Search results for "Tetrapyrroles"

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Radiolabelling and preliminary evaluation of 68Ga-tetrapyrrole derivatives as potential tracers for PET

2013

article i nfo Tetrapyrroles are multisided natural products which are of relevance in clinical medicine. Owing to their specific accumulation in tumour tissue, porphyrins, metalloporphyrins and chlorins have been used as in photodynamic therapy and optical imaging. Moreover, their specific uptake into inflammatory atheromatous plaques via LDL endocytosis has been reported. The present study is concerned with the synthesis of 68 Ga labelled porphyrin derivatives and an in vitro assessment of the utility of radiotracers in positron emission tomography. A set of five porphyrin derivatives were labelled using 68 Ga from a commercially obtained radionuclide generator. Dedicated post-processing o…

MaleCancer Researchmedicine.medical_treatmentGallium RadioisotopesPhotodynamic therapyEndocytosischemistry.chemical_compoundDrug StabilityRadioligandmedicineAnimalsHumansRadiology Nuclear Medicine and imagingRadiochemistrymedicine.diagnostic_testRadiochemistryBlood ProteinsPorphyrinTetrapyrroleIn vitroRatsTetrapyrroleschemistryBiochemistryPositron emission tomographyIsotope LabelingPositron-Emission TomographyMolecular MedicineRadionuclide GeneratorNuclear Medicine and Biology

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