Search results for "TYR"

Antineoplastic Drug-Induced Cardiotoxicity: A Redox Perspective

2018

Antineoplastic drugs can be associated with several side effects, including cardiovascular toxicity (CTX). Biochemical studies have identified multiple mechanisms of CTX. Chemoterapeutic agents can alter redox homeostasis by increasing the production of reactive oxygen species (ROS) and reactive nitrogen species RNS. Cellular sources of ROS/RNS are cardiomyocytes, endothelial cells, stromal and inflammatory cells in the heart. Mitochondria, peroxisomes and other subcellular components are central hubs that control redox homeostasis. Mitochondria are central targets for antineoplastic drug-induced CTX. Understanding the mechanisms of CTX is fundamental for effective cardioprotection, without…

Interplay of three G‑quadruplex units in the KIT promoter

2019

The proto-oncogene KIT encodes for a tyrosine kinase receptor, which is a clinically validated target for treating gastrointestinal stromal tumors. The KIT promoter contains a G-rich domain within a relatively long sequence potentially able to form three adjacent G-quadruplex (G4) units, namely, K2, SP, and K1. These G4 domains have been studied mainly as single quadruplex units derived from short truncated sequences and are currently considered promising targets for anticancer drugs, alternatively to the encoded protein. Nevertheless, the information reported so far does not contemplate the interplay between those neighboring G4s in the context of the whole promoter, possibly thwarting dru…

Study of the role of “gatekeeper” mutations V654A and T670I of c-kit kinase in the interaction with inhibitors by means mixed molecular dynamics/dock…

2011

The over-expression of c-kit proto-oncogene has been reported in hematopoietic cells, small cell lung cancer, and gastrointestinal stromal tumors. The clinical importance of c-kit expression in tumors focused the research towards inhibitors of this tyrosine kinase. Imatinib (Gleevec®) was the first compound used in therapy, but mutations on c-kit led to reduced effectiveness or ineffectiveness of this treatment. Other compounds are likely to be effective against mutants, such as Sunitinib (Sutent®), but the need for new and most effective inhibitors against mutants is still critical. We report mixed Molecular Dynamics/Docking study with the aim to unveil the molecular mechanism involved in …

How Does Tyrosinase Work? Recent Insights from Model Chemistry and Structural Biology

2000

ChemInform Abstract: How Does Tyrosinase Work? Recent Insights from Model Chemistry and Structural Biology

2010

Continuous spin fractionation and characterization by size-exclusion chromatography for styrene-butadiene block copolymers.

2005

Abstract Linear and star-shaped styrene–butadiene block copolymers synthesized by anionic polymerization of butadiene and styrene were fractionated by applying a newly developed large-scale fractionation technique, named continuous spin fractionation (CSF). Their molecular weight and polydispersity index ( d  =  M w / M n ) were measured with size-exclusion chromatography and static light scattering. For the linear triblock copolymer a fractionation via temperature variation turned out to be better suited than the usual isothermal procedure. The star-shaped polymer with the d value of 1.33 was fractionated in two CSF steps to get the targeted sample, which has a considerably more uniform st…

Poly(N-isopropylacrylamide)-Modified Styrene-Butadiene Rubber as Thermoresponsive Material

2013

Observing or participating in regime change? Kyrgyz perspectives on the role of international election observation missions in 2005

2006

- This report offers an in-dept analysis of the role of international election observation missions in during the political upheavals in Kyrgyzstan in 2005. It presents the work of three leading, young academics from Kyrgyzstan. The report forms part of the ‘NUPI Network for Election Observation and Exchange’. This is project that is supported by the Norwegian Ministry of Foreign Affairs. The starting point for the assessments presented here is the realisation that international election observer missions played a central part in the events that eventually lead to the toppling of President Askar Akaev’s administration in march 2005. Kyrgyzstan is also a case that highlights the immense chal…

The battle for Azerbaijan : Azeri Perspectives on the Observation of the 2005 Parliamentary Elections and the Post-Election Period

2006

- This report seeks to highlight the role of international observer missions of the 9 November 2005 parliamentary election in Azerbaijan. It also presents in-depth assessments of the pre- and post-election situation in the country. The six articles that are presented in the volume have been produced by leading scholars or development practitioners in Azerbaijan. The report forms part of the ‘Network for Election Observation and Exchange’. This is project that is supported by the Norwegian Ministry of Foreign Affairs.

GHB related acids are useful in routine casework of suspected GHB intoxication cases

2021

Abstract GHB related acids (3,4-dihydroxy butyric acid, 2,4-dihydroxy butyric acid and glycolic acid) are produced through oxidative GHB metabolism. These analytes could be potential biomarkers to ensure the diagnosis of a GHB intoxication and even prolong the detection window. Within this study, forensic routine cases were measured to consider the potential of additional gas chromatographic mass spectrometric analysis on these acids. 17 GHB positive real cases (10 serum samples and 7 urine samples) and 40 cases with suspicion of drugging in DFC cases and negative GHB results (21 serum samples and 19 urine samples) were evaluated. Increased GHB related acid concentrations were detected in a…