression of these two brush border hydrolases. Northern blot analysis shows that the level of dipeptidylpeptidase IV mRNA does not change in treated as compared to control Caco-2 cells. In contrast, forskolin and monensin dramatically decrease the level of sucrase-iso…
A qualitative study on the role of the built environment for short walking trips
2015
The present study uses a qualitative approach with the aim to identify built environmental factors influencing short walking distances for transportation among adults (18-65 years), with special attention to micro-scale attributes. Three focus groups were held in Valencia (Spain) and conducted with participants who undertook, at least once a week, one short non-shopping trip in any travel mode (were "short trip" is defined as less than 3045 min walking distance). A thematic analysis of the data was performed and six categories of factors emerged related to the built environment. Factors were also classified as either barriers to walking, or secondary factors related to the attractiveness of…
Hauskasti puvuttomina : burleskin esteettisen vastarinnan traditio ja ilmiö Suomessa
2011
Tutkielmassani tarkastelen burleskin nykyilmiötä suhteessa sen historiallisiin juuriin, tyyliin ja traditioon esteettisen vastarinnan näkökulmasta etsien siitä vastakulttuurisia yhdessä nauramisen elementtejä. Tutkin, mitä historiallisten burleskien ja karnevalistisuuden piirteistä nykyilmiö yhä kantaa mukanaan, ja miten nykyburleski uudenlaisena, yhteisöllisenä, yksilöllisenä, heterogeenisenä, uudistavana ja uudistuvana esteettisen vastakulttuurin muotona liittyy erilaisten strategioiden kautta osaksi burleskin traditiota. Näkökulmani on useimpien aihetta käsittelevien tutkimusten naisnäkökulmasta poiketen laajemmin sukupuolen representaatioita, murroksia ja tulkintoja, sekä inhimillistä n…
Pharmaceutical patents and the right to access to medicines in Central America
2020
El vínculo entre la propiedad intelectual y el derecho a la salud se ha convertido en un tema de debate central desde la conferencia ministerial de la Organización Mundial del Comercio (OMC) en 2001. En efecto, a pesar del amplio reconocimiento del derecho a la salud en la escena internacional, la cuestión de la protección efectiva y la aplicación del derecho en cuestión es tema de un debate constante. El objetivo de las patentes farmacéuticas, es proporcionar al inventor un conjunto de derechos exclusivos durante un período de tiempo determinado a cambio de la divulgación pública del medicamento recién protegido. El régimen de monopolio establecido conduce a un aumento significativo de los…
MILES extended: Stellar population synthesis models from the optical to the infrared
2016
We present the first single-burst stellar population models which covers the optical and the infrared wavelength range between 3500 and 50000 Angstrom and which are exclusively based on empirical stellar spectra. To obtain these joint models, we combined the extended MILES models in the optical with our new infrared models that are based on the IRTF (Infrared Telescope Facility) library. The latter are available only for a limited range in terms of both age and metallicity. Our combined single-burst stellar population models were calculated for ages larger than 1 Gyr, for metallicities between [Fe/H] = -0.40 and 0.26, for initial mass functions of various types and slopes, and on the basis …
Supramolecular Construction of Cyanide-Bridged Re I Diimine Multichromophores
2019
The reactions of labile [Re(diimine)(CO)3(H2O)]+ precursors (diimine = 2,2′-bipyridine, bpy; 1,10-phenanthroline, phen) with dicyanoargentate anion produce the dirhenium cyanide-bridged compounds [{Re(diimine)(CO)3}2CN)]+ (1 and 2). Substitution of the axial carbonyl ligands in 2 for triphenylphosphine gives the derivative [{Re(phen)(CO)2(PPh3)}2CN]+ (3), while the employment of a neutral metalloligand [Au(PPh3)(CN)] affords heterobimetallic complex [{Re(phen)(CO)3}NCAu(PPh3)]+ (4). Furthermore, the utilization of [Au(CN)2]−, [Pt(CN)4]2–, and [Fe(CN)6]4–/3– cyanometallates leads to the higher nuclearity aggregates [{Re(diimine)(CO)3NC}xM]m+ (M = Au, x = 2, 5 and 6; Pt, x = 4, 7 and 8; Fe, x…
A Definitive Pharmacophore Modelling Study on CDK2 ATP Pocket Binders: Tracing the Path of New Virtual High-Throughput Screenings
2020
Cyclin Dependent Kinases-2 (CDK2) are members of serine/threonine protein kinases family. They play an important role in the regulation events of the eukaryotic cell division cycle, especially during the G1 to S phase transition. Experimental evidence indicate that excessive expression of CDK2s should cause abnormal cell cycle regulation. Therefore, since a long time, CDK2s have been considered potential therapeutic targets for cancer therapy. In this work, onehundred and forty-nine complexes of inhibitors bound in the CDK2-ATP pocket were submitted to short MD simulations (10ns) and free energy calculation. Comparison with experimental data (K<sub>i</sub>, K<sub>d</su…