Search results for "ToF"

Chromoendoscopy in Barrett's oesophagus: is cresyl violet the magic bullet?

2006

The endoscopic detection of Barrett’s epithelium remains challenging even for modern endoscopy. This is mainly due to the fact that Barrett’s epithelium is often patchy and can easily be overlooked by conventional endoscopy with random biopsies. Thus, chromoendoscopy and magnifying endoscopy were introduced to facilitate diagnosis of Barrett’s epithelium and Barrett’s associated neoplasias. Methylene blue-aided chromoendoscopy was firstly introduced by Canto et al. [1]. The authors could show that methylene blue selectively stains specialised columnar epithelium, which is pathognomonic for Barrett’s epithelium. In contrast, dysplastic areas revealed no or weaker staining due to changes in t…

The Man Behind the Eponym: Hans Biberstein and Follicular Hyperplasia Overlying Dermatofibroma

2009

Hans Biberstein first described the basaloid follicular hyperplasia overlying dermatofibromas in 1923 and published his extensive observations on the subject in 1931. Part of Josef Jadassohn's department in Breslau, he was forced to leave German by the National Socialist regime and spent the rest of his career in New York. After a hiatus of 30 years, the dermatopathologic literature once again began addressing his seminal finding but never gave him proper credit. We suggest Biberstein's sign as an appropriate term for basaloid follicular hyperplasia overlying a dermatofibroma and as a small tribute to a pioneer dermatopathologist.

Psychoanalytically-Oriented Inpatient Psychotherapy of Somatoform Disorders

2008

Somatoform disorders have been neglected in psychoanalytic publications. Unlike the descriptive approach of DSM-IV and ICD-10, sophisticated psychoanalytical models have been proposed for many years explaining the development of physical symptoms without definable medical cause. Based on a review of the psychoanalytic models of somatization and conversion, this article explores difficulties in the medical and psychotherapeutic treatments of somatoform disorders. The unique tradition of psychosomatic inpatient treatment in Germany is illustrated by the psychoanalytic treatment setting at the University of Mainz. A case report of a somatoform patient shows how childhood trauma is activated an…

Manualized psychodynamic-interactional group therapy for the treatment of somatoform pain disorders.

2010

Medically unexplained and clinically significant symptoms of pain are highly prevalent in the general population. More than one third of all patients in general practices and various departments of hospitals suffer from somatoform disorders with pain being the main complaint of 70% of these patients. This treatment manual is the first disorder-specific, psychodynamically oriented treatment for these patients. Based on psychodynamic-interactional group psychotherapy, it focuses on disorder-specific aspects as well as on psychic and interpersonal problems which have resulted from adverse childhood experiences and insecure attachment. In three treatment phases comprising an “information and mo…

Multi-spectral skin imaging by a consumer photo-camera

2010

The possibilities to perform multi-band spectral imaging by means of a consumer color camera without external filters have been studied. Images at up to 6 spectral bands may be extracted from a single color image after appropriate signal processing. The proposed technique was tested in pilot measurements of in-vivo skin hemoglobin maps and laser-excited autofluorescence images.

Autofluorescence imaging for recurrence detection in skin cancer postoperative scars

2020

This clinical study is a first attempt to use autofluorescence for recurrence diagnosis of skin cancer in postoperative scars. The proposed diagnostic parameter is based on a reduction in scar autofluorescence, evaluated in the green spectral channel. The validity of the method has been tested on 110 postoperative scars from 56 patients suspected of non-melanoma skin cancer, with eight patients (13 scars) available for the repeated examination. The recurrence diagnosis within a scar has been made after two subsequent autofluorescence check-ups, representing the temporal difference between the scar autofluorescence amplitudes as a vector. The recognition of recurrence has been discussed to r…

Double localization and multiple recurrences of dermatofibrosarcoma protuberans of the female breast: a rare clinical case.

2015

Not available

Opioid tolerance and dependence -- do they matter?

2004

The use of opioids has long been accepted as the standard of care in patients with cancer and acute pain. Opioids can further be used effectively in specific subgroups of patients with chronic nonmalignant pain states. While the development of tolerance and physical dependence are known effects of opioids in cancer and noncancer pain populations, these patients can not be regarded as addicted. However, long-term therapy with short-acting opioids predisposes to tolerance and addiction. Recent research has confirmed the important role of psychopathologic and psychosocial conditions as predictors of failed opioid effectiveness in a significant number of noncancer pain subgroups. The clinical p…

DOP41 Efficacy and safety of open-label treatment with tofacitinib 10 mg twice daily in patients with ulcerative colitis with clinical response, but …

2019

OP29 Tofacitinib in ulcerative colitis: Real-world evidence from Eneida Registry

2020

Abstract Background Our aim was to evaluate the effectiveness and safety of tofacitinib in ulcerative colitis (UC) in real life. Methods Patients from the prospectively maintained ENEIDA registry treated with tofacitinib due to active UC were included. Clinical activity and effectiveness were defined based on Partial Mayo Score (PMS). The short-term response was assessed at week 4, 8 and 16. The last-observation-carried-forward method was used in patients that stopped tofacitinib before the time-points for clinical assessment. Variables associated with short-term remission at week 8 were identified by logistic regression analysis. The cumulative retention rate and the cumulative incidence o…