Search results for "TetR"

Consumo de medicamentos en el embarazo y riesgo de anomalías congénitas en la Comunitat Valenciana

2017

Resumen: Antecedentes: El consumo de medicamentos durante el embarazo se ha incrementado en las últimas décadas. Objetivo: Identificar el riesgo de anomalías congénitas (AC) asociado a la utilización de medicamentos en atención ambulatoria en embarazadas residentes en la Comunitat Valenciana. Métodos: Estudio de casos-controles, considerando caso a menores de un año nacidos vivos en 2009-2010 diagnosticados de AC y residentes en la Comunitat Valenciana, obtenidos del registro poblacional de AC. Los controles se seleccionaron del Registro de Metabolopatías y la medicación prescrita y dispensada se obtuvo del módulo Gestión Integral de Prestación Farmacéutica. Se calcularon las odds ratio (OR…

Satisfacción y adherencia al tratamiento en disfunción eréctil a medio y largo plazo

2017

Resumen Introduccion El objetivo ha sido mostrar la satisfaccion y adherencia al tratamiento en disfuncion erectil (DE) a medio y largo plazo. Material y metodos Estudio descriptivo y comparativo llevado a cabo en 2 centros mediante entrevistas telefonicas a pacientes que realizaron una primera visita entre 2012 y 2014 por DE. Se realizo una anamnesis completa sobre el uso y abandono del tratamiento. En caso de uso actual se cumplimentaron los cuestionarios EDITS y GAQ, y en caso de uso pasado solo el GAQ. Para el analisis estadistico se utilizaron el test exacto de Fisher para las comparaciones de porcentajes y el test de Kruskal-Wallis para comparar medias. Resultados Doscientos cincuenta…

Étude de prévalence de l’endométriose à la Réunion et en métropole à partir du PMSI

2015

Introduction Objectif principal : determiner la prevalence des hospitalisations pour endometriose a la Reunion et en metropole. Objectif secondaire : apprecier l’evolution des soins chirurgicaux pour cette pathologie dans l’ile comparee a la metropole. L’endometriose est une maladie de la femme reglee. Les principaux modes de decouverte sont la douleur et l’infertilite. Le diagnostic de certitude repose sur la cœlioscopie et donc sur une hospitalisation. Methodes Du 1/01/2008 au 31/12/2012, a partir du PMSI national, nous avons releve les codes de diagnostic principal concernant l’endometriose (N800 a N809). Dans cette population, nous avons consulte les actes realises et ceux qui concernai…

Two Great Intricate Gestational Syndromes. New Screening and Treatment Strategies

2020

Abstract Gestational hypertension and premature birth frequently and independently affect the pregnancy prognosis with potentially detrimental influence of the pregnancy evolution. Pregnancy-induced hypertension, spectrum and categories of the systemic disease: gestational hypertension, preeclampsia, eclamsia, Hellp syndrome, overlapping preeclampsia (PE) chronic arterial hypertension, are some of the complications that can occur over the pregnancy evolution. Annually, preeclampsia affects approximately 4 million pregnancies. According to ACOG, preeclampsia complicates the evolution of pregnancies in a 2-8% ratio. According to WHO and FIGO, premature birth occurs after 37 weeks of complete …

Le défaut de soutien familial dans l’immédiat post-partum : quels impacts sur l’émergence de la détresse maternelle ?

2018

Resume But de l’etude Cette etude vise a evaluer l’impact du defaut de soutien familial dans l’immediat post-partum sur l’etat psychique maternelle et de son evolution 6 mois apres la naissance de l’enfant. Patients et methode Trente-cinq meres primipares, vivant maritalement, ayant beneficie des services d’hospitalisation a domicile (HAD) via leur maternite. Apres leur inclusion, elles ont ete reparties a posteriori en deux groupes, en fonction de la variable independante : soutien familial, obtenue via une utilisation libre du Social Support Questionnaire (SSQ6) de Sarason (1983 ; 1987), rempli par les participantes. La detresse maternelle a ete evaluee sur 4 temps de mesure (T1–2 semaine…

2019

Integral membrane proteins of the aquaporin family facilitate rapid water flux across cellular membranes in all domains of life. Although the water-conducting pore is clearly defined in an aquaporin monomer, all aquaporins assemble into stable tetramers. In order to investigate the role of protomer–protomer interactions, we analyzed the activity of heterotetramers containing increasing fractions of mutated monomers, which have an impaired oligomerization propensity and activity. In order to enforce interaction between the protomers, we designed and analyzed a genetically fused homotetramer of GlpF, the aquaglyceroporin of the bacterium Escherichia coli (E. coli). However, increasing fractio…

Roles for RpoS in survival of Escherichia coli during protozoan predation and in reduced moisture conditions highlight its importance in soil environ…

2017

The soil is a complex ecosystem where interactions between biotic and abiotic factors determine the survival and fate of microbial inhabitants of the system. Having previously shown that Escherichia coli requires the general stress response regulator, RpoS, to survive long term in soil, it was important to determine what specific conditions in this environment necessitate a functional RpoS. This study investigated the susceptibility of soil-persistent E. coli to predation by the single-celled eukaryotes Acanthamoeba polyphaga and Tetrahymena pyriformis, and the role RpoS plays in resisting this predation. Strain-specific differences were observed in the predation of E. coli strains, with so…

Computer-assisted sperm analysis and reproductive science; a gift for understanding gamete biology from multidisciplinary perspectives

2018

The science of reproductive biology has been a source of fascination for centuries and has been marked both by important landmarks of discovery and influential, but persistent, errors of fact. The first century physician and philosopher, Galen of Pergamum, carried out empirical investigations on both humans and animals and proposed that conception required a combination of both male and female ‘principles’…

Implantation failure of endometrial origin: what is new?

2018

To review recent findings related to possible causes of recurrent implantation failure of endometrial origin in normal uterus.Recent evidences suggest that in apparently normal endometria, RIF may associate with molecular and functional changes in the uterus such as abnormal endometrial microbiota, including the presence of chronic endometritis, poor synchronization between the blastocyst and endometrium, and/or excessive uterine peristalsis. An altered endometrial microbiota detected by molecular techniques has been recently related to poorer embryo implantation, even in apparently normal endometria. The use of the endometrial receptivity analysis test to obtain an objective signature of e…

Endometrial Receptivity Analysis (ERA): data versus opinions

2021

Abstract This article summarises and contextualises the accumulated basic and clinical data on the ERA test and addresses specific comments and opinions presented by the opponent as part of an invited debate. Progress in medicine depends on new technologies and concepts that translate to practice to solve long-standing problems. In a key example, combining RNA sequencing data (transcriptomics) with artificial intelligence (AI) led to a clinical revolution in personalising disease diagnosis and fostered the concept of precision medicine. The reproductive field is no exception. Translation of endometrial transcriptomics to the clinic yielded an objective definition of the limited time period …