Search results for "Therapeutics."
showing 10 items of 480 documents
Dietary water seems to improve skin hydration without influencing hemodynamics
2013
The various studies on the importance of water in the hydration of human skin have suggested that an increased dietary intake might positively impact the physiology of normal skin. We evaluated the consequences of increasing water intake through drinking in skin hydration in vivo. Eating habits were maintained, evaluated by a Food Frequency Questionnaire and based on total water consumption. In two groups with different total water consumption, we evaluated the impact of 2L/day water after 30 days,. This increase produced no hemodynamic changes or weight changes but an improvement in the epidermal hydration was suggested. The magnitude of the impact on skin hydration was higher in the group…
The Administration of Escherichia coli Nissle 1917 Ameliorates Development of DSS-Induced Colitis in Mice
2018
The beneficial effects of probiotics on immune-based pathologies such as inflammatory bowel disease (IBD) have been well reported. However, their exact mechanisms have not been fully elucidated. Few studies have focused on the impact of probiotics on the composition of the colonic microbiota. The aim of the present study was to correlate the intestinal anti-inflammatory activity of the probiotic Escherichia coli Nissle 1917 (EcN) in the dextran sodium sulfate (DSS) model of mouse colitis with the changes induced in colonic microbiota populations. EcN prevented the DSSinduced colonic damage, as evidenced by lower disease activity index (DAI) values and colonic weight/length ratio, when compa…
Ventilator-Associated Pneumonia in Patients with COVID-19: A Systematic Review and Meta-Analysis
2021
The aim of this systematic review and meta-analysis was to estimate the pooled occurrence of ventilator-associated pneumonia (VAP) among patients admitted to an intensive care unit with COVID-19 and mortality of those who developed VAP. We performed a systematic search on PubMed, EMBASE and Web of Science from inception to 2nd March 2021 for nonrandomized studies specifically addressing VAP in adult patients with COVID-19 and reporting data on at least one primary outcome of interest. Random effect single-arm meta-analysis was performed for the occurrence of VAP and mortality (at the longest follow up) and ICU length of stay. Twenty studies were included in the systematic review and meta-an…
Wiedza personelu pielęgniarskiego na temat ran przewlekłych i metod ich leczenia
2022
Cel pracy: Ustalenie poziomu wiedzy personelu pielęgniarskiego na temat ran przewlekłych i metod ich leczenia, jak również czynników determinujących poziom tej wiedzy. Materiał i metody: Zbadano 145 członków personelu pielęgniarskiego od listopada 2020 r. do stycznia 2021 r. Zastosowano metodę sondażu diagnostycznego techniką ankietowania. Narzędziem badawczym był autorski kwestionariusz ankiety. Wyniki: Grupa 78 (53,79%) uczestników ankiety miała wiedzę niedostateczną, 59 (40,69%) – dostateczną, 4 (2,76%) ankietowanych miało wiedzę dobrą, a pozostałych 4 (2,76%) – bardzo dobrą. Zaledwie 30 (20,69%) badanych znało klasyfikację służącą do oceny rany odleżynowej. Prawidłową kolejność układu f…
Pain neuroscience education and physical exercise for patients with chronic spinal pain in primary healthcare: a randomised trial protocol.
2019
AbstractBackgroundChronic musculoskeletal pain affects more than 20% of the population, and the prevalence is increasing, causing suffering, loss of quality of life, disability, and an enormous expenditure on healthcare resources. The most common location for chronic pain is the spine. Many of the treatments used are mainly passive (pharmacological and invasive) and poor outcomes. The treatments currently applied in the public health system do not comply with the recommendations of the main clinical practice guidelines, which suggest the use of educational measures and physical exercise as the first-line treatment. A protocol based on active coping strategies is described, which will be eva…
Bone targeting compounds for radiotherapy and imaging: *Me(III)-DOTA conjugates of bisphosphonic acid, pamidronic acid and zoledronic acid
2016
Background Bisphosphonates have a high adsorption on calcified tissues and are commonly used in the treatment of bone disorder diseases. Conjugates of bisphosphonates with macrocyclic chelators open new possibilities in bone targeted radionuclide imaging and therapy. Subsequent to positron emission tomography (PET) examinations utilizing 68Ga-labelled analogues, endoradiotheraphy with 177Lu-labelled macrocyclic bisphosphonates may have a great potential in the treatment of painful skeletal metastases. Methods Based on the established pharmaceuticals pamidronate and zoledronate two new DOTA-α-OH-bisphosphonates, DOTAPAM and DOTAZOL(MM1.MZ) were successfully synthesized. The ligands were labe…
Human DNA Telomeres in Presence of Oxidative Lesions: The Crucial Role of Electrostatic Interactions on the Stability of Guanine Quadruplexes
2019
By using all atom molecular dynamics simulations, we studied the behavior of human DNA telomere sequences in guanine quadruplex (G4) conformation and in the presence of oxidative lesions, namely abasic sites. In particular, we evidenced that while removing one guanine base induces a significant alteration and destabilization of the involved leaflet, human telomere oligomers tend, in most cases, to maintain at least a partial quadruplex structure, eventually by replacing the empty site with undamaged guanines of different leaflets. This study shows that (i) the disruption of the quadruplex leaflets induces the release of at least one of the potassium cations embedded in the quadruplex channe…
The life of relationship in globalized financial economic devices: Evidences from the experience of a group-analytic transcultural workshop
2014
The present contribution - starting from the experience of the EATGA Workshop 2011 that took place in Palermo and that had as its theme “Intersubjective bonds in the globalized economy” - invites to reflect on the quality of the life of relationship and intersubjective connectedness in social contemporary world. One of the characterizing cultural phenomena influencing contemporary reality is made up by the dominant and pervasive presence of logic and language of financial markets in policies and activities that organize and articulate daily life. Theoretical hypothesis driving our research is that the structures of subjectivity, the meaning and the way of being in a relationship are charact…
Identity vicissitudes in work organizations
2014
Today’s pressing scientific and technological changes, while having an impact on the organizational life of our post-industrial world, are producing drastic transformations within organizations, creating in workers new feelings of anxiety and uncertainty. The features of the present state of crises - instability, uncertainty, weakening of family bonds – define a peculiar social and psychological uneasiness, proper of our time, as a consequence of the technological business culture prevailing today, which is destabilizing the institutional role of organizations, namely fixing the various forms of personal identity. This contribution offers, also by presenting a training experience in a busin…
Mastering the Tools: Natural versus Artificial Vesicles in Nanomedicine
2020
Naturally occurring extracellular vesicles and artificially made vesicles represent important tools in nanomedicine for the efficient delivery of biomolecules and drugs. Since its first appearance in the literature 50 years ago, the research on vesicles is progressing at a fast pace, with the main goal of developing carriers able to protect cargoes from degradation, as well as to deliver them in a time- and space-controlled fashion. While natural occurring vesicles have the advantage of being fully compatible with their host, artificial vesicles can be easily synthetized and functionalized according to the target to reach. Research is striving to merge the advantages of natural and artifici…