Search results for "Timo"

INTERNATIONALISATION OF SMALL AND MEDIUM SICILIAN WINERIES: AN EXPLORATORY STUDY BASED ON THE RBV APPROACH

2014

Strategies of internationalization, such as export, have a central role as well to safeguard the market position and survival for many enterprises, including small and medium ones. The aim of this study is to investigate, through a resource-based view (RBV) approach, the main firms' internal factors that affect the export propensity of sparkling wines producers in Sicily and their ability to insert into foreign market. Based on review of extant literature we have identified the main factors, related both to the firms and to the managers characteristics, that affect the firm performance in the export market. Using survey data of 94 Sicilian small and medium wineries export oriented, this pap…

Hakukonemarkkinoinnin tehokkuus B2B ja B2C asiakkaille autonvuokrausalalla Suomessa

2012

Internetin nopea kasvu kaupankäynti-, viihde ja tietomediaksi on johtanut siihen, että yritysten on oltava internetissä. Internetin myötä perinteisesti markkinointiviestintää hallinneet markkinoinninkeinot ovat menettäneet asemaansa verkkomainonnan voimakkaan kasvun kustannuksella. Nopea kasvu on tuonut mukanaan haasteita; kuinka saada oma verkkosivusto kohdeyleisön tietoisuuteen oikealla hetkellä? Yksi vastaus haasteeseen ovat hakukoneet. Hakukonemarkkinointi voi olla oikein hyödynnettynä tehokas apuväline kohderyhmän ohjaamisessa yrityksen verkkosivuille. Hakukonemarkkinointi koostuu kahdesta tekniikasta, hakukonemainonnasta ja hakukoneoptimoinnista, joihin tässä tutkimuksessa perehdytään…

Resdagböcker på Internet som en kommunikativ genre

2012

Current Concepts and Perspectives on Brain Arteriovenous Malformations: A Review of Pathogenesis and Multidisciplinary Treatment.

2021

Brain arteriovenous malformations (bAVMs) are unusual vascular pathologies characterized by the abnormal aggregation of dilated arteries and veins in the brain parenchyma and for which the absence of a normal vascular structure and capillary bed leads to direct connections between arteries and veins. Although bAVMs have long been believed to be congenital anomalies that develop during the prenatal period, current studies show that inflammation is associated with AVM genesis, growth, and rupture. Interventional treatment options include microsurgery, stereotactic radiosurgery, and endovascular embolization, and management often comprises a multidisciplinary combination of these modalities. T…

The efficacy and safety of unfixed and fixed combinations of latanoprost and other antiglaucoma medications.

2002

Adjunctive therapy for the management of glaucoma is commonly used. Unfixed combinations of the prostaglandin analog latanoprost and other glaucoma medications have been demonstrated to effectively lower intraocular pressure (IOP). The range of reported additional reductions in IOP compared to a monotherapy baseline are as follows: latanoprost-timolol (13-37%), latanoprost-pilocarpine 2% (7-14%), latanoprost and carbonic anhydrase inhibitors (15-24.1%), and latanoprost and dipivefrin (15-28%). There is a fixed combination of latanoprost (0.005%) and timolol (0.5%) that has been investigated in Phase III trials in Europe and the United States. In these trials, it was noted that the efficacy …

Update on topical carbonic anhydrase inhibitors

2001

Topical carbonic anhydrase inhibitors are a novel addition to the armamentarium of medical glaucoma treatment; dorzolamide has been available since 1995 and brinzolamide since 1998. They lower intraocular pressure by inhibiting carbonic anhydrase, a key enzyme for aqueous humor formation. Intraocular pressure-lowering activity of the substances appears to be the same and is similar to that of most other agents, but it does not reach the activity of the unselective beta-blocker timolol or the prostaglandin latanoprost. On concomitant treatment, additivity is reached with all other topical agents. A possible improvement of blood flow may offer an additional benefit, but its significance for t…

Efficacy and safety of tafluprost 0.0015% and timolol maleate 0.5% fixed combination in patients with ocular hypertension or open-angle glaucoma.

2014

Lowering intraocular pressure (IOP) is at present the only therapeutic approach to the treatment of glaucoma proven to be successful. The choice of therapy must take into account efficacy, tolerability, safety, quality of life, adherence and cost. Monotherapy fails to achieve a satisfactory IOP reduction in 40 - 75% of glaucoma patients after2 years of therapy. So far, three prostaglandin/timolol maleate 0.5% fixed combinations (FCs) are available.This review provides a background on the tafluprost-timolol FC (TTFC, Santen Oy) and its individual compounds. It summarizes the data on efficacy and safety, including comparative data with prostaglandin/timolol FCs already available.Tafluprost is…

Addition of a fixed combination of brinzolamide 1%/timolol 0.5% to prostaglandin monotherapy in patients with glaucoma or ocular hypertension

2011

Katrin Lorenz1, Klaus Rosbach2, Andreas Matt3, Norbert Pfeiffer11University Medical Center, Johannes Gutenberg-Universität Mainz, Mainz, Germany; 2Private practice, Mainz, Germany; 3Private practice, Köln-Hohenhaus, GermanyBackground: This study was conducted to evaluate the safety and efficacy of adding a fixed combination of brinzolamide 1%/timolol 0.5% to prostaglandin analog (PGA) monotherapy in patients with primary open-angle glaucoma, pigment dispersion glaucoma, or ocular hypertension who require additional intraocular pressure (IOP) reduction.Methods: This was a prospective, multicenter (n = 5), open-label, single-arm, Phase IV clinical trial in which patients cur…

Modelli di consumo e nuovo paradigma della sostenibilità: i Gruppi di Acquisto Solidale in Sicilia

2010

European society, with its steadily increased welfare levels, is not only concerned about food (safety, prices), but also on other aspects such as biodiversity loss, landscape degradation, pollution of water, soil and atmosphere. To a large extent these concerns can be translated into a wider concept named sustainable development defined as a normative concept by Morgan and Sonnino (2008). Sustainability in the food chain means approaching a new emerging vision of a sustainable agro-food system introducing an institutional dimension to take into account. Among different attempts to conjugate such concepts, there is one that is taking place in many Regions of Italy. In the last years spontan…

The Italian competitiveness in the international market of the small fruits sector

2013

Recently, the markets globalization process has become increasingly intense leading to markets' hanges and a growth competition between companies operating on the international market. The agrifood sector among others has undergone several transformation characterized by the diffusion of modern New Technology, Information and Communication, the harmonization of regulations, and the reduction of technical barriers (Banterle and Olper, 2007). These last two changes were made due to the commercial bilateral signature or multilateral agreements. These changes have forced companies to rethink their strategies and organizational management. The Italian international agribusiness scenario plays an…