Search results for "Time"

showing 10 items of 12336 documents

Kaon femtoscopy in Pb-Pb collisions at √sNN=2.76 TeV

2017

We present the results of three-dimensional femtoscopic analyses for charged and neutral kaons recorded by ALICE in Pb-Pb collisions at √ s NN = 2.76 TeV. Femtoscopy is used to measure the space-time characteristics of particle production from the effects of quantum statistics and final-state interactions in two-particle correlations. Kaon femtoscopy is an important supplement to that of pions because it allows one to distinguish between different model scenarios working equally well for pions. In particular, we compare the measured three-dimensional kaon radii with a purely hydrodynamical calculation and a model where the hydrodynamic phase is followed by a hadronic rescattering stage. The…

:Kjerne- og elementærpartikkelfysikk: 431 [VDP]Pb-PbHadronNuclear TheoryPb-Pb collisionshiukkasfysiikkaHEAVY-ION COLLISIONSPPCOLLABORATION7. Clean energy01 natural sciencesParticle identificationHYDRODYNAMICSALICEDEPENDENCENuclear ExperimentPhysicsCOULOMB CORRECTIONSTime projection chamberLarge Hadron ColliderVDP::Kjerne- og elementærpartikkelfysikk: 431PRIRODNE ZNANOSTI. Fizika.:Nuclear and elementary particle physics: 431 [VDP]VDP::Nuclear and elementary particle physics: 431BOSE-EINSTEIN CORRELATIONSTransverse massLHCkaonParticle physicsNuclear and High Energy PhysicskaonsNuclear physicsINTERFEROMETRYPionfemtoscopy0103 physical sciencesNuclear and High Energy Physics; ALICE; LHCPARTICLESparticle physics010306 general physicsScalingNuclear and High Energy Physicta114010308 nuclear & particles physics2.76TeVHEAVY-ION COLLISIONS; BOSE-EINSTEIN CORRELATIONS; COULOMB CORRECTIONS; INTERFEROMETRY; MATTER; PP; COLLABORATION; HYDRODYNAMICS; DEPENDENCE; PARTICLESBose–Einstein correlationsNATURAL SCIENCES. Physics.High Energy Physics::ExperimentMATTERkaon femtoscopy Pb-Pb 2.76TeV
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Measurement of spin-orbital angular momentum interactions in relativistic heavy-ion collisions

2020

The first evidence of spin alignment of vector mesons ($K^{*0}$ and $\phi$) in heavy-ion collisions at the Large Hadron Collider (LHC) is reported. The spin density matrix element $\rho_{00}$ is measured at midrapidity ($|y| <$ 0.5) in Pb-Pb collisions at a center-of-mass energy ($\sqrt{s_{\rm NN}}$) of 2.76 TeV with the ALICE detector. $\rho_{00}$ values are found to be less than 1/3 (1/3 implies no spin alignment) at low transverse momentum ($p_{\rm T} <$ 2 GeV/$c$) for $K^{*0}$ and $\phi$ at a level of 3$\sigma$ and 2$\sigma$, respectively. No significant spin alignment is observed for the $K^0_S$ meson (spin = 0) in Pb-Pb collisions and for the vector mesons in $pp$ collisions. The meas…

:Kjerne- og elementærpartikkelfysikk: 431 [VDP]heavy ion: scatteringPhysics::Instrumentation and Detectorsheavy ion collisionsNuclear TheoryHadronGeneral Physics and AstronomyhiukkasfysiikkaGLOBAL POLARIZATION; ALIGNMENT; MESONS; LAMBDA; QCDhyperonnucl-ex01 natural sciences2760 GeV-cms/nucleonRelativistic heavy ionspin-orbitalHeavy ion experimentsHigh Energy Physics - ExperimentHigh Energy Physics - Experiment (hep-ex)ALICE[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]Nuclear Experiment (nucl-ex)spin: density matrixNuclear ExperimentNuclear ExperimentPhysicsPhysicselliptic flowElliptic flowVDP::Kjerne- og elementærpartikkelfysikk: 431spin: alignmentMESONSvector mesonHadronizationLAMBDAddc:PRIRODNE ZNANOSTI. Fizika.ALIGNMENT:Nuclear and elementary particle physics: 431 [VDP]CERN LHC CollVDP::Nuclear and elementary particle physics: 431Spin-orbit angular momentumParticle Physics - ExperimentQuarkAngular momentumMesonFOS: Physical sciencestransverse momentum[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex]Physics and Astronomy(all)Relativistic heavy ionsangular momentum114 Physical sciences530Nuclear physicspolarization: measuredSpin-orbit angular momentum heavy ion collisions0103 physical sciencesddc:530decay: angular distributionNuclear Physics - ExperimentVector mesonGLOBAL POLARIZATION010306 general physicsNuclear Physicshep-exHigh Energy Physics::PhenomenologyHyperonQCDNATURAL SCIENCES. Physics.recombinationRelativistic heavy ions; spin-orbitalspin (kvanttimekaniikka)correlationHigh Energy Physics::Experimentquark: polarizationspin-orbital angular momentum interactions ; heavy-ion collisionshadronizationexperimental results
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Probing the Effects of Strong Electromagnetic Fields with Charge-Dependent Directed Flow in Pb-Pb Collisions at the LHC

2020

The first measurement at the LHC of charge-dependent directed flow ($v_{1}$) relative to the spectator plane is presented for Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 5.02 TeV. Results are reported for charged hadrons and $\rm D^{0}$ mesons for the transverse momentum intervals $p_{\rm T}>0.2$ GeV/$c$ and $3<p_{\rm T}<$ 6 GeV/$c$ in the 5-40% and 10-40% centrality classes, respectively. The difference between the positively and negatively charged hadron $v_{1}$ has a positive slope as a function of pseudorapidity $\eta$, ${\rm d}\Delta{v_1}/{\rm d}\eta=$[1.68 $\pm$ 0.49 (stat.) $\pm$ 0.41 (syst.)] $\times 10^{-4}$. The same measurement for $\rm D^{0}$ and $\rm\bar{D}{}^0$ mesons yields a p…

:Kjerne- og elementærpartikkelfysikk: 431 [VDP]heavy ion: scatteringflow: charge dependenceHadronGeneral Physics and Astronomyhiukkasfysiikkanucl-exmeson: yield01 natural sciencesHeavy ion experimentsHigh Energy Physics - ExperimentHigh Energy Physics - Experiment (hep-ex)electromagnetic field: highPb-Pb at LHC; flow[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]Charm (quantum number)Nuclear Experiment (nucl-ex)Nuclear ExperimentNuclear ExperimentMAGNETIC-FIELD; QCDQuantum chromodynamicsPhysicshigh [electromagnetic field]PhysicsMAGNETIC-FIELDVDP::Kjerne- og elementærpartikkelfysikk: 4313. Good healthquark gluon plasmaddc:PRIRODNE ZNANOSTI. Fizika.:Nuclear and elementary particle physics: 431 [VDP]CERN LHC CollVDP::Nuclear and elementary particle physics: 431charge dependence [flow]Pseudorapidityflowhadron: charged particlehadron: chargeParticle Physics - Experimentyield [meson]QuarkMesonFOS: Physical sciences[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex]transverse momentumPhysics and Astronomy(all)spectator114 Physical sciencesNuclear physicsscattering [heavy ion]0103 physical sciencesPb-Pb at LHCRapidityNuclear Physics - Experimentddc:5305020 GeV-cms/nucleoncharged particle [hadron]010306 general physicsNuclear Physicshep-excharge dependenceHigh Energy Physics::PhenomenologysensitivityQCDNATURAL SCIENCES. Physics.rapidityspin (kvanttimekaniikka)Quark–gluon plasmaHigh Energy Physics::Experimentstrong electromagnetic fields ; Pb-Pb Collisionsexperimental results
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L'estudi de la deshumanització i la infrahumanització en psicologia

2010

L'estudi psicosocial sobre la conducta antisocial i la crueltat dels éssers humans reconeix l'existència d'una representació deshumanitzadora de l'altre. El propòsit d'aquest article és presentar els avanços empírics en l'estudi de la infrahumanització, com a atribució diferencial de sentiments en l'endogrup i en l'exogrup. Atès que els sentiments 'per exemple, l'amor, l'esperança, el menyspreu, el ressentiment' es consideren emocions exclusivament humanes, les persones no sols atribueixen més sentiments a l'endogrup que no als exogrups, sinó que neguen a aquests últims la capacitat de vivenciar-ne. Ara oferim, en primer lloc, una descripció de les distintes perspectives que s'han utilitzat…

:PSICOLOGÍA [UNESCO]Conducta antisocial deshumanització infrahumanització intervencions representació sentiments Antisocial behavior dehumanization infrahumanization interventions representation emotions. ArtículoUNESCO::PSICOLOGÍA
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Identification of isomeric states in the N=73 neutron-deficient nuclei 132Pr and 130La

2012

Decays from isomeric states in the neutron-deficient N=73 nuclei 132Pr and 130La have been observed for the first time. Half-lives of 486(70) ns and 2.46(4) μs were measured for two isomeric states in 132Pr. The decay from the 486ns (8 -) isomer has been interpreted as a hindered E1 transition from the bandhead state of the excited πh 11/2νg 7/2 configuration. The decay from the 2.5 μs (8 +) isomer is consistent with the Weisskopf estimate for a low-energy E2 transition. An analogous 0.74(3) μs decay from an (8 +) isomer in the neighboring isotone 130La has also been observed which similarly can be explained if the transition has E2 character. The Weisskopf interpretation for the isomer hin…

=A\&ltIsomer decay90<=A<=14990\&ltddc:530LifetimesExperimental nuclear physics[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex]=149gamma transitions and level energiesKokeellinen ydinfysiikka
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Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

ABCC1 ATP binding cassette subfamily C member 1IC50 half maximal inhibitory concentrationMultidrug resistancePharmacologyNADPH reduced nicotinamide adenine dinucleotide phosphateF bioavailabilitychemistry.chemical_compoundPCR polymerase chain reaction0302 clinical medicineMDR multidrug resistanceECL electrochemiluminescencet1/2 elimination half-lifeLC–MS liquid chromatography coupled with mass spectrometryN.D. not detectedGeneral Pharmacology Toxicology and PharmaceuticsBBB blood–brain barriermedia_commonATF3 activating transcription factor 30303 health sciencesChemistryABC ATP-binding cassetteNMPA National Medical Products AdministrationPXR pregnane X receptorSDS-PAGE sodium dodecyl sulfate-polyacrylamide gel electrophoresisHBSS Hankʹs balanced salt solutionABCB1Combination chemotherapyProdrugMarsdenia tenacissimaCmax peak concentrationPaclitaxelGAPDH glyceraldehyde-3-phosphate dehydrogenase030220 oncology & carcinogenesisBHI brain heart infusionOriginal ArticleAUC0–∞ area under plasma concentration vs. time curveMRT mean residence timeDrugmedia_common.quotation_subjectRM1-950Vd volume of distributionABCB1 ATP binding cassette subfamily B member 1UIC-2 mouse monoclonal ABCB1 antibodyABCG2 ATP binding cassette subfamily G member 2Combination chemotherapyCYP cytochrome P450 isozymePI propidium iodideTEER transepithelial electrical resistance03 medical and health sciencesPBS phosphate buffer salineFBS fetal bovine serumDox doxorubicinIn vivoPOP polyoxypregnanemedicine030304 developmental biologyEVOM epithelial tissue voltohmmeterTmax time for peak concentrationCancerLBE lowest binding energyPE phycoerythrinmedicine.diseaseMultiple drug resistancePolyoxypregnanePapp apparent permeabilityN.A. not applicableCancer cellH&E hematoxylin and eosinMDR1a multidrug resistance protein 1aTherapeutics. PharmacologyqPCR quantitative PCRM. tenacissima Marsdenia tenacissimaCL clearanceSD standard derivationActa Pharmaceutica Sinica B
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Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease.

2009

The alpha-secretase cleaves in the non-amyloidogenic pathway the amyloid-beta protein precursor (AbetaPP) within the region of the amyloid-beta peptides to prevent their formation and aggregation in the brain. Members of the ADAM family (a disintegrin and metalloprotease) are the main candidates for physiologically relevant alpha-secretases. We recently demonstrated that overexpression of ADAM10 in mice transgenic for human AbetaPP (ADAM10 x APP[V717I]) alleviated functional deficits related to Alzheimer's disease. To further demonstrate that this is due to the specific activity of alpha-secretase, we characterized mice overexpressing an inactive form of ADAM10 (ADAM10[E384A]; ADAM10-dn). T…

ADAM10Morris water navigation taskGlutamic AcidStimulationMice TransgenicADAM10 ProteinAmyloid beta-Protein PrecursorMiceIn vivoAlzheimer DiseaseDisintegrinReaction TimeAnimalsHumansIsoleucineProtein precursorMaze LearningSwimmingMetalloproteinaseAlaninebiologyBehavior AnimalChemistryGeneral NeuroscienceAge FactorsMembrane ProteinsValineGeneral MedicineCell biologyMice Inbred C57BLPsychiatry and Mental healthClinical PsychologyADAM ProteinsDisease Models Animalbiology.proteinSpecific activityGeriatrics and GerontologyAmyloid Precursor Protein SecretasesJournal of Alzheimer's disease : JAD
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'I love Rock 'n' Roll'--music genre preference modulates brain responses to music.

2013

The present study examined the effect of participants' music genre preference on the neural processes underlying evaluative and cognitive judgements of music using the event-related potential technique. To this aim, two participant groups differing in their preference for Latin American and Heavy Metal music performed a liking judgement and a genre classification task on a variety of excerpts of either music genre. A late positive potential (LPP) was elicited in all conditions between 600 and 900 ms after stimulus onset. During the genre classification task, an early negativity was elicited by the preferred compared to the non-preferred music at around 230-370 ms whereas the non-preferred g…

AESTHETICSMaleEvent-related potentialEvaluative processingmedia_common.quotation_subjectJudgementEVENT-RELATED POTENTIALSNEGATIVITY BIAS050105 experimental psychologyDevelopmental psychology03 medical and health sciences0302 clinical medicineEvent-related potentialPerceptionCATEGORIZATIONNegativity biasEMOTIONROUGHNESSReaction TimeHumans0501 psychology and cognitive sciencesValence (psychology)Music genre preferenceta515media_commonPERCEPTIONAnalysis of VarianceBrain MappingLate positive potential (LPP)General Neuroscience05 social sciencesBrainCognitionElectroencephalographyNeuropsychology and Physiological PsychologyEarly negativityCategorizationAcoustic StimulationMusic and emotionAuditory PerceptionEvoked Potentials AuditoryFemalePsychologyELECTROPHYSIOLOGICAL INDEXESSENSORY CONSONANCEERP030217 neurology & neurosurgeryMusicBiological psychology
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Updated measurement of the τ lepton lifetime

1997

A new measurement of the mean lifetime of the tau lepton is presented. Three different analysis methods are applied to a sample of 90000 tau pairs, collected in 1993 and 1994 with the ALEPH detector at LEP. The average of this measurement and those previously published by ALEPH is tau_tau = 290.1 +- 1.5 +- 1.1 fs.

ALEPH Experiment; LEP; Tau lifetimeNuclear and High Energy PhysicsParticle physicsAleph[PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex]Electron–positron annihilationFOS: Physical sciences01 natural sciencesTau lifetimeHigh Energy Physics - ExperimentNuclear physicsALEPH ExperimentHigh Energy Physics - Experiment (hep-ex)0103 physical sciences[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]010306 general physicsALEPH experimentAnalysis methodPhysics010308 nuclear & particles physicsPhysicsDetectorSettore FIS/01 - Fisica SperimentaleLEPSample (graphics)Particle Physics - ExperimentLepton
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Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease.

2022

Funder: European Commission

ALTtype 2 diabetes mellitusROC receiving operator characteristicaspartate aminotransferaseHSDLDL low-density lipoproteinUHPLC ultrahigh-performance liquid chromatographyROCHCCNon-alcoholic steatohepatitisGCPCANASHGastroenterology2-HB 2-hydroxybutanoic acid; 3-HB 3-hydroxybutanoic acid; ALT alanine aminotransferase; AST aspartate aminotransferase; CE cholesterol ester; Cer ceramide; FFA free fatty acid; FLIP Fatty Liver Inhibition of Progression; Fibrosis; GC gas chromatography; HCC hepatocellular carcinoma; HSD honest significant difference; LC lipid cluster; LDL low-density lipoprotein; LM lipid and metabolite; LMC lipid metabolite and clinical variable; LPC lysophosphatidylcholine; Lipidomics; Mass spectrometry; Metabolomics; NAFL non-alcoholic fatty liver; NAFLD non-alcoholic fatty liver disease; NAS NASH activity score; NASH non-alcoholic steatohepatitis; NIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research Network; NRR non-rejection rate; Non-alcoholic steatohepatitis; PC(O) ether PC; PC phosphatidylcholine; PCA principal component analysis; PE phosphatidylethanolamine; QTOFMS quadrupole-time-of-flight mass spectrometry; ROC receiving operator characteristic; SAF steatosis activity and fibrosis; SM sphingomyelin; T2DM type 2 diabetes mellitus; TG triacylglycerol; UHPLC ultrahigh-performance liquid chromatographySAFSAF steatosis activity and fibrosisLM lipid and metabolitehonest significant differenceHSD honest significant differenceTG triacylglycerolnon-rejection ratecholesterol esterPCPEGC gas chromatographyfree fatty acidFLIPNASH non-alcoholic steatohepatitisNIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research NetworkBIOMARKERST2DMPE phosphatidylethanolamineLDLlipidNAFLDFFA free fatty acid2-HBMetabolomicsNAFL non-alcoholic fatty liverLMCphosphatidylcholineScience & TechnologySM sphingomyelinGastroenterology & HepatologyMass spectrometryactivitynutritional and metabolic diseasesT2DM type 2 diabetes mellitusACIDSreceiving operator characteristicdigestive system diseasesquadrupole-time-of-flight mass spectrometryLC lipid clusterlow-density lipoproteinNAS2-HB 2-hydroxybutanoic acidNAS NASH activity scoreQTOFMSether PCNRRSCORING SYSTEMprincipal component analysisgas chromatographyLC2-hydroxybutanoic acidPROGRESSIONAST aspartate aminotransferaseLMPC phosphatidylcholinePC(O)MARKERSUHPLCsteatosisTOOLImmunology and AllergyINSULIN-RESISTANCECerSMFatty Liver Inhibition of Progressionhepatocellular carcinoma2-HB 2-hydroxybutanoic acid NIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research Network NRR non-rejection rate Non-alcoholic steatohepatitis PC(O) ether PC PC phosphatidylcholine PCA principal component analysis PE phosphatidylethanolamine QTOFMS quadrupole-time-of-flight mass spectrometry ROC receiving operator characteristic SAF steatosis activity and fibrosis SM T2DM type 2 diabetes mellitus TG triacylglycerol UHPLC ultrahigh-performance liquid chromatographyultrahigh-performance liquid chromatographyCELPC3-HBNAFLnon-alcoholic fatty liverTGtriacylglycerolNRR non-rejection rateLife Sciences & BiomedicineNAFLD non-alcoholic fatty liver diseaseFLIP Fatty Liver Inhibition of Progressionalanine aminotransferasemetaboliteCer ceramideCE cholesterol estersphingomyelinlysophosphatidylcholineand fibrosisALT alanine aminotransferaseInternal MedicineceramideNational Institute of Digestive Diseases and Kidney NASH Clinical Research NetworkAST3-HB 3-hydroxybutanoic acidQTOFMS quadrupole-time-of-flight mass spectrometryPCA principal component analysisLPC lysophosphatidylcholineHepatologynon-alcoholic fatty liver diseaseand clinical variablePC(O) ether PC3-hydroxybutanoic acidFibrosisNASH activity scoreNIDDK NASH-CRNlipid clusterlipid and metabolitephosphatidylethanolamineLipidomicsLMC lipid metabolite and clinical variableFFAHCC hepatocellular carcinomaJHEP reports : innovation in hepatology
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