Search results for "Testing"
showing 10 items of 1769 documents
Bayesian measures of surprise for outlier detection
2003
From a Bayesian point of view, testing whether an observation is an outlier is usually reduced to a testing problem concerning a parameter of a contaminating distribution. This requires elicitation of both (i) the contaminating distribution that generates the outlier and (ii) prior distributions on its parameters. However, very little information is typically available about how the possible outlier could have been generated. Thus easy, preliminary checks in which these assessments can often be avoided may prove useful. Several such measures of surprise are derived for outlier detection in normal models. Results are applied to several examples. Default Bayes factors, where the contaminating…
On powerful exact nonrandomized tests for the Poisson two-sample setting.
2020
In the case of two independent samples from Poisson distributions, the natural target parameter for hypothesis testing is the ratio of the two population means. The conditional tests which have been derived for this class of problems already in the 1940s are well known to be optimal in terms of power only when randomized decisions between hypotheses are admitted at the boundary of the respective rejection regions. The major objective of this contribution is to show how the approach used by Boschloo in 1970 for constructing a powerful nonrandomized version of Fisher’s exact test for hypotheses about the odds ratio between two binomial parameters can successfully be adapted for the Poisson c…
A multi-scale approach for testing and detecting peaks in time series
2020
An approach is presented that combines a statistical test for peak detection with the estimation of peak positions in time series. Motivated by empirical observations in neuronal recordings, we aim at investigating peaks of different heights and widths. We use a moving window approach to compare the differences of estimated slope coefficients of local regression models. We combine multiple windows and use the global maximum of all different processes as a test statistic. After rejection, a multiple filter algorithm combines peak positions estimated from multiple windows. Analysing neuronal activity recorded in anaesthetized mice, the procedure could identify significant differences between …
Assessing local differences between the spatio-temporal second-order structure of two point patterns occurring on the same linear network
2021
Abstract We introduce Local Indicators of Spatio-Temporal Association (LISTA) functions on linear networks and use them to build a statistical test for local second-order structure. This allows to identify differences in the spatio-temporal clustering behaviour of two point patterns, a point pattern of interest and a background one, both occurring on the same linear network. We assess the performance of the testing procedure for local second-order structure through simulation studies under a variety of scenarios that also account for different generating point processes. We show that the proposed local test is able to correctly identify the spatio-temporal difference in the local second-ord…
The Choice of Item Difficulty in Self-Adapted Testing
2000
Summary: The difficulty level choices made by examinees during a self-adapted test were studied. A positive correlation between estimate ability and difficulty choice was found. The mean difficulty level selected by the examinees increased nonlinearly as the testing session progressed. Regression analyses showed that the best predictors of difficulty choice were examinee ability, difficulty of the previous item, and score on the previous item. Four strategies for selecting difficulty levels were examined, and examinees were classified into subgroups based on the best-fitting strategy. The subgroups differed with regard to ability, pretest anxiety, number of items passed, and mean difficult…
Bioresponsive poly(amidoamine)s designed for intracellular protein delivery.
2013
Poly(amidoamine)s with bioreducible disulfide linkages in the main chain (SS-PAAs) and pH-responsive, negatively charged citraconate groups in the sidechain have been designed for effective intracellular delivery and release of proteins with a net positive charge at neutral pH. Using lysozyme as a cationic model protein these water soluble polymers efficiently self-assemble into nanocomplexes by charge attraction. At pH 5 (the endosomal pH) the amide linkages connecting the citraconate groups in the sidechains of the SS-PAAs are hydrolyzed by intramolecular catalysis, resulting in expulsion of the negative citraconate groups and formation of protonated amine groups, resulting in charge reve…
Barriers to rotation in ortho-substituted tertiary aromatic amides: Effect of chloro-substitution on resonance and distortion
2018
Planarity of the amide bond represents one of the most widely recognized properties of amides. Herein, we report a combined structural and computational study on the effect of ortho-substitution on resonance and barriers to rotation in tertiary aromatic amides. We demonstrate that ortho-chloro substitution in a class of benzamides that are important from the reactivity and medicinal chemistry perspective results in increased barriers to rotation around both the N-C(O) and C-C(O) axes. The effect of steric hindrance on structures, resonance energies, barriers to rotation, and proton affinities is discussed. The present study strongly supports the use of ortho-substitution in common benzamide…
Synthesis and structural characterisation of bulky heptaaromatic (hetero)aryl o-substituted s-aryltetrazines
2020
An expedient two-step synthesis produces in good yield polyaromatic heptacyclic (hetero)arylated o-substituted s-aryltetrazines (s-Tz) directly from diphenyl s-tetrazine. This methodology overcomes the steric limitations of classical Pinner-like syntheses encountered for o-functionalized s-Tz. A single step palladium-catalyzed N-directed C–H bond tetrahalogenation is followed by a Pd-catalyzed Suzuki (hetero)arylation that is achieved simultaneously on four sites. The single crystal X-ray diffraction structure of the resulting typical polyaromatic heptacyclic aromatic compound 3,6-bis(2,6-diphenyl)-1,2,4,5-tetrazine (3) is analyzed, together with R-functionalized peripheral phenyl derivativ…
Benzoannulated quinone-type electron acceptors: evolution of the molecular and electronic structures upon reduction
1998
Abstract The molecular and electronic structures of DCNQI and its π-extended derivatives benzo-DCNQI and DCAQI have been investigated using ab initio 6-31G ∗ calculations. The steric hindrance introduced by lateral benzoannulation determines the loss of planarity of the DCNQI moiety for DCAQI. The most stable conformation of DCAQI corresponds to a butterfly-type structure, in which the DCNQI ring adopts a boat conformation and the lateral benzene rings remain planar. This structure lies 2.75 kcal mol −1 below the fully planar conformation. MP2/6-31G ∗ calculations including full geometry optimization confirm the greater stability of the butterfly structure. The geometries of the anions and …
Prediction of Airport Pavement Moduli by Machine Learning Methodology Using Non-destructive Field Testing Data Augmentation
2022
For the purpose of the Airport Pavement Management System (APMS), in order to optimize the maintenance strategies, it is fundamental monitoring the pavement conditions’ deterioration with time. In this way, the most damaged areas can be detected and intervention can be prioritized. The conventional approach consists in performing non-destructive tests by means of a Heavy Weight Deflectometer (HWD). This equipment allows the measurement of the pavement deflections induced by a defined impact load. This is a quite expensive and time-consuming procedure, therefore, the points to be investigated are usually limited to the center points of a very large mesh grid. Starting from the measured defle…