Search results for "Tegu"
showing 8 items of 768 documents
MicroRNAs in Extracellular Vesicles in Sweat Change in Response to Endurance Exercise
2020
Background: To date, microRNAs (miRs) carried in extracellular vesicles (EVs) in response to exercise have been studied in blood but not in non-invasively collectable body fluids. In the present study, we examined whether six exercise–responsive miRs, miRs-21, -26, -126, -146, -221, and -222, respond to acute endurance exercise stimuli of different intensities in sweat. Methods: We investigated the response of miRs isolated from sweat and serum EVs to three endurance exercise protocols: (1) maximal aerobic capacity (VO2max), (2) anaerobic threshold (AnaT), and (3) aerobic threshold (AerT) tests. Sauna bathing was used as a control test to induce sweating through increased body temperature i…
Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing
2020
Adipose tissue derived stem cells (ADSCs) are mesenchymal stem cells identified within subcutaneous tissue at the base of the hair follicle (dermal papilla cells), in the dermal sheets (dermal sheet cells), in interfollicular dermis, and in the hypodermis tissue. These cells are expected to play a major role in regulating skin regeneration and aging-associated morphologic disgraces and structural deficits. ADSCs are known to proliferate and differentiate into skin cells to repair damaged or dead cells, but also act by an autocrine and paracrine pathway to activate cell regeneration and the healing process. During wound healing, ADSCs have a great ability in migration to be recruited rapidly…
Topic tacrolimus, alternative treatment for oral erosive lichen planus resistant to steroids : a case report
2006
The lichen planus is a mucocutaneous disease with unknown etiology and auto-immune pathogenia. There have been three variants of lichen planus: the reticular, the plaque-like and the atrophic-erosive lesions. It?s a chronic disease with acute relapses that generally affects more frecuently to women from the fourties. The diagnostic is based on the clinic identification of the lesions joined with the histopathologic study (basal cells hidropic degeneration, linfoplasmocitic infiltration and absence of displasy signs). The great number of therapeutic options are explained for its high prevalency (0.5-2%), its recurrence and its risk for malignant transformation. We present a case of oral eros…
A boy with oral hair: Case report
2007
In personal communication we have never seen or heard of hair being detected in the oral cavity. Even Julia Pastrana, the famous ?Bearded Lady? of the 1800?s, had no record of oral hair, although her entire body was covered with hair. Extensive records of her oral condition, including plaster models of her teeth have been preserved in the Odontological Museum of the Royal College of Surgeons in London city. She suffered from excessive gingival hyperplasia, but apparently no hair existed within the mouth. Some rodents have oral hair as a normal occurrence, but the condition is apparently limited in the animal kingdom. A case of hair occurring naturally in the mouth has been reported only twi…
Oral lichen planus and oral lichenoid lesions; a critical appraisal with emphasis on the diagnostic aspects
2009
Oral lichen planus (OLP) has a prevalence of approximately 1%. The etiopathogenesis is poorly understood. The annual malignant transformation is less than 0.5%. There are no effective means to either predict or to prevent such event. Oral lesions may occur that to some extent look like lichen planus but lacking the characteristic features of OLP, or that are indistinguishable from OLP clinically but having a distinct cause, e.g. amalgam restoration associated. Such lesions are referred to as oral lichenoid lesions (OLLs). The management of OLP and the various OLLs may be different. Therefore, accurate diagnosis should be aimed at.
Lichen Planus: A Muco-Cutaneous, Nails and Scalp Disorder – Cases Report
2019
Abstract Lichen planus is an autoimmune, itching disorder that involves T lymphocytes, which may interest the skin, mucous membranes and exoskeletons. The presence of lichen manifestations both at the skin, mucous membranes and at the level of the skin attachments (hair and nails) is rarely mentioned in the literature. Although lichen planus may have a self-limiting evolution, early treatment is important in shortening the evolution of the disease and in controlling the symptoms. The therapeutic effects of retinoids (immunomodulatory, anti-inflammatory, anti-proliferative effects) make them an appropriate choice in the treatment of lichen with (cutaneous-mucosal, nail and planopilaris lesio…
Development of polypeptide-based therapeutics for topical delivery
2019
Topical administration represents the main route to attain local therapeutic activity of bioactive agents in several organs, such as the skin or the heart by means of devices that enhance drug transport through the endothelium acting as a reservoir. The complex structure of the skin protects the human body against potentially harmful external agents; however, this protective mechanism inhibits the penetration of topically administering bioactive agents employed for the treatment of skin diseases. Unfortunately, many of the topical drugs currently used or under evaluation in clinical trials lack the appropriate physico-chemical characteristics required for delivery through the skin. However,…
Demonstrating measure-correlate-predict algorithms for estimation of wind resources in central Finland
2010
In this study, measure-correlate-predict (MCP) algorithms - Simple Linear Regression and Variance Ratio Methods - for predicting wind speed were studied. The MCP algorithms were successfully used to predict missing wind speeds at two sites in Jyväskylä and Viitasaari, respectively. These two algorithms used data from one of the site to predict missing wind speed data at the other site. The results obtained using the MCP methods were compared using metrics that showed the characteristics of the predicted data to be unbiased compared to measured data. From the data of this study, we also evaluated wind power density at both sites which categorized the local wind resources as poor since the de…