Search results for "Three-Dimensional"

Red blood with blue-blood ancestry: Intriguing structure of a snail hemoglobin

2006

The phylogenetic enigma of snail hemoglobin, its isolated occurrence in a single gastropod family, the Planorbidae, and the lack of sequence data, stimulated the present study. We present here the complete cDNA and predicted amino acid sequence of two hemoglobin polypeptides from the planorbid Biomphalaria glabrata (intermediate host snail for the human parasite Schistosoma mansoni ). Both isoforms contain 13 different, cysteine-free globin domains, plus a small N-terminal nonglobin “plug” domain with three cysteines for subunit dimerization (total M r ≈ 238 kDa). We also identified the native hemoglobin molecule and present here a preliminary 3D reconstruction from electron microscopical …

Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia

2021

Abstract SARS-CoV-2 vaccine ChAdOx1 nCoV-19 (AstraZeneca) causes a thromboembolic complication termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Using biophysical techniques, mouse models, and analysis of VITT patient samples, we identified determinants of this vaccine-induced adverse reaction. Super-resolution microscopy visualized vaccine components forming antigenic complexes with platelet factor 4 (PF4) on platelet surfaces to which anti-PF4 antibodies obtained from VITT patients bound. PF4/vaccine complex formation was charge-driven and increased by addition of DNA. Proteomics identified substantial amounts of virus production-derived T-REx HEK293 proteins in the ethyle…

Development and evaluation of 3-dimensional printed models of the human tracheobronchial system for training in flexible bronchoscopy.

2017

OBJECTIVES Training and assessment of proper skills in flexible bronchoscopy are major educational goals for cardiothoracic residents. Therefore, we developed 3-dimensional (3D) printed models of the human tracheobronchial system for training and assessment of cardiothoracic residents in flexible bronchoscopy. METHODS Three models of normal (size/shape) human tracheobronchial anatomy were generated using a commercially available 3D printer. Ten residents (inexperienced: Group 1; experienced: Group 2) participated in this study with an experimental setting of initial assessment (Model 1), training (15 min, Model 2) and post-training assessment (Model 3). The time needed for flexible bronchos…

Computational analysis to predict false-lumen perfusion and outcome of type B aortic dissection.

2014

We have attempted to identify potential predictors foracute and late aortic events starting from admission computed tomographic images.

Mitral valve annuloplasty and papillary muscle relocation oriented by 3-dimensional transesophageal echocardiography for severe functional mitral reg…

2012

Objective The study of the mitral valve apparatus and its modifications during functional mitral regurgitation (FMR) is better revealed by 3-dimensional (3D) transesophageal echocardiography (TOE). To plan mitral valve repair by annuloplasty and papillary muscle (PPM) relocation, we proposed a valve repair procedure oriented by the new main features obtained by real-time 3D TOE reconstruction of the mitral valve apparatus. Methods Since January 2008, 25 patients with severe FMR before mitral valve repair were examined. Mean coaptation depth and mean tenting area were 1.3 ± 0.2 cm and 3.2 ± 0.5 cm 2 , respectively. Intraoperative 2D and 3D TOE were performed, followed by a 3D offline reconst…

DEVELOPMENT OF NONTOXIC BIO-ADHESIVES FOR WET ENVIRONMENTS

2021

Metamagnetism in hydrophobically induced carboxylate (phenylmalonate)-bridged copper(II) layers

2006

Self-assembly of copper(II) ions, phenylmalonate and pyrimidine yields the layered compound [Cu(pym)(Phmal)]n ( 1) where intralayer ferro- and interlayer antiferromagnetic interactions occur with three-dimensional antiferromagnetic ordering at Tc = 2.15 K Lloret Pastor, Francisco, Francisco.Lloret@uv.es ; Julve Olcina, Miguel, Miguel.Julve@uv.es

Nanotechnology, and scaffold implantation for the effective repair of injured organs: An overview on hard tissue engineering

2020

The tissue engineering of hard organs and tissues containing cartilage, teeth, and bones is a widely used and rapidly progressing field. One of the main features of hard organs and tissues is the mineralization of their extracellular matrices (ECM) to enable them to withstand pressure and weight. Recently, a variety of printing strategies have been developed to facilitate hard organ and tissue regeneration. Fundamentals in three-dimensional (3D) printing techniques are rapid prototyping, additive manufacturing, and layered built-up and solid-free construction. This strategy promises to replicate the multifaceted architecture of natural tissues. Nowadays, 3D bioprinting techniques have prove…

Metodi automatici di analisi e caratterizzazione di esami radiologici del massiccio facciale.

L'obiettivo di questo lavoro è lo sviluppo di algoritmi e procedure di analisi di referti radiografici digitali di tipo CBCT delle strutture della mandibola e dell’apparato dentario. In particolare, mediante un’opportuna campagna di sperimentazione, in collaborazione con i reparti di radiologia ed odontoiatria del Policlinico di Palermo, è stata realizzata un procedura in grado di: • eliminare i problemi di sovrapponibilità dei referti tridimensionali effettuati in tempi successivi; • identificare lo spazio parodontale su indagini CBCT per la valutazione dei possibili difetti nello stesso e prevedere l’insorgenza di parodontiti. • individuare gli elementi di maggiore interesse medico caratt…

[Current developments and perspectives on the diagnosis and treatment of urinary incontinence and genital prolapse in women].

2012

As a key area of gynaecology, urogynaecology has undergone impressive changes in the past few years. Together with the high prevalence of functional pelvic floor disorders, modern anaesthesia procedures and the introduction of new, innovative minimally invasive operation techniques have led to a dramatic increase in the number of operations for incontinence and prolapses. The increasingly subtle diagnostic options, such as, e. g., 2D and 3D sonography of the pelvic floor provide unambiguous findings and facilitate decision making. Tension-free vaginal slings in retro-pubic, trans-obturator or single-incision techniques show a high success rate with few complications and have almost complete…