Search results for "Toes"
showing 10 items of 134 documents
Dietary exposure in utero and during lactation to a mixture of genistein and an anti-androgen fungicide in a rat mammary carcinogenesis model
2015
Endocrine disruptors may play substantial roles in the high incidence of breast cancer. We previously described how early exposure to the mixture of phytoestrogen genistein (G) and the anti-androgen vinclozolin (V) affects peripubertal mammary development. This study evaluates the carcinogenic potential of exposure to V alone or associated with G from conception until weaning in Wistar rats. Dams were exposed to V, G or GV during pregnancy/lactation. At PND50 offspring were treated with DMBA[7,12-dimethylbenz(a)anthracene]. V or GV maternal exposure decreased number of DMBA-induced mammary tumors in the offspring, without significant modifications in tumor incidence, multiplicity and latenc…
Isoflavonoid-based bone-sparing treatments exert a low activity on reproductive organs and on hepatic metabolism of estradiol in ovariectomized rats
2007
International audience; The use of soy isoflavones is a potential alternative to hormone replacement therapy in post-menopausal bone-loss prevention. Nevertheless, phytoestrogens can target other organs and may disrupt cell proliferation, or could modify endogenous steroid hormone metabolism. These mechanisms could be linked to an increased risk of developing cancer. We therefore studied the possible side effects of such treatments in an experimental model of menopause. Forty adult female Wistar rats were ovariectomized and fed with a genistein-, daidzein- or equol-supplemented diet at bone-sparing levels (10 mg/kg BW/day) for 3 months. The estrogenic effects were assessed by histological a…
Autoestima, percepción de estrés y ánimo depresivo en grupos de riesgo.
2001
Los grupos de riesgo se caracterizan por una mayor vulnerabilidad a desarrollar problemas psicológicos y sociales y, por tanto, suelen ser los destinatarios prioritarios de muchas de las intervenciones realizadas por los trabajadores sociales. En este sentido, en esta investigación se analizan tres variables psicológicas que pueden estar relacionadas con la mayor vulnerabilidad de los diversos grupos de riesgo- En concreto, se comparan las variables de autoestima, percepción de estrés y ánimo depresivo en personas que manifiestan un problema de salud física como es la hipertensión (n=30) y en personas con un problema de tipo psicosocial como es el consumo abusivo de alcohol (n=47) en relaci…
Ansiedad de ejecución, atención plena, autocompasión, rendimiento y satisfacción académica en estudiantes de música de la Universidad Autónoma de San…
2015
La ansiedad de ejecución musical suele ser un problema significativo en los estudiantes de música universitarios. Esta ansiedad generada en el músico, ya sea profesional o estudiante, se ha explicado y tratado desde diversas perspectivas teóricas (farmacológica, conductual, cognitivo-conductual). Sin embargo, en este momento, ya se empieza a consolidar la perspectiva contemplativa que surge de las denominadas, en psicología clínica, terapias de tercera generación. En este estudio, nos hemos centrado en una de ellas, el mindfulness o atención plena –atención o conciencia deliberada en el momento presente y sin juzgar- y un constructo básico en ella: la autocompasión –relación con nosotros mi…
Double nail of the second toe: A case report with sonographic and radiological correlation
2021
Double toenail is a rare abnormality that usually affects the fifth toe. It is considered as an inherited condition that may represent an incomplete form of polydactyly. Underlying bone abnormalities should be ruled out. We present a case of a double toenail of the second toe, a location that has not previously been described, with underlying bone involvement noted on ultrasound and plain films.
Efecto de un programa de intervención sobre el estrés percibido, autoestima y rendimiento en jóvenes pilotos de motociclismo de elite
2013
En la especialidad deportiva de motociclismo la literatura científica se ha centrado en aspectos tecnológicos, de seguridad, incluso patrones de lesiones, existiendo poca información sobre variables psicológicas de los deportistas. El objetivo de nuestro estudio fue evaluar si el efecto de una intervención en habilidades técnicas y condición física sobre la percepción de estrés, autoestima, la autovaloración, la valoración de otros, y finalmente la ejecución. La muestra estuvo compuesto por 27 pilotos jóvenes de élite, participantes del Red Bull Moto GP Rookies Cup, de los cuales 16 sujetos realizaron un programa de intervención (Grupo Experimental, GE), mientras que el resto fue el Grupo C…
Validesa transcultural del model quatripartit de socialització familiar: estudi comparatiu entre la cultura peruana i espanyola
2014
Aquesta investigació pretén comparar els estils de socialització, amb els quals, els pares eduquen i socialitzen als seus fills i la influència d'aquests en l'ajustament psicosocial a dues cultures, l'espanyola ja estudiada per molts d'autors, i la peruana la qual fins el dia d'avui és una mostra inèdita en aquests tipus d'estudis. Partim, doncs, de tres qüestions fonamentals, que es plantegen als estudis sobre els processos i estils de socialització parental en l'adolescència: com socialitzen els pares als seus fills en l'etapa de l'adolescència?, existeix un estil òptim de socialització dels pares per millorar l'ajustament psicosocial dels seus fills?, estem determinats culturalment alhor…
Anatomical Network Comparison of Human Upper and Lower, Newborn and Adult, and Normal and Abnormal Limbs, with Notes on Development, Pathology and Li…
2015
How do the various anatomical parts (modules) of the animal body evolve into very different integrated forms (integration) yet still function properly without decreasing the individual’s survival? This long-standing question remains unanswered for multiple reasons, including lack of consensus about conceptual definitions and approaches, as well as a reasonable bias toward the study of hard tissues over soft tissues. A major difficulty concerns the non-trivial technical hurdles of addressing this problem, specifically the lack of quantitative tools to quantify and compare variation across multiple disparate anatomical parts and tissue types. In this paper we apply for the first time a powerf…
ERa dimerization: a key factor for the weak estrogenic activity of an ERa modulator unable to compete with estradiol in binding assays
2016
PMID: 27400858; International audience; AbstractEstrothiazine (ESTZ) is a weak estrogen sharing structural similarities with coumestrol. ESTZ failed to compete with [3H]17β-estradiol ([3H]17β-E2) for binding to the estrogen receptor α (ERα), questioning its ability to interact with the receptor. However, detection by atomic force spectroscopy (AFS) of an ESTZ-induced ERα dimerization has eliminated any remaining doubts. The effect of the compound on the proliferation of ERα-positive and negative breast cancer cells confirmed the requirement of the receptor. The efficiency of ESTZ in MCF-7 cells was weak without any potency to modify the proliferation profile of estradiol and coumestrol. Gro…
Dietary phytoestrogens improve stroke outcome after transient focal cerebral ischemia in rats.
2006
As phytoestrogens are postulated as being neuroprotectants, we assessed the hypothesis that dietary isoflavone-type phytoestrogens are neuroprotective against ischemic stroke. Transient focal cerebral ischemia (90 min) was induced by middle cerebral artery occlusion (MCAO) following the intraluminal thread technique, both in rats fed with soy-based diet and in rats fed with isoflavone-free diet. Cerebro-cortical laser-Doppler flow (cortical perfusion, CP), arterial blood pressure, core temperature, PaO2, PaCO2, pH and glycemia were measured before, during and after MCAO. Neurological examination and infarct volume measurements were carried out 3 days after the ischemic insult. Dietary isofl…