Search results for "Terminal"

Non-invasive ventilation in amyotrophic lateral sclerosis.

2006

Vitamin B12 Deficiency in Children after Continent Urinary Diversion by Mainz Pouch Technique

2010

Purpose MAINZ pouch I urinary diversion provides a high-capacity, low-pressure reservoir. The use of terminal ileum can cause a decrease of vitamin B12 levels. Symptoms caused by vitamin B12 deficiency are rare, but some are irreversible, therefore annual check-ups are recommended. In this study the vitamin B12 levels in the above patients were analyzed in retrospect. Material and Methods The ileocecal segment was used for urinary tract reconstruction in > 80 children ≤17 years of age. B12 levels were determined at various time points within up to 21 years after surgery in 63 patients (8 with ileocecal bladder substitution, 55 continent cutaneous diversion). B12 values below 200pg/ml were c…

Bone Turnover Markers and Potential Correlation with Outcomes in Patients with Genitourinary Cancer (Renal and Bladder) and Bone Metastasis (Results …

2012

ABSTRACT Background Levels of bone turnover markers (BTM) might be correlated with outcome in terms of skeletal related events (SRE), disease progression and death. The aim of the study was to determine the possible correlation between BTM, disease progression, SREs and death in patients with genitourinary cancer and bone metastases (BM) treated with zoledronic acid (ZA). Methods Observational, prospective, multicenter study. Patients with genitourinary cancer (prostate, renal, bladder) and BM were included. BTM determined were: carboxiterminal telopeptide of type I collagen (β-CTX) and bone specific alkaline phosphatase (BALP) by ELISA (immunoenzymatic assay, IDS UK), and aminoterminal pro…

Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo.

2011

Identification of physiologically relevant substrates is still the most challenging part in protease research for understanding the biological activity of these enzymes. The zinc-dependent metalloprotease meprin β is known to be expressed in many tissues with functions in health and disease. Here, we demonstrate unique interactions between meprin β and the amyloid precursor protein (APP). Although APP is intensively studied as a ubiquitously expressed cell surface protein, which is involved in Alzheimer disease, its precise physiological role and relevance remain elusive. Based on a novel proteomics technique termed terminal amine isotopic labeling of substrates (TAILS), APP was identified …

Assessment of Cyber Security risks : A Smart Terminal Process

2023

In Finland, the connections to global maritime transportation logistics systems are an essential part of the national critical infrastructure. As a part of maritime logistics systems, the port's operations are important elements for global maritime traffic and the transportation supply chain. Digitalization of seaport services makes it possible to increase the efficiency of terminal systems in the logistic processes. At the same time, port logistic processes can notably reduce its CO2 emissions by optimizing port operations. The improvement of port processes relies very much on the development of Information and Communication Technology (ICT) and Industrial Control Systems (ICS) or Operatio…

The Deathbed Repentance in Tolstoy's "The Death of Ivan Ilych" and Conrad's "Heart of Darkness"

2022

Notes on the genus Rasilinus Mazur, 2016 (Curculionidae: Curculioninae, Eugnomini), with the description of a new species from New Caledonia

2017

New data on the genus Rasilinus (Curculioninae, Eugnomini) are provided, including the description of a new species—Rasilinus bifasciatus sp. n., from New Caledonia. Illustrations and SEM photographs of male external morphology, terminalia, and a colour habitus of the adult of the new species are provided. 

Models and algorithms for berth allocation problems in port terminals

2017

Seaports play a key role in maritime commerce and the global market economy. Goods of different kinds are carried in specialized vessels whose handling requires ad hoc port facilities. Port terminals comprise the quays, infrastructures, and services dedicated to handling the inbound and outbound cargo carried on vessels. Increasing seaborne trade and ever-greater competition between port terminals to attract more traffic have prompted new studies aimed at improving their quality of service while reducing costs. Most terminals implement operational planning to achieve more efficient usage of resources, and this poses new combinatorial optimization problems which have attracted increasing att…

Calidad de visión y satisfacción del paciente usuario de pantallas de visualización de datos tras cirugía refractiva

2007

Objetivo: Evaluar la influencia en la calidad de vida y satisfacción de los trabajadores usuarios de pantallas de visualización de datos (PVD) que se asocia a la mejora de la función visual tras queratomileusis in situ con láser excimer (LASIK). Métodos: Estudio observacional y longitudinal en una población de 96 pacientes intervenidos de cirugía refractiva con láser excimer según técnica LASIK mediante aplicación de un cuestionario construído al efecto aplicado antes y después de cirugía por un observador independiente. Resultados: Agudeza visual y refracción ocular han mejorado tras LASIK, siendo el índice de eficacia de 1.1. La sensibilidad al contraste tras cirugía mejora en todas las f…

Late Activation of Stress-activated Protein Kinases/c-Jun N-terminal Kinases Triggered by Cisplatin-induced DNA Damage in Repair-defective Cells

2011

Although stress-activated protein kinases/c-Jun N-terminal kinases (SAPK/JNK) are rapidly activated by genotoxins, the role of DNA damage in this response is not well defined. Here we show that the SEK1/MKK4-mediated dual phosphorylation of SAPK/JNK (Thr-183/Tyr-185) correlates with the level of cisplatin-DNA adducts at late times (16–24 h) after drug treatment in both human and mouse cells. Transfection of platinated plasmid DNA also caused SAPK/JNK activation. A defect in transcription-coupled nucleotide excision repair resting on a mutation in Cockayne syndrome group B protein promoted the late SAPK/JNK activation following cisplatin exposure. Signaling to SAPK/JNK was accompanied by act…