Search results for "TYR"
showing 10 items of 2017 documents
BIBF 1120/ nintedanib : a new triple angiokinase inhibitor-directed therapy in patients with non-small cell lung cancer.
2013
Abstract: Introduction: Several new targeted agents with anti-angiogenic properties have been developed recently, including vandetanib, sunitinib, sorafenib, bevacizumab and others. Tumor development, progression, metastasis are strongly linked to angiogenesis. Targeted agents like bevacizumab, a monoclonal antibody which targets VEGF, have been fully developed in several solid tumors. These new agents strongly advocate that targeting angiogenesis is one of the best approaches for cancer therapy. Areas covered: Those agents that target additional pro-angiogenic intracellular signaling pathways beyond VEGF signaling have also the potential to contribute to anticancer therapies. The authors p…
Show me your signaling– and I’ll tell you who you are
2009
See Article, pages 725–733Cancer research and therapy have come a long way:the field started out in search of a ‘‘magic bullet” accord-ing to Paul Ehrlich’s theory, and was hoping to identifya target which was pivotal to signaling survival in trans-formed cells. Indeed, certain diseases with monocausalmutations were identified, and targeting of the muta-tional products has helped in the design of treatmentstrategies. In chronic myeloid leukemia (CML), the con-stitutive activation of the tyrosine kinase BCR-ABL ispathognomonic [1], and multiple BCR-ABL kinaseinhibitors (e.g. imatinib mesylate, dasatinib, nilotinib)have been developed and successfully used in the treat-ment of CML offering near-…
Conquests and perspectives of cardio-oncology in the field of tumor angiogenesis-targeting tyrosine kinase inhibitor-based therapy
2015
Abstract: Introduction: Angiogenesis is fundamental for tumor development and progression. Hence, anti-angiogenic drugs have been developed to target VEGF and its receptors (VEGFRs). Several tyrosine kinase inhibitors (TKIs) have been developed over the years and others are still under investigation, each anti-VEGFR TKI showing a different cardiotoxic profile. Knowledge of the cardiac side-effects of each drug and the magnitude of their expression and frequency can lead to a specific approach. Areas covered: This work reviews the mechanism of action of anti-VEGFR TKIs and the pathophysiological mechanisms leading to cardiotoxicity, followed by close examination of the most important drugs i…
Polymer-Functionalised Nanograins of Mg-Doped Amorphous Calcium Carbonate via a Flow-Chemistry Approach
2019
Calcareous biominerals typically feature a hybrid nanogranular structure consisting of calcium carbonate nanograins coated with organic matrices. This nanogranular organisation has a beneficial effect on the functionality of these bioceramics. In this feasibility study, we successfully employed a flow-chemistry approach to precipitate Mg-doped amorphous calcium carbonate particles functionalized by negatively charged polyelectrolytes&mdash
La costruzione tian (tun) + infinito nel dialetto tedesco di Merano*
2012
This article deals with the 'do-support' phenomenon in the German Tyrolean dialect spoken in Merano/Meran (Northern Italy). We show that it is used in various contexts, which do not correspond to the contexts in which English resorts to do-support. In some of these contexts the do-support is obligatory, while in others it is optional.
Plio-Quaternary tectonic evolution offshore the Capo Vaticano Promontory
2014
We reconstruct the Plio-Quaternary tectono-stratigraphic evolution in the offshore Capo Vaticano (W Calabria, Italy) by integrating data obtained from single- and multi-channel reflection seismic profiles and a reprocessed version of the CROP M2A/III line. NW-trending, high-angle normal faults, dipping ~70° to the south-west formed along the continental slope connecting the south-west continental shelf of the Capo Vaticano Promontory to the Gioia Tauro Basin (Pepe et al., 2014). Faults generally have small displacements up to 40 m and are sealed by Pleistocene deposits. West of the Capo Vaticano promontory and in the Gioia Basin, a SE-dipping, normal fault system, more than 32 km long, is r…
Southern-Tyrrhenian seismicity in space-time-magnitude domain
2006
An analysis is conducted on a catalogue containing more than 2000 seismic events occurred in the southern Tyrrhenian Sea between 1988 and October 2002, as an attempt to characterise the main seismogenetic processes active in the area in space, time and magnitude domain by means of the parameters of phenomenological laws. We chose to adopt simple phenomenological models, since the low number of data did not allow to use more complex laws. The two main seismogenetic volumes present in the area were considered for the purpose of this work. The first includes a nearly homogeneous distribution of hypocentres in a NW steeply dipping layer as far as a…
CCDC 917055: Experimental Crystal Structure Determination
2013
Related Article: Roshan Y. Nimje, Mikko V. Leskinen, Petri M. Pihko|2013|Angew.Chem.,Int.Ed.|52|4818|doi:10.1002/anie.201300833
CCDC 204502: Experimental Crystal Structure Determination
2004
Related Article: A.Volonterio, S.Bellosta, F.Bravin, M.C.Bellucci, L.Bruche, G.Colombo, L.Malpezzi, S.Mazzini, S.V.Meille, M.Meli, C.R.de Arellano, M.Zanda|2003|Chem.-Eur.J.|9|4510|doi:10.1002/chem.200304881
CCDC 204503: Experimental Crystal Structure Determination
2004
Related Article: A.Volonterio, S.Bellosta, F.Bravin, M.C.Bellucci, L.Bruche, G.Colombo, L.Malpezzi, S.Mazzini, S.V.Meille, M.Meli, C.R.de Arellano, M.Zanda|2003|Chem.-Eur.J.|9|4510|doi:10.1002/chem.200304881