Search results for "Third generation"
showing 7 items of 27 documents
Hydrophobic Encapsulated Phosphonium Salts-Synthesis of Weakly Coordinating Cations and their Application in Wittig Reactions
2015
Large and rigid tetraarylphosphonium tetrafluoroborate salts have been synthesized representing weakly coordinating cations with diameters of several nanometers. Divergent dendritic growth by means of thermal Diels-Alder cycloaddition was employed for the construction of the hydrophobic polyphenylene framework up to the third generation. X-ray crystal structure analysis of first-generation phosphonium tetrafluoroborate supported the rigidity of the non-collapsible shell around the phosphorus center and gave insight into solid-state packing and cation-anion distances. Copper(I)-catalyzed azide-alkyne ligation served as reliable method for the preparation of a first-generation triazolylphenyl…
Status of Recombinant Factor VIII Concentrate Treatment for Hemophilia A in Italy: Characteristics and Clinical Benefits
2019
The current interest in recombinant factor VIII (rFVIII) products stems from the fact that they offer a technological solution to prolonging the half-life of and reducing the risk of formation of alloantibodies (inhibitors) against FVIII in treated patients with hemophilia A (HA). The Italian health care system has authorized the use of a wide range of rFVIII concentrates of the first, second, and third generation, as well as new innovative rFVIII preparates with an extended half-life (EHL) (Kogenate FS®-Bayer, belonging to the second generation and replaced since 2017 by a product consisting of the same modified molecule; because it is only available until the end of the current year, it w…
Determination of Third-Generation Synthetic Cannabinoids in Oral Fluids.
2020
Abstract A procedure has been developed for the determination of third-generation synthetic cannabinoids in oral fluid samples by using a semi-automated microextraction by packed sorbent (MEPS) procedure and gas chromatography–mass spectrometry (GC–MS) determination. Five synthetic cannabinoids were employed as model compounds 5F-ADB, MMB-CHMICA, THJ-2201, CUMYL-4CN-BINACA and MDMB-CHMCZCA. The most adequate operative conditions for MEPS were evaluated giving quantitative recoveries, from 89 to 124%, in synthetic and field saliva samples spiked with 125 and 250 μg/L of the studied cannabinoids, with the exception of MDMB-CHMCZCA in field saliva samples that provided slightly lower recoverie…
THIRD GENERATION LEARNING IN BUSINESS ENGLISH
2016
Third generation learning in Business English is a tool increasing students’ life-long competences and achievements. Business English today is about communication where the content and the communicative competences- linguistic, sociolinguistic and pragmatic are of crucial importance. The article reflects the results of 3rd generation learning in Business English in post-secondary institution in Latvia where students using team-based learning in the classroom mastered their language skills and communicative competences to achieve an academic success.
Proces wrastania autochtonów i przesiedleńców w nową przestrzeń kulturową na Śląsku po II wojnie światowej
2019
In compliance with the resolutions made at the Yalta Conference in 1945, new borders of the post-warPolish state were demarcated and the necessity of displacing the German population from the lands incorporated into Poland was agreed upon. This led to mass-scale displacements of the population from theformer eastern lands of the Second Republic of Poland to the so-called Recovered Territories (or WesternLands), which in turn triggered the exceptionally traumatic process of people’s “growing into” the new space. The author follows this complicated and long-lasting process, using the example of the Opole Region,where two communities co-existed side by side: the displaced and the autochthonous…
Innovative, Translucent and Multi-functional Components for the Building Envelope: technological and performance optimization
2017
The paper describes the actions aimed at the technology and performance optimization of an innovative, multi-functional building component made of precast and pre-stressed glass blocks useful for the construction of sustainable building envelopes able to reduce the energy consumption and to produce clean energy from the sun. The design optimization of different sub-components and the choice of the right materials for guaranteeing their good response in terms of mechanical resistance, thermal and acoustic insulation, light transmission, electricity production, integration with other components, dimensional coordination, are particularly described.
Inhaled anesthesia in neurosurgery: Still a role?
2021
In patients undergoing craniotomy, general anesthesia should be addressed to warrant good hypnosis, immobility, and analgesia, to ensure systemic and cerebral physiological status and provide the best possible surgical field. Regarding craniotomies, it is unclear if there are substantial differences in providing general anesthesia using total intravenous anesthesia (TIVA) or balanced anesthesia (BA) accomplished using the third generation halogenates. New evidence highlighted that the last generation of halogenated agents has possible advantages compared with intravenous drugs: rapid induction, minimal absorption and metabolization, reproducible pharmacokinetic, faster recovery, cardioprote…