Search results for "ToP"

The challenge of using the rheumatoid arthritis diagnostic criteria in clinical practice.

2015

The new 2010 ACR/EULAR (American College of Rheumatology/European League Against Rheumatism) criteria of Rheumatoid Arthritis recently published, have been released to classify and identify patients with early RA who could benefit from early therapy. They recommend anti-citrullinated protein antibody (ACPA) testing as an alternative criterion to Rheumatoid Factor (RF) and ACPA that were introduced together with the other classic criteria in a scoring system. We previously criticized these new criteria because of unavailable specificity and sensibility in the first paper, and the use of ACPA as dichotomous criterion (presence/absent) and alternatives to rheumatoid factor. Our previous work p…

Is time to joint replacement a valid outcome measure in clinical trials of drugs for osteoarthritis?

2003

The rate of radiographic joint space narrowing is commonly used today as a structural outcome measure in clinical trials evaluating potential disease-modifying drugs in patients with hip osteoarthritis, but this results in a continuous variable. Among the methods proposed to circumvent this problem, it has been suggested that the incidence of total hip arthoplasty (THA) provides a hard outcome measure. It is a dichotomized variable, easy to measure and sensitive to change, with acceptable intrinsic validity. However, because this measure is limited by the variability of factors underlying the decision to perform surgery and the length of waiting lists, it has been suggested that time to ful…

MINIMIZING INFLIXIMAB TOXICITY IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE

2008

Abstract Background Infliximab is a widely used biological agent for the treatment of inflammatory bowel disease, and has a favorable risk/benefit ratio. Aim It is useful to know that patients treated with infliximab are exposed to developing adverse events that could be reduced with a prudent and a rational clinical approach and by optimizing the treatment protocol. Methods PubMed (including Epub) was searched in October 2006 and again in March 2007. Results The high immunogenic potential of infliximab determines the antibodies that inhibit the effect of infliximab and the appearance of subsequent acute and delayed infusion reactions. Infliximab has an immunomodulatory effect, thus increas…

Distal Humerus Fractures

2014

Distal humerus fractures display seldom but severe injuries because of the complex distal humerus anatomy and often comminuted fracture types. They account for approximately 2–3 % of all fractures and for 17–30 % of fractures around the elbow. In younger patients, there is a predominance among males. The mechanism of accident is mostly a high-energy trauma in this population. In contrast, among elderly patients, distal humerus fractures concern mostly women with osteoporotic bone. Fractures are caused by a low-energy trauma such as a fall from standing height onto the outstretched or slightly flexed arm. These fractures are often severely comminuted. Because of the thin soft tissue envelope…

Postoperative Patient Education in Physiotherapy after Hip Arthroplasty : Patients' Perspective

2017

Objective The objective of the present study was to explore postoperative patient education in physiotherapy from total hip arthroplasty (THA) patients' perspectives, which has been a little‐studied area of research. The usefulness of rehabilitation protocols after THA has been debated over the years, and there are no clear guidelines for physiotherapy after THA Methods The data for the present qualitative study were collected from nine patients with THA by using individual interviews at the hospital after surgery. The interviews were audio‐recorded and analysed by using a phenomenographic method Results Four different categories of postoperative patient education in physiotherapy after hip…

Comparison of Postoperative Coronal Leg Alignment in Customized Individually Made and Conventional Total Knee Arthroplasty

2021

Neutral coronal leg alignment is known to be important for postoperative outcome in total knee arthroplasty (TKA). Customized individually made implants (CIM) instrumented with patient-specific cutting guides are an innovation aiming to increase the precision and reliability of implant positioning and reconstruction of leg alignment. We aimed to compare reconstruction of the hip–knee–ankle angle (HKA) of the novel CIM system iTotal™ CR G2 (ConforMIS Inc.) to a matched cohort of the off-the-shelf (OTS) knee replacement system Vanguard™ CR (Zimmer Biomet). Retrospective analysis of postoperative coronal full-leg weight-bearing radiographs of 562 TKA (283 CIM TKA, 279 OTS TKA) was conducted. V…

I beni archeologici ed etno-antropologici: Strumenti per il recupero dell’identità territoriale e di riscatto socio-economico

2007

Digi-sosiaalinen nuoriso ja musiikki : digitaalisen median vaikutukset nuorten musiikin kuunteluun

2016

Tutkimukseni tavoitteena on tarkastella, miten digitaalinen media vaikuttaa nuorten musiikin kuunteluun. Käsittelen aihetta tutkimalla kuuntelulähteiden ja kuunteluun saatavien idealähteiden suosiota. Lisäksi selvitän digitaalisen median ominaisuuksien käyttöä ja tutkin verkon sosiaalisten piirteiden liittymistä musiikin kuunteluun. Tutkimukseni on määrällinen Survey-tutkimus, jonka tavoitteena on kerätä tietoa suurehkosta määrästä edustavalla näytteellä. Keräsin tutkimusaineistoni kyselylomakkeella 154:lle seitsemäsluokkalaiselle yläkoululaiselle maaliskuussa 2015. Lomake oli pääosin strukturoitu, ja siihen vastattiin anonyymisti. Analysoin aineistoani tilastollisesti kuvaavana tarkastelem…

Musiikki työvälineenä kokonaisvaltaisessa opetuksessa

1999

Kokonaisarkkitehtuurin rooli hankehallinnassa : case sairaanhoitopiirit

2012

Kokonaisarkkitehtuurin rooli hankehallinnassa –tutkielmassa keskitytään tar-kastelemaan julkishallinnon hankehallinnon ja muutostenhallinnon tilaa sai-raanhoitopiireissä. Kirjallisuudessa kokonaisarkkitehtuuria suositellaan käytet-täväksi organisaatioiden kokonaisuuksien hallintaan. Kokonaisarkkitehtuurilla (KA) hallittaessa organisaatiossa toimintoja se muodostuu myös yhdeksi joh-tamistavaksi. Kokonaisarkkitehtuurilla pyritään siihen, että organisaation kaik-ki olennaiset hankkeet ohjaavat organisaation toimintatapoja ja järjestelmiä or-ganisaation haluamaan suuntaan. Suunta, johon pyritään, on kirjoitettuna or-ganisaatioiden strategiaan. Hankehallinto ja muutoshallinto ovat organisaatiois…