Search results for "TYR"
showing 10 items of 2017 documents
Freezing without surrounding cryomedium preserves the endothelium and its function in human internal mammary arteries
2005
Abstract Purpose Cryopreserved human blood vessels may become important tools in bypass surgery. Optimal cryopreservation of an arterial graft should, therefore, preserve both histological and physiological characteristics of smooth muscle and endothelium comparable to the unfrozen artery. Methods Rings from human internal mammary arteries (IMA) were investigated in vitro either unfrozen or after immersion into a cryomedium (RPMI 1640 containing 1.8 M Me2SO and 0.1 M sucrose) and cryostorage with and without surrounding medium. Results In unfrozen IMA, neither contractile responses to noradrenaline (NA) nor endothelium-dependent relaxant responses to acetylcholine (ACH) was modified after e…
Synthesis, Optical and Electrical Properties of Oligo(phenylenevinylene)s Substituted with Electron-Accepting Sulfonyl Groups
2010
Oligo(phenylenevinylene)s (OPV) composed of five rings and electron donating or withdrawing sulfonyl substituents on the central and lateral rings have been investigated. Two strategies were used for the syntheses of the C2-symmetrical OPVs both include PO-activated olefinations as central steps. Six flexible side chains guarantee good solubility in toluene or dichloromethane. In solution and in films stabilised by polystyrene (60%), the chromophores are strongly fluorescent, with emissions in the violet-blue domain from solutions and in the green to orange region from solid films. The redox potentials, determined by cyclic voltammetry, and the optical properties are strongly depending on t…
Catalytic and anticancer activities of sawhorse-type diruthenium tetracarbonyl complexes derived from fluorinated fatty acids
2013
The reaction of fluorinated fatty acids, perfluorobutyric acid (C3F7CO2H), and perfluorododecanoic acid (C11F23CO2H), with dodecacarbonyltriruthenium (Ru3(CO)12) under reflux in tetrahydrofuran, followed by addition of two-electron donors (L) such as pyridine, 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane, or triphenylphosphine, gives stable diruthenium complexes Ru2(CO)4(μ2-η2-O2CC3F7)2(L)2 (1a, L = C5H5N; 1b, L = PTA; 1c, L = PPh3) and Ru2(CO)4(μ2-η2-O2CC11F23)2(L)2 (2a, L = C5H5N; 2b, L = PTA; 2c, L = PPh3). The catalytic activity of the complexes for hydrogenation of styrene under supercritical carbon dioxide has been assessed and compared to the analogous triphenylphosphine complexes w…
Electrochemical impedance spectroscopy of polyelectrolyte multilayer modified gold electrodes: influence of supporting electrolyte and temperature.
2005
Electrochemical impedance spectroscopy and cyclic voltammetry are employed to characterize poly(styrenesulfonate)/poly(allylamine hydrochloride) multilayers assembled onto cysteamine-modified gold surfaces. The influence of the supporting electrolyte and temperature on the impedance response is studied because of both its practical interest and the need to test further the capillary membrane model recently developed by Barreira et al. [J. Phys. Chem. B 2004, 108, 17973]. The results obtained are interpreted quite satisfactorily in terms of this model, thus providing additional support to its usefulness for the description of ionic transport through polyelectrolyte multilayers. It is observe…
Temperature dependence of surface reorganization characteristics of amphiphilic block copolymer in air and in water studied by scanning force microsc…
2015
We have investigated the surface reorganization characteristics of a novel amphiphilic diblock copolymer, poly(acetic acid-2-(2-(4-vinyl-phenoxy)-ethoxy)-ethylester)-block-polystyrene (PAEES-b-PS), in response to varying interfaces from air to water and vice-versa at various temperatures. The surface reorganization characteristics of the block copolymer films was monitored by scanning force microscopy, in order to delineate the kinetically controlled morphological process of surface reorganization of a diblock copolymer, with a particular emphasis on the phase contrast signal which allowed the determination of local composition patterns of PAEES-b-PS at the surface. Upon heating a water-an…
Sustainable Mobility in Park Areas: The Potential Offered by Guided Transport Systems
2012
The project choices to design and manage a transport infrastructure system are extremely hard in thinly populated areas like, for instance, protected areas and mostly parks. In actual fact, the need for promotion and development of these areas, often characterized by large surfaces, contrasts with the necessity to preserve their inestimable natural value. The transportation demand in extremely sensible environmental contexts can be satisfied by providing incentives to use reduced-impact means of transport, regulating adequately the vehicle traffic flow and promoting the intermodality between private and public transport systems. Apart from performing their own traditional functions, these s…
Filamiinin ja pernan tyrosiinikinaasin sitoutuminen sekä vuorovaikutuksen merkitys verihiutaleiden signaloinnissa
2013
Hyytymän muodostuminen tapahtuu verisuoneen kohdistuneen vaurion seurauksena verenvuodon tyrehdyttämiseksi. Hyytymä voi muodostua myös verisuonen pinnalle silloinkin kun verenvuotoa ei esiinny. Irrotessaan verenvuodon mukaan hyytymä voi olla hengenvaarallinen. Erilaiset hyytymän muodostamat veritulpat ovat merkittävä kuolinsyy vuosittain. Verihiutaleet ovat keskeinen tekijä tässä tapahtumassa. Niiden aktivaatio tapahtuu kalvoreseptoreiden ja solun sisäisen signaloinnin monimutkaisesta vuorovaikutuksesta. Tämän tutkimuksen kohteina ovat pernan tyrosiinikinaasi ja filamiini A, joiden välinen vuorovaikutus on tärkeää verihiutaleiden toiminnalle. Verihiutaleet, joissa tämä vuorovaikutus on häir…
Vulnerability of peripheral catecholaminergic neurons to MPTP is not regulated by alpha-synuclein.
2010
Although generally considered a prototypical movement disorder, Parkinson's disease is commonly associated with a broad-spectrum of non-motor symptoms, including autonomic dysfunctions caused by significant alterations in catecholaminergic neurons of the peripheral sympathetic nervous system. Here we present evidence that alpha-synuclein is highly expressed by sympathetic ganglion neurons throughout embryonic and postnatal life and that it is found in tyrosine hydroxylase-positive sympathetic fibers innervating the heart of adult mice. However, mice deficient in alpha-synuclein do not exhibit any apparent alterations in sympathetic development. Sympathetic neurons isolated from mouse embryo…
BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter…
2003
Spontaneous neural activity is a basic property of the developing brain,which regulates key developmental processes, including migration, neural differentiation and formation and refinement of connections. The mechanisms regulating spontaneous activity are not known. By using transgenic embryos that overexpress BDNF under the control of the nestin promoter, we show here that BDNF controls the emergence and robustness of spontaneous activity in embryonic hippocampal slices. Further, BDNF dramatically increases spontaneous co-active network activity, which is believed to synchronize gene expression and synaptogenesis in vast numbers of neurons. In fact, BDNF raises the spontaneous activity of…
Palermo e Santa Lucia siracusana
2014
Nella Sicilia paleocristiana, il culto della martire dioclezianea Loukìa conosce una notevole fortuna nei primi secoli del Cristianesimo, tanto da varcare i confini dell’Isola e da estendersi nel Mediterraneo occidentale e orientale; molto si deve, in questo senso, all’opera pastorale dei pontefici, sin dalla fine del secolo IV. Anche Palermo partecipò della promozione del culto della martire, come attesta la fondazione gregoriana di un cenobio latino dedicato ai santi Agata e Massimo in Lucuscanum; è ben nota, infatti, la connessione tra le due sante Lucia e Agata, testimoniata non solo dai ben noti luoghi dei testi agiografici, ma anche dalle innovazioni nella liturgia introdotte dal papa…