Search results for "Timing"
showing 10 items of 126 documents
The effect of early or late R&D inbound alliance on innovation
2016
In the research-and-development (R&D) supply chain, firms can agree an inbound alliance at different times along the R&D process; this decision affects the supplier's effort and the innovation that firms achieve at the end of the agreement. Because the supplier's effort is not entirely observable, firms cannot enforce effort contractually. Early contracts demand greater effort and offer risk-sharing opportunities; in late contracts suppliers have a stronger ex-ante bargaining-power position because of the shorter (and less risky) contract length and the experience suppliers already have. This study argues that later inbound alliances allow a higher innovation value when both partner…
Learning to perceive time: A connectionist, memory-decay model of the development of interval timing in infants
2011
International audience; We present the first developmental model of interval timing. It is a memory-based connectionist model of how infants learn to perceive time. It has two novel features that are not found in other models. First, it uses the uncertainty of a memory for an event as an index of how long ago that event happened. Secondly, embodiment – specifically, infant motor activity – is crucial to the calibration of time-perception both within and across sensory modalities. We describe the model and present three simulations which show (1) how it uses sensory memory uncertainty and bodily representaions to index time, (2) that the scalar property of interval timing (Gibbon, 1977) emer…
The real-life performance of market timing with moving average and time-series momentum rules
2014
In this article, we revisit the myths regarding the superior performance of market timing strategies based on moving average and time-series momentum rules. These active timing strategies are very appealing to investors because of their extraordinary simplicity and because they promise substantial advantages over their passive counterparts. However, the ‘too good to be true’ reported performance of these market timing rules raises a legitimate concern as to whether this performance is realistic and whether investors can expect that future performance will be the same as the documented historical performance. We argue that the reported performance of market timing strategies usually contains…
A real options game of alliance timing decisions in biopharmaceutical research and development
2017
Abstract In this article we examine the alliance timing trade-off facing both pharmaceutical and biotech firms in a stochastic and competitive environment. Specifically, we introduce a real options game (ROG), where a pharmaceutical company can choose between two competing biotech firms by sequentially offering a licensing deal early or late in the new drug development process. We find that, when the alliance raises the drug market value significantly, the agreement is signed late in the drug development process. This suggests that the postponement effect implied by the use of real options prevails over the biotech firms’ competition effect, which would instead play in favor of an early agr…
Timing effect of intramyocardial hydrogel injection for positively impacting left ventricular remodeling after myocardial infarction
2015
Intramyocardial injection of various injectable hydrogel materials has shown benefit in positively impacting the course of left ventricular (LV) remodeling after myocardial infarction (MI). However, since LV remodeling is a complex, time dependent process, the most efficacious time of hydrogel injection is not clear. In this study, we injected a relatively stiff, thermoresponsive and bioabsorbable hydrogel in rat hearts at 3 different time points - immediately after MI (IM), 3 d post-MI (3D), and 2 w post-MI (2W), corresponding to the beginnings of the necrotic, fibrotic and chronic remodeling phases. The employed left anterior descending coronary artery ligation model showed expected infar…
Phase dynamics in graphene-based Josephson junctions in the presence of thermal and correlated fluctuations
2014
In this work we study by numerical methods the phase dynamics in ballistic graphene-based short Josephson junctions. The supercurrent through a graphene junction shows a non-sinusoidal phase-dependence, unlike a conventional junction ruled by the well-known d.c. Josephson relation. A superconductor-graphene-superconductor system exhibits superconductive quantum metastable states similar to those present in normal current-biased JJs. We explore the effects of thermal and correlated fluctuations on the escape time from these metastable states, when the system is stimulated by an oscillating bias current. As a first step, the analysis is carried out in the presence of an external Gaussian whit…
Investigation of LaBr3(Ce) detectors at the RITU focal plane
2015
The aims of this master thesis were to determine the absolute detection efficiency of the LaBr3(Ce) detectors installed at the RITU focal plane, to study the effect of planar Ge-detector on the LaBr3(Ce) efficiency and to investigate the possibility of half-life measurements with the detectors in a coincidence setup having distributed recoil ions produced by the RITU separator. Time spectra were collected by moving a point radioactive source from one edge of the implantation detector to the other to imitate the ion distribution from the RITU separator. Simulations have been exploited to explore the time spectra obtained from various ion distribution shapes and for different half-lives. A po…
Sex Allocation Theory for Facultatively Sexual Organisms Inhabiting Seasonal Environments: The Importance of Bet Hedging
2018
Adaptive explanations for dormancy often invoke bet hedging, where reduced mean fitness can be adaptive if it associates with reduced fitness variance. Sex allocation theory typically ignores variance effects and focuses on mean fitness. For many cyclical parthenogens, these themes become linked, as only sexually produced eggs undergo the dormancy needed to survive harsh conditions. We ask how sex allocation and the timing of sex evolve when this constraint exists in the form of a trade-off between asexual reproduction and sexual production of dormant eggs-the former being crucial for within-season success and the latter for survival across seasons. We show that male production can be tempo…
Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
2021
This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index 60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models wer…
Childhood history of abuse and child abuse potential: The role of parent's gender and timing of childhood abuse
2014
It has been suggested that being physically abused leads to someone becoming a perpetrator of abuse which could be associated to parents' gender, timing of the physical abuse and specific socio-demographic variables. This study aims to investigate the role the parents' gender, timing of childhood abuse and socio-demographic variables on the relationship between parents' history of childhood physical abuse and current risk for children. The sample consisted of 920 parents (414 fathers, 506 mothers) from the Portuguese National Representative Study of Psychosocial Context of Child Abuse and Neglect who completed the Childhood History Questionnaire and the Child Abuse Potential Inventory. The …