Search results for "Terbinafine"

showing 3 items of 3 documents

German randomized double-blind multicentre comparison of terbinafine and itraconazole for the treatment of toenail tinea infection

1996

Summary One–hundred and ninety–five patients with toenail tinea unguium were recruited to a multicentre double–blind clinical trial. Patients were given 250mg terbinafine or 200 mg itraconazole daily for 12 weeks, with follow–up for a further 40 weeks. At the end of the study, mycological cure rates were 81% (70/86 assessed) for terbinafine and 63% (53/84 assessed) for itraconazole (two–tailed, P < 0·05). The length of unaffected nail was 9·44 mm in the terbinafine group and 7·85 mm in the itraconazole group (two–tailed, P < 0·05). Patient self–assessment also favoured terbinafine, with 65% evaluating it as good to very good, compared with 58% for itraconazole. Before treatment the terbinaf…

AdultMalemedicine.medical_specialtyAntifungal AgentsItraconazoleDermatologyNaphthalenesDouble blindDouble-Blind MethodOnychomycosismedicineHumansTerbinafineAgedbusiness.industryTinea PedisTinea unguiumMiddle AgedDermatologyClinical trialmedicine.anatomical_structurePatient SatisfactionNail (anatomy)TerbinafineFemaleItraconazoleTinea InfectionbusinessFollow-Up Studiesmedicine.drugBritish Journal of Dermatology
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Characterization of the antimicrobial susceptibility of fungi responsible for onychomycosis in Spain

2010

Due to the increase of choices relative to antifungals, there is a need to improve the standardization of in vitro methods used to determine the antifungal susceptibility of fungal pathogens. Our study evaluated the in vitro susceptibility of filamentous fungi isolated from patients with toenail onychomycosis against itraconazole, ciclopirox, eberconazole, fluconazole and terbinafine. The minimum inhibitory concentration (MIC) of these antifungal agents was determined with 100 isolates, including dermatophytes (70 strains) and non-dermatophyte molds (30 strains). The susceptibility of fungal isolates was measured by using a technique modified for dermatophytes (0.5 × 10(3)-0.5 × 10(4) conid…

Antifungal AgentsCiclopiroxItraconazoleFungiMicrobial Sensitivity TestsGeneral MedicineBiologyAntimicrobialbiology.organism_classificationMicrobiologyMinimum inhibitory concentrationInfectious DiseasesSpainOnychomycosismedicineHumansTerbinafineArthrodermataceaeEberconazoleFluconazolemedicine.drugMedical Mycology
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&lt;tocheading&gt;Original Article&lt;/tocheading&gt;

1999

In this double-blind clinical trial 429 patients (217 terbinafine and 212 clotrimazole) were randomized to receive twice daily terbinafine 1% topical solution for 1 week followed by a vehicle application for 3 weeks, or 1% clotrimazole solution for 4 weeks. Patients were evaluated clinically and mycologically at baseline and then at weeks one, two, four (end of treatment), and eight (end of follow-up). To be evaluable the patient needed to have a positive culture for a dermatophyte and positive KOH microscopy and a clinical diagnosis of tinea pedis (interdigital type) at baseline. Effective treatment of tinea pedis was recorded in 181 of 217 (83%) of patients treated for 1 week with terbina…

medicine.medical_specialtybusiness.industryClotrimazoleDermatologyGeneral Medicinemedicine.disease_causemedicine.diseaseDermatologylaw.inventionClinical trialInfectious DiseasesRandomized controlled trialTolerabilitylawmedicineDermatophyteTerbinafinebusinessAdverse effectMycosismedicine.drugMycoses
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