Search results for "Tailored"

Liquid biopsy: another tool towards tailored therapy in colorectal cancer.

2017

2018

There are two important gaps of knowledge in depression treatment, namely the lack of biomarkers predicting response to antidepressants and the limited knowledge of the molecular mechanisms underlying clinical improvement. However, individually tailored treatment strategies and individualized prescription are greatly needed given the huge socio-economic burden of depression, the latency until clinical improvement can be observed and the response variability to a particular compound. Still, individual patient-level antidepressant treatment outcomes are highly unpredictable. In contrast to other therapeutic areas and despite tremendous efforts during the past years, the genomics era so far ha…

Poor Esophageal Motility: A Tailored Approach?

2014

New onset dysphagia following antireflux surgery is among the most undesirable side effects of an otherwise excellent therapy. While its cause is multifactorial, insufficient circular muscle strength of the esophageal body, not powerful enough to force the bolus through the distal neo-high pressure zone, can be a component of the pathophysiology. The relative merits of “tailoring” the degree of fundoplication based upon esophageal body motility and/or other clinical features have been debated for decades. Herein we discuss the rationale for a tailored approach, its pros and cons and review data published to date available to guide the clinician in individual patient decision-making.

Proposed use of a conversational agent for patient empowerment

2021

Empowerment is a process through which people acquire the necessary knowledge and self-awareness to understand their conditions and treatment options, make informed choices and self-manage their health conditions in daily life, in collaboration with medical professionals. Conversational Agents in healthcare could play an important role in the process of empowering a person but, so far, they have been seldom been used for this purpose. This paper presents the basic principles and preliminary implementation of a conversational health agent for patient empowerment. It dialogues with the user in a "natural" way, collects health data from heterogeneous sources and provides the user wit…

Executive functions rehabilitation proposal: A tailored intervention

2018

Executive functions (EFs) are cognitive processes that allow the development of intentional behaviors e requiring the ability to formulate goals and objectives, capacity for initiative, to anticipate the consequences of actions, to organize behavior and monitor it and adapt it based on the context. Patients with EFs deficiencies exhibit specific disorders of planning, regulation and correction intentional conduct and cognitive activity, while they have no problem in the execution of usual action sequences.

Effects of comprehensive geriatric assessment and targeted intervention on mobility in persons aged 75 years and over: a randomized controlled trial

2011

Objective: To assess the effect of a comprehensive geriatric assessment and individually tailored intervention on mobility in older people. In addition, the effectiveness of the geriatric intervention was evaluated among a subgroup of persons with musculoskeletal pain. Design: Three-year geriatric development project with randomized assignment to intervention and control group. Setting: Research centre, community and assisted living facilities. Participants: Seven hundred and eighty-one Finnish persons aged 75–98 years were assigned to an intervention ( n = 404) or control ( n = 377) group. Intervention: A comprehensive geriatric assessment with a multifactorial intervention lasting two ye…

Friction stir welding of tailored joints for industrial applications

2009

Friction stir welding (FSW) is an energy efficient and environmentally "friendly" (no fumes, noise, or sparks) welding process, during which the workpieces are welded together in a solid-state joining process at a temperature below the melting point of the workpiece material under a combination of extruding and forging. Since its invention in 1991 by TWI, such process has been reaching a continuously increasing popularity among aerospace, automotive and shipbuilding industries due its capability to weld unweldable or difficult-to-weld light alloys in different joint morphologies. In this paper a wide experimental campaign is carried out in order to obtain T and lap joints characterized by d…

Active Travel and Mild Cognitive Impairment among Older Adults from Low- and Middle-Income Countries

2021

Active travel may be an easily achievable form of physical activity for older people especially in low- and middle-income countries (LMICs), but there are currently no studies on how this form of physical activity is associated with a preclinical state of dementia known as mild cognitive impairment (MCI). Therefore, we aimed to investigate the association between active travel and MCI among adults aged ≥50 years from six LMICs. Cross-sectional, community-based data from the World Health Organization’s Study on Global Ageing and Adult Health were analyzed. The definition of MCI was based on the National Institute on Ageing-Alzheimer’s Association criteria. Active travel (minutes/week) was as…

Tools to identify nutritional risk for older people in the home

2012

Author's version of an article in the journal: British Journal of Community Nursing. Community nurses are in an ideal position to identify older home-dwelling people at nutritional risk and thereby to prevent undernutrition. The aim of this paper is to present some nutritional screening instruments for older home-dwelling people and to discuss nutritional issues of importance for community nurses in order to assess nutritional risk and prevent undernutrition. The screening instruments Nutritional Form For the Elderly (NUFFE) and Mini Nutritional Assessment (MNA) are especially developed for screening older people. The Malnutrition Universal Screening Tool (MUST) is recommended for screening…

Trends in Radical Prostatectomy Risk Group Distribution in a European Multicenter Analysis of 28 572 Patients: Towards Tailored Treatment

2019

Background: Active surveillance (AS) has been increasingly proposed as the preferential initial management strategy for low-risk prostate cancer (PC), while in high-risk PC the indication for surgery has widened. Objective: To evaluate the development of risk group distribution of patients undergoing radical prostatectomy (RP). Design, setting, and participants: Retrospective database review of combined RP databases (2000-2015) of four large European centers (Créteil, Paris; San Rafaele, Milan; Martini Klinik, Hamburg; NKI, AvL, Amsterdam). Outcome measurements and statistical analysis: Clinical and pathological characteristics per year of surgery. Eligibility for AS was defined according …