Search results for "Tact"
showing 10 items of 1313 documents
Full Sliding “Adhesive-Like” Contact of V-Belts
2002
Abstract Analysis of power transmission in a belt drive consisting of e. g. two pulleys might be treated as a boundary value problem. Tight side tension FT, slack side tension FS and the wrap angle α are the three natural boundary conditions. In the literature, theories are developed where seating and unseating as well as the power transmitting part of the contact are considered. The solutions presented so far don’t fulfil the boundary conditions properly, since a certain tension ratio FT/FS is associated with a certain contact angle and not an a priori specified one. It appears that a new type of full sliding solution must be introduced to handle the boundary condition problem. During part…
Study of new joining technique: flat clinching
2007
In this paper a development of clinching, called flat clinching, is presented. After a press clinching process, the joined sheets have been deformed by a punch with a lower diameter against a flat die. In this way a new configuration is created with a geometry that has no discontinuity on the external surface (bottom). A new procedure has also been tested: the second step is perfomed by pressing the joint between two flat dies. This second case has revealed itself to be very effective.Tensile tests have been done to compare the joints strength among the various joining techniques. Moreover some joints have been cut to analyse the changing of the contact line shape and how its characteristic…
Comparing the dynamic performance of wastewater treatment systems: A metafrontier Malmquist productivity index approach
2015
The assessment of productivity change of wastewater treatment plants (WWTPs) is essential to improve the performance over time of the facilities evaluated. This study assessed and compared the productivity growth of WWTPs operating with non-homogeneous technologies. The metafrontier Malmquist productivity index (MMPI) was computed for a sample of 99 WWTPs encompassing 4 alternative technologies: activated sludge (AS), aerated lagoon (AL), trickling filter (TF) and rotating biological contactor (BD). The results indicated that, on average, WWTPs with AS and BD exhibited better performance over time than WWTPs with AL and TF. The MMPI indicates that, over the period 2007-2009, the productivit…
Ferroptosis Meets Cell–Cell Contacts
2021
Ferroptosis is a regulated form of cell death characterized by iron dependency and increased lipid peroxidation. Initially assumed to be selectively induced in tumour cells, there is increasing evidence that ferroptosis plays an important role in pathophysiology and numerous cell types and tissues. Deregulated ferroptosis has been linked to human diseases, such as neurodegenerative diseases, cardiovascular disorders, and cancer. Along these lines, ferroptosis is a promising pathway to overcoming therapy resistance of cancer cells. It is therefore of utmost importance to understand the cellular signalling pathways and the molecular mechanisms underlying ferroptosis regulation, including cont…
Involvement of NO in contact hypersensitivity.
1998
The NO synthases (NOS) generate NO from L-arginine. High concentrations of NO have been shown to be responsible for tissue injury and cell death, while low concentrations of NO induce vasodilatation and other signaling effects. We have investigated the involvement of NO in contact hypersensitivity (CHS) reactions. CHS induced by treatment of BALB/c mice with the contact allergen 2,4-dinitrofluorobenzene (DNFB) was significantly reduced by the NOS inhibitor N-methyl-L-arginine (L-NMA), but not by the stereoisomer D-NMA, as shown by reduced ear swelling responses and evaluation of ear tissue sections. The CHS response was also reduced by aminoguanidine, which is known to preferentially inhibi…
Proximal contact alterations between implant-supported restorations and adjacent teeth in the posterior region: A 3-month prospective study
2021
Background Interproximal contact loss (ICL) is a multifactorial implant complication. The aims of this prospective clinical study were to evaluate proximal contact alterations between implant-supported fixed prostheses (IFPs) and adjacent teeth and to identify potential contributing factors. Material and Methods This study was conducted from April to September 2019 at the Department of Prosthodontics. Forty-three patients (23 females and 20 males, age range 31-70) treated with 43 posterior IFPs were recruited for this study. All proximal contacts (64) were checked visually and radiographically. Proximal contact tightness (PCT) was clinically evaluated using dental floss and measured during …
Template-Directed Protein Folding into a Metastable State of Increased Activity
1995
The principal objective of this work was to distinguish between kinetic and thermodynamic reaction control in protein folding. The deleterious effects of a specific mutation on spontaneous refolding competence were analyzed for this purpose. A Bowman-Birk-type proteinase inhibitor of trypsin and chymotrypsin was selected as a double-headed model protein to facilitate the detection of functional irregularities by the use of functional assays. The parent protein spontaneously folds into a single, fully active and thermodynamically stable state in a redox buffer after reduction/denaturation. By contrast, the properties of a P'1Ser--Pro variant in the trypsin-reactive subdomain differ before an…
Proteomics of CaCO3 biomineral-associated proteins: how to properly address their analysis.
2013
8 pages; International audience; In a recent editorial (Proc. Natl. Acad. Sci., 2013 110, E2144-E2146) and elsewhere, questions have been raised regarding the experimental practices in relation to the proteomic analysis of organic matrices associated to the biomineralized CaCO3 skeletons of metazoans such as molluscan shells and coral skeletons. Indeed, although the use of new high sensitivity MS technology potentially allows to identify a greater number of proteins, it is also equally (or even more) sensitive to contamination of residual proteins from soft tissues, which are in close contact with the biomineral. Based on our own past and present experimental know-how-observations that are …
Tears as a source of biomarkers for ocular and systemic diseases
2013
The main focus in clinical proteomics is the discovery of new protein or peptide biomarkers which are correlated with a certain disease. Tear proteins have been investigated extensively in the past and distinct relations between the levels of certain tear proteins to different disorders have been demonstrated. In this review we attempt to summarize proteomic technologies for biomarker identification in tears and some disease related biomarkers in tear fluids that were discovered through different proteomic techniques in different conditions like dry eye, Sjogren's syndrome, contact lens wearers, glaucoma, diabetic retinopathy or cancer. Proteomic analysis of tear fluid has proven to be a pr…
Proteomics of Galápagos Marine Iguanas Links Function of Femoral Gland Proteins to the Immune System
2020
Femoral glands secrete a wax-like substance on the inner side of lizard hind legs, which is thought to function as a mode of chemical communication. Though the minor volatile fraction is well studied, the major protein fraction remains enigmatic. Here, we use proteomics to analyze proteins in femoral gland secretions of the Galápagos marine iguana. Although we found no evidence for proteins and peptides involved in chemical communication, we found several immune-regulatory proteins which also demonstrate anti-microbial functions. Accordingly, we show that femoral gland proteins and peptides function as a barrier against microbial infection and may prevent the rapid degradation of volatile s…