Search results for "Teratology"

Piante e loro anomalie vegetative. schede documentarie. 1-26

2010

Schede 1-11. In: RAIMONDO F.M. & SCHICCHI R. Piante e loro anomalie vegetative: schede documentarie. 1-26.

2010

Long-Term Administration of High Dose Vitamin A to Rats Does Not Cause Fetal Malformations: Macroscopic, Skeletal and Physicochemical Finds

1996

A rat model was used to investigate whether high oral doses of vitamin A lead to fetal malformations and to what extent retinyl esters (RES) are transferred from the mother to the fetuses. Retinol and RES concentrations in plasma behave similarly in rats and humans. When high concentrations of vitamin A are administered, plasma retinol concentrations remain relatively constant, whereas plasma RES increased in parallel with the dose. To achieve an elevation from approximately 150 to > 1525 nmol x L(-1) in the experimental group before mating, female Ibm: RORO (spf) rats were fed a maintenance diet enriched with 15.2 x 10(3) retinol equivalents (RE) x kg(-1) at the start and increased stepwis…

Myo-inositol counteracts the vegetalizing effect of lithium on P.lividus embryos

1992

Abstract The vegetalizing effect of LiCl on sea urchins embryos can be counteracted by the addition of myo-inositol. This observation is discussed in connection with similar results recently reported for amphibian embryos.

Serial examination of 20,248 newborn fetuses and infants: Correlations between drug exposure and major malformations

1996

Maternal medication during the first trimester of pregnancy has been discussed as a risk factor for development of birth defects. The correlation between maternal drug use and major malformations was investigated in a population-based case-control study in Mainz. Over a period of 5 years (1990–1994), 20,248 livebirths, stillbirths, and abortions underwent physical and sonographic examination, and anamnestic data were collected. A total of 1,472 births with congenital anomalies (cases) and 9,682 births without major and minor malformations (controls) were analyzed. We distinguished between 30 different drug categories, which were divided into medication taken continuously (before and during …

Occupational exposure to pesticides and congenital malformations: A review of mechanisms, methods, and results

1998

Pesticides are chemicals that are widely used all over the world. Human beings can be exposed through environmental contamination and/or occupational use of pesticides. Although there is substantial information on the acute toxicity of many of these chemicals, available knowledge on delayed effects is much more limited. This paper reviews epidemiological studies on occupational exposure to pesticides, mainly in agricultural workers, and risk of congenital malformations. The discussion includes postulated mechanisms for birth defects from paternal or maternal exposure, a detailed review of method of the studies carried out so far on the relationship between occupational exposure to pesticide…

«Fetal monstrosities». A comparision of evidenze in Sicily in modern age

2013

In Sicily reflections on monsters and on ‘generative stumbles’ first appear in a treaty of the second half of the sixteenth century, containing one of the first medical-physiological descriptions of two-headed births and written in the verncular by the famous physiologist and anatomist Giovanni Filippo Ingrassia. It is a work which can be attributed to the season of excitement characterized, in the period after 1550, by an explosion of interest in teratological codification, driven by a wider taxonomic interest in the living and the inanimate, but it also contains some original features that make it a model and example of the contemporary state of the art of legal medicine, of which Ingrass…