Search results for "ToF"

Atrophic dermatofibrosarcoma protuberans with the fusion gene COL1A1-PDGFB

2008

Cartografia archeologica di base del sito di Elaiussa Sebaste da immagini satellitari ad alta risoluzione geometrica

2009

This paper sets out the research work carried out by the Unit of Palermo University within the FIRB 2003 National Programme, directed to the compilation of an archaeological base map of the Roman site at Elaiussa Sebaste. The employed methodology is based on the use of high resolution satellite imagery; particularly, a QuickBird image was used. A GPS survey was carried out in September 2008, aimed at determination of ground control points and spot heights used to georeference the image and to construct the DTM respectively. At last a digital orthophoto of the archaeological area was compiled from the acquired data.

Investigating different skin and gastrointestinal tract (GIT) pathologies ex vivo by autofluorescence spectroscopy and optical imaging

2017

The skin neoplasias are on a second place in the world statistics of cancer incidence, and gastrointestinal tract (GIT) tumours are also in the “top ten” list. For the most of cutaneous and gastrointestinal tumours could be obtained better prognoses for patients, if an earlier and precise diagnostics procedure is applied. One of the most promising approaches for development of improved diagnostic techniques, is based on optical detection, and analysis of the signatures of biological tissues for detecting the presence of pathological alterations in the investigated objects. It is important to develop and combine novel diagnostic techniques for an accurate early stage diagnosis to improve the…

Targeting the JAK/STAT Pathway: A Combined Ligand- and Target-Based Approach

2021

Janus kinases (JAKs) are a family of proinflammatory enzymes able to mediate the immune responses and the inflammatory cascade by modulating multiple cytokine expressions as well as various growth factors. In the present study, the inhibition of the JAK-signal transducer and activator of transcription (STAT) signaling pathway is explored as a potential strategy for treating autoimmune and inflammatory disorders. A computationally driven approach aimed at identifying novel JAK inhibitors based on molecular topology, docking, and molecular dynamics simulations was carried out. For the best candidates selected, the inhibitory activity against JAK2 was evaluated in vitro. Two hit compounds with…

Differential expression of SUC genes: A question of bases

1994

Non-coding nucleotide sequences located 5' upstream of the transcriptional start site play an essential role in gene expression as they contain binding sites for transcription and regulatory factors. The yeast SUC gene family is a useful model to study the influence that nucleotide exchanges within the promoter regions have on their expression, since (i) these genes, regulated by glucose repression, are differentially transcribed (invertase activity produced by distinct SUC genes may show variations of about 10-fold); and (ii) promoter sequences of SUC3, SUC4, SUC5 and SUC7 are more than 99% homologous, showing only six base exchanges among all of them. Comparison of these nucleotide exchan…

Identification of Older People at Risk of ADL Disability Using the Life-Space Assessment : A Longitudinal Cohort Study

2016

Abstract Objectives Life-space mobility, assessed with the Life-Space Assessment (LSA), reflects an individual's mobility in terms of the spatial area, frequency, and need for assistance. The aims were to study associations between life-space mobility and disability status in activities of daily living (ADL), and to define cutoff scores for baseline LSA and LSA change over time identifying individuals who developed ADL inability during 2 years of follow-up. Robustness of the cutoff scores was tested accounting for potential confounders. Design Longitudinal analyses of the “Life-space mobility in old age” cohort study. Setting Home-based interviews at baseline and phone interviews 2 years la…

Appunti sull’orientamento giovanile. A partire dalla pedagogia di Romano Guardini

2022

Alle già consistenti ricerche condotte in Italia sulla condizione giovanile, hanno dato eco una serie di più recenti studi durante il tempo pandemico, i quali hanno attestato l’acuirsi di alcune fragilità pre-esistenti e l’insorgere di nuovi bisogni educativi. A motivo dell’intreccio di molteplici variabili, personali, socio-economiche e storico-culturali, si è andata delineando l’immagine di una gioventù disorientata e difficile da orientare. Per far fronte a tale urgenza, ormai da diversi anni il dibattito pedagogico si dedica a riflettere su quali siano i principi più adeguati e i percorsi più efficaci per pensare e ri-pensare l’orientamento delle nuove generazioni, finalizzato al conseg…

Design, Synthesis and Biological Evaluation of 7-Chloro-9

2019

Glycogen synthase kinase-3β (GSK-3β) represents a relevant drug target for the treatment of neurodegenerative pathologies including Alzheimer’s disease. We herein report on the optimization of a novel class of GSK-3β inhibitors based on the tofacitinib-derived screen hit 3-((3R,4R)-3-((7-chloro-9H-pyrimido[4,5-b]indol-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile (1). We synthesized a series of 19 novel 7-chloro-9H-pyrimido[4,5-b]indole-based derivatives and studied their structure–activity relationships with focus on the cyanoacetyl piperidine moiety. We unveiled the crucial role of the nitrile group and its importance for the activity of this compound series. A successfu…

Differential expression of the invertase-encoding SUC genes in Saccharomyces cerevisiae

1992

Invertase (INV) is encoded in Saccharomyces cerevisiae by a family of genes, comprising SUC1-SUC5 and SUC7. Production of INV is highly variable, dependent on the strain and SUC gene present in the cell. The differences in INV production derive from the structure of the genes or are dependent on the genetic background of the strain. Centromeric plasmids (based on YCp50) carrying one of the SUC genes (except SUC7) were introduced into a strain (SEY2101) lacking SUC genes. The INV produced by the transformants was dependent on the individual SUC genes, and correlated with INV mRNA levels. Plasmids in which SUC2 had been placed under control of promoters from the other SUC genes, were used to …

Phenotype traits associated with different alleles at the RPS5 locus in Saccharomyces cerevisiae

1992

The RPS5 gene has been characterised through its ability to reduce invertase production by the SUC5 gene. In this paper we show that RPS5 acts by maintaining low levels of SUC5 mRNA. We also show that RPS5 acts on the SUC1 and SUC4 genes but not on SUC2 and SUC3, which are members of the SUC family. RPS5 also shows a pleiotropic effect on the amount of mitochondrial cytochromes.