Search results for "Tissue"
showing 10 items of 4413 documents
Oral lichen planus and oral lichenoid lesions; a critical appraisal with emphasis on the diagnostic aspects
2009
Oral lichen planus (OLP) has a prevalence of approximately 1%. The etiopathogenesis is poorly understood. The annual malignant transformation is less than 0.5%. There are no effective means to either predict or to prevent such event. Oral lesions may occur that to some extent look like lichen planus but lacking the characteristic features of OLP, or that are indistinguishable from OLP clinically but having a distinct cause, e.g. amalgam restoration associated. Such lesions are referred to as oral lichenoid lesions (OLLs). The management of OLP and the various OLLs may be different. Therefore, accurate diagnosis should be aimed at.
Lichen Planus: A Muco-Cutaneous, Nails and Scalp Disorder – Cases Report
2019
Abstract Lichen planus is an autoimmune, itching disorder that involves T lymphocytes, which may interest the skin, mucous membranes and exoskeletons. The presence of lichen manifestations both at the skin, mucous membranes and at the level of the skin attachments (hair and nails) is rarely mentioned in the literature. Although lichen planus may have a self-limiting evolution, early treatment is important in shortening the evolution of the disease and in controlling the symptoms. The therapeutic effects of retinoids (immunomodulatory, anti-inflammatory, anti-proliferative effects) make them an appropriate choice in the treatment of lichen with (cutaneous-mucosal, nail and planopilaris lesio…
DEEP TISSUE MASSAGE AND FLEXIBILITY IN THE STRUCTURAL COMPONENTS OF THE SUPERFICIAL BACK LINE OF PROFESSIONAL VOLLEYBALL PLAYERS: A PILOT STUDY
2019
Background: Massage is a common treatment in physiotherapy, often used as a prophylaxis or during recovery following a musculoskeletal contusion. One form of therapeutic massage is deep tissue massage (DTM), which has become more popular in recent years as a way of performing targeted work with the myofascial system. Aim of the study: The aim of the study was to examine the effectiveness of deep tissue massage on superficial back line flexibility (hip flexion and knee extension range of motion - ROM). Material and methods: Elite volleyball players (n=15), age: 22.8 ± 4.41 years; mass: 82.67 ± 6.99 kg; height: 1.96 ± 0.08 m) were recruited for this study. Deep tissue massage of the myofascia…
Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018…
2018
Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean dia…
Absolute quantification of noncoding RNA by microscale thermophoresis
2019
Abstract Accurate quantification of the copy numbers of noncoding RNA has recently emerged as an urgent problem, with impact on fields such as RNA modification research, tissue differentiation, and others. Herein, we present a hybridization‐based approach that uses microscale thermophoresis (MST) as a very fast and highly precise readout to quantify, for example, single tRNA species with a turnaround time of about one hour. We developed MST to quantify the effect of tRNA toxins and of heat stress and RNA modification on single tRNA species. A comparative analysis also revealed significant differences to RNA‐Seq‐based quantification approaches, strongly suggesting a bias due to tRNA modifica…
Doppler ultrasound and giant cell arteritis
2010
Ana Marina Suelves1, Enrique España-Gregori1,2, Jose Tembl3, Stephanie Rohrweck1, Jose Maria Millán4, Manuel Díaz-Llopis1,4,51Service of Ophthalmology, La Fe University Hospital, Valencia, Spain; 2Department of Optics, University of Valencia, Valencia, Spain; 3Service of Neurology, La Fe University Hospital, Valencia, Spain; 4CIBERER, Ciber de Enfermedades Raras, Valencia, Spain; 5Faculty of Medicine, University of Valencia, Valencia, SpainObjective: To evaluate the utility of ultrasound in aiding the diagnosis of giant cell arteritis (GCA), in monitoring the response to corticotherapy, and in detecting early relapses.Methods: A pilot study, prospective, inc…
On the Choice of the Extracellular Vesicles for Therapeutic Purposes
2019
Extracellular vesicles (EVs) are lipid membrane vesicles released by all human cells and are widely recognized to be involved in many cellular processes, both in physiological and pathological conditions. They are mediators of cell-cell communication, at both paracrine and systemic levels, and therefore they are active players in cell differentiation, tissue homeostasis, and organ remodeling. Due to their ability to serve as a cargo for proteins, lipids, and nucleic acids, which often reflects the cellular source, they should be considered the future of the natural nanodelivery of bio-compounds. To date, natural nanovesicles, such as exosomes, have been shown to represent a source of diseas…
Considerations for the Analysis of Small Extracellular Vesicles in Physical Exercise
2020
Physical exercise induces acute physiological changes leading to enhanced tissue cross-talk and a liberation of extracellular vesicles (EVs) into the circulation. EVs are cell-derived membranous entities which carry bioactive material, such as proteins and RNA species, and are important mediators of cell-cell-communication. Different types of physical exercise interventions trigger the release of diverse EV subpopulations, which are hypothesized to be involved in physiological adaptation processes leading to health benefits and longevity. Large EVs (“microvesicles” and “microparticles”) are studied frequently in the context of physical exercise using straight forward flow cytometry approach…
Characterization of a novel three-dimensional outgrowth model of human bronchial mucosa
2011
Recently it has been hypothesized that a reactivation of the epithelial-mesenchymal trophic unit (EMTU) of the respiratory mucosa, caused by extensive epithelial damage, may be responsible for the pathogenesis of asthma. However, most research on this subject so far has been limited by the unavailability of in vitro models correctly mimicking the three-dimensional architecture of the properly differentiated human bronchial mucosa. For this reason, we have developed a novel 3D outgrowth model, obtained from bronchial biopsies and composed of both human bronchial epithelial cells (goblet and columnar cells) and fibroblasts with their basement membrane. Here we present the preliminary data obt…