Search results for "Tertiary"

4-Methyl-N-(4-methylpyridin-2-yl)-N-(3,4,5,6-tetrahydro-2H-pyran-4-yl)pyridin-2-amine

2016

In the title compound, C17H21N3O, the pyridine rings make a dihedral angle of 84.44 (5)°. In the crystal, a C—H...N interaction forms a chain of molecules propagating along the twofold screw axis.

Development of sustainable ORC applications in the tertiary sector: a case study in the Mediterranean climate

2022

Abstract In recent decades, climate change strong advancement has led many countries, especially the most developed ones, to a greater sense of environmental responsibility. On a global, European and national level, adaptation/mitigation strategies and actions aimed at improving energy-environmental sustainability and resilience in the tertiary sectors have been increasingly intensified. In this sector, therefore, plays a fundamental role the integration/introduction of technologies able to operate an efficient conversion of energy, such as indeed Organic Rankine Cycle (ORC) plant, other than renewable energy sources, in order to reduce both energy consumption and pollutant emissions. Withi…

Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases.

2008

The receptor for advanced glycation end products (RAGE) is a 55-kDa type I membrane glycoprotein of the immunoglobulin superfamily. Ligand-induced up-regulation of RAGE is involved in various pathophysiological processes, including late diabetic complications and Alzheimer disease. Application of recombinant soluble RAGE has been shown to block RAGE-mediated pathophysiological conditions. After expression of full-length RAGE in HEK cells we identified a 48-kDa soluble RAGE form (sRAGE) in the culture medium. This variant of RAGE is smaller than a 51-kDa soluble version derived from alternative splicing. The release of sRAGE can be induced by the phorbol ester PMA and the calcium ionophore c…

Higher plants possess two different types of ATX1-like copper chaperones.

2007

Abstract Copper (Cu) chaperones constitute a family of small Cu+-binding proteins required for Cu homeostasis in eukaryotes. The ATX1 family of Cu chaperones specifically delivers Cu to heavy metal P-type ATPases. The plant Arabidopsis thaliana expresses the ATX1-like Cu chaperone CCH, which exhibits a plant-specific carboxy-terminal domain (CTD) with unique structural properties. We show that CCH homologues from other higher plants contain CTDs with structural properties similar to Arabidopsis CCH. Furthermore, we identify a new ATX1-like Cu chaperone in Arabidopsis, AtATX1, which functionally complements yeast atx1Δ and sod1Δ associated phenotypes, and localizes to the cytosol of Arabidop…

Type II keratin cDNAs from the rainbow trout: implications for keratin evolution.

2002

From a teleost fish, the rainbow trout Oncorhynchus mykiss, we have cloned and sequenced cDNAs encoding five different type II keratins. The corresponding protein spots, as separated by 2D-PAGE of trout cytoskeletal preparations, have been identified by peptide mass mapping using MALDI mass spectrometry. Three of the sequenced keratins are expressed in the epidermis (subtype IIe), and two in simple epithelia and mesenchymal cells (subtype IIs). The IIs keratins are both orthologs of human K8. This leaves unsequenced only the trace component S3 of the biochemically established trout keratin catalog. A phylogenetic tree has been constructed from a multiple alignment of the rod domains of the …

The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS

2007

Membrane fission is an essential process in membrane trafficking and other cellular functions. While many fissioning and trafficking steps are mediated by the large GTPase dynamin, some fission events are dynamin independent and involve C-terminal-binding protein-1/brefeldinA-ADP ribosylated substrate (CtBP1/BARS). To gain an insight into the molecular mechanisms of CtBP1/BARS in fission, we have studied the role of this protein in macropinocytosis, a dynamin-independent endocytic pathway that can be synchronously activated by growth factors. Here, we show that upon activation of the epidermal growth factor receptor, CtBP1/BARS is (a) translocated to the macropinocytic cup and its surroundi…

A zongora-improvizáció szerepe és széleskörű alkalmazása a barokk és jazz harmónia tanításában – egy doktori kutatás eredményei. = The role of piano …

2016

Lectio Praecursoria: The role of piano improvisation in teaching harmony, using combined materials selected from the Baroque period and jazz standard…

2016

Finnish reform of the funding and provision of special education : the views of principals and municipal education administrators

2015

This study examines the current state of special education provision and resources in Finland after the extensive reform of the government transfer system and Basic Education Act implemented in 2010–2011. Data were collected from a survey of compulsory school principals and from interviews with the highest-ranking officials in municipal education administration. The results show that participants viewed the Basic Education Act as having a more significant impact on the provision of special education than the reform of the government transfer system. Partly due to the reforms, local authorities have targeted the resources of special education differently and used resources more effectively. …

INDUSTRY - A PILLAR OF STRENGTH ECONOMIC AND SOCIAL DEVELOPMENT. ROMANIAN SEQUENCES

2012

In the last 300 years, industry was the key driver of economic development and social, political, military, cultural and spiritual, which are inconceivable without the contribution of this important sector of the economy of any country. At least in these 300 years since the first industrial revolution, industrialization took place in every country in the world along with free trade, protectionism alternation - free schimbism contributing to balancing economic and social development. Nothing is more important than industry between the four basic economic sectors (agriculture, industry, trade and transport). Recrudescence services of any kind, but also the unprecedented quaternary sector (lei…