Search results for "ToP"
showing 10 items of 17685 documents
Structural Manipulations of Marine Natural Products Inspire a New Library of 3-Amino-1,2,4-Triazine PDK Inhibitors Endowed with Antitumor Activity in…
2023
Pancreatic ductal adenocarcinoma (PDAC) is one of the main aggressive types of cancer, characterized by late prognosis and drug resistance. Among the main factors sustaining PDAC progression, the alteration of cell metabolism has emerged to have a key role in PDAC cell proliferation, invasion, and resistance to standard chemotherapeutic agents. Taking into account all these factors and the urgency in evaluating novel options to treat PDAC, in the present work we reported the synthesis of a new series of indolyl-7-azaindolyl triazine compounds inspired by marine bis-indolyl alkaloids. We first assessed the ability of the new triazine compounds to inhibit the enzymatic activity of pyruvate de…
Interno, Esterno, Frontiera. Note sulla Topologia dei Domini Nozionali
2014
This article examines a fundamental metalinguistic construction of the theory of enunciative operations: the Notional Domain. In particular, we try to explain some particular topological concepts on which this construction is based and we try to show the key role they play in the description of some basic linguistic operations: "fragmentation" and "construction of existence"
Mass measurements of As, Se, and Br nuclei, and their implication on the proton-neutron interaction strength toward the N=Z line
2021
Mass measurements of the $^{69}$As, $^{70,71}$Se and $^{71}$Br isotopes, produced via fragmentation of a $^{124}$Xe primary beam at the FRS at GSI, have been performed with the multiple-reflection time-of-flight mass spectrometer (MR-TOF-MS) of the FRS Ion Catcher with an unprecedented mass resolving power of almost 1,000,000. For the $^{69}$As isotope, this is the first direct mass measurement. A mass uncertainty of 22 keV was achieved with only 10 events. For the $^{70}$Se isotope, a mass uncertainty of 2.6 keV was obtained, corresponding to a relative accuracy of $\delta$m/m = 4.0$\times 10^{-8}$, with less than 500 events. The masses of the $^{71}$Se and $^{71}$Br isotopes were measured…
Recent experiments at the JYFLTRAP Penning trap
2020
AbstractThe JYFLTRAP double Penning trap mass spectrometer at the Ion Guide Isotope Separator On-Line (IGISOL) facility offers excellent possibilities for high-precision mass measurements of radioactive ions. Around 400 atomic masses, including around 50 isomeric states, have been measured since JYFLTRAP became operational. JYFLTRAP has also been used as a high-resolution mass separator for decay spectroscopy experiments as well as an ion counter for fission yield studies. In this contribution, an overview of recent activities at the JYFLTRAP Penning trap is given, with a focus on nuclei discussed in the PLATAN2019 meeting.
Penning-trap mass measurements on 92, 94-98, 100Mo with JYFLTRAP
2012
Penning-trap measurements on stable 92, 94-98, 100Mo isotopes have been performed with relative accuracy of \ensuremath1⋅10−8\ensuremath1⋅10−8 with the JYFLTRAP Penning-trap mass spectrometer by using 85Rb as a reference. The Mo isotopes have been found to be about 3keV more bound than given in the Atomic Mass Evaluation 2003 (AME03). The results confirm that the discrepancy between the ISOLTRAP and JYFLTRAP data for 101-105Cd isotopes was due to an erroneous value in the AME03 for 96Mo used as a reference at JYFLTRAP. The measured frequency ratios of Mo isotopes have been used to update mass-excess values of 30 neutron-deficient nuclides measured at JYFLTRAP. peerReviewed
Cytoplasmic parvovirus capsids recruit importin beta for nuclear delivery
2020
Parvoviruses are an important platform for gene and cancer therapy. Their cell entry and the following steps including nuclear import are inefficient limiting their use in therapeutic applications. Two models exist on parvoviral nuclear entry: classical import of the viral capsid using nuclear transport receptors of the importin (karyopherin) family, or direct attachment of the capsid to the nuclear pore complex leading to local disintegration of the nuclear envelope. Here, by laser scanning confocal microscopy and in situ proximity ligation analysis combined with co-immunoprecipitation we showed that infection requires importin β-mediated access into the nuclear pore complex and nucleopori…
Estudio del quark top en modelos de nueva física utilizando las infraestructuras Tier2 y Tier3 de Valencia
2011
25 páginas. Tesis de Máster de Física Avanzada del Departamento de Física Atómica, Molecular y Nuclear de la Universitat de Valencia. Fecha de lectura: 16 septiembre 2011.
Numerical construction of the density-potential mapping
2018
We demonstrate how a recently developed method Nielsen et al. [Nielsen et al., EPL 101, 33001 (2013)] allows for a comprehensive investigation of time-dependent density functionals in general, and of the exact time-dependent exchange-correlation potential in particular, by presenting the first exact results for two- and three-dimensional multi-electron systems. This method is an explicit realization of the Runge–Gross correspondence, which maps time-dependent densities to their respective potentials, and allows for the exact construction of desired density functionals. We present in detail the numerical requirements that makes this method efficient, stable and precise even for large and rap…
Nuoret aikuiset maksullisten suoratoistopalvelujen kuluttajina
2017
Suoratoistopalvelut ovat nykyään pohjoismaissa erittäin suosittuja ja yli 80 prosenttia suomalaisista on katsonut viimeisen puolen vuoden aikana suoratoistosisältöä. Tosin aikaisempien tutkimusten mukaan suoratoistosisällöistä maksaneiden osuus on ollut Suomessa pohjoismaiden pienin. Tämän tutkielman tavoite oli selvittää, kuinka paljon nuoret suomalaiset aikuiset ovat valmiita maksamaan suoratoistopalvelujen käytöstä, kuinka halukkaita he ovat käyttämään maksullisia suoratoistopalveluja ja mitkä tekijät vaikuttavat maksullisten suoratoistopalvelujen omaksumiseen. Tutkimus toteutettiin kirjallisuuskatsauksena ja strukturoituna kyselytutkimuksena. Tutkimuksen aineisto kerättiin touko-kesäkuu…
Peruskoulusta elämänkouluun : ammatillisesta koulutuksesta syrjäytymisvaarassa olevien nuorten aikuisten tarinoita peruskoulusuhteesta ja elämänkulus…
2010
Lasten ja nuorten vointi koulussa on kehittynyt vastakkaisiin suuntiin. Enemmistö voi hyvin, mutta yhä useampi kärsii esimerkiksi jännittämisestä, keskittymis- ja motivaatiovaikeuksista, kiusaamisesta, masennuksesta tai ulkopuolisuuden tunteesta. He ovat tuen tarpeessa, mutta koulun ennaltaehkäisevä toiminta on puutteellista. Moni nuori on vaarassa pudota koulun kyydistä ja myöhemmin työelämästä. Tutkimus valaisee oppilaiden jännitteisessä koulusuhteessa ja peruskoulun jälkeisessä elämänkulussa muodostuvia ongelmakimppuja ja kielteisiä kehiä. Julkaisu johdattaa paljastavin esimerkein pohtimaan koulun toimintamekanismeihin kätkeytyviä heikkouksia ja riskejä. Ne voivat pahimmillaan johtaa elä…